(Q33916100)

30 July 2017

1 reference

title

Molecular mechanisms of action of antisense drugs (English)

1 reference

30 July 2017

S T Crooke

1

1 reference

PubMed ID

10806995

30 July 2017

language of work or name

English

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publication date

1 December 1999

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Biochimica et Biophysica Acta

30 July 2017

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30 July 2017

1489

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30 July 2017

31-44

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30 July 2017

1

1 reference

A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease.

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

RNA 3' end formation in the control of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Polyadenylation of mRNA precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Splicing of messenger RNA precursors

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

1 reference

7 January 2021

Predicting DNA duplex stability from the base sequence

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Improved free-energy parameters for predictions of RNA duplex stability

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Acid multimers of oligodeoxycytidine strands: stoichiometry, base-pair characterization, and proton exchange properties

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

A tetrameric DNA structure with protonated cytosine.cytosine base pairs

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Tumour-specific inhibition of lymphoma growth by an antisense oligodeoxynucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Inhibition of replication and expression of human T-cell lymphotropic virus type III in cultured cells by exogenous synthetic oligonucleotides complementary to viral RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Restoration of correct splicing in thalassemic pre-mRNA by antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Prothymosin alpha antisense oligomers inhibit myeloma cell division

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Specific inhibition of cell-surface T-cell receptor expression by antisense oligodeoxynucleotides and its effect on the production of an antigen-specific regulatory T-cell factor

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Molecular mechanisms of antisense drugs: RNase H.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Pseudo--half-knot formation with RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Complementary oligodeoxynucleotide mediated inhibition of tobacco mosaic virus RNA translation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Site specific enzymatic cleavage of RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Highly efficient chemical synthesis of 2'-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Alpha-DNA.IX: Parallel annealing of alpha-anomeric oligodeoxyribonucleotides to natural mRNA is required for interference in RNase H mediated hydrolysis and reverse transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Inhibition of DNA binding proteins by oligonucleotide-directed triple helix formation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Number and distribution of methylphosphonate linkages in oligodeoxynucleotides affect exo- and endonuclease sensitivity and ability to form RNase H substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

The use of single-stranded DNA and RNase H to promote quantitative 'hybrid arrest of translation' of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Molecular cloning and expression of cDNA for human RNase H.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Reactive oligonucleotide derivatives and sequence-specific modification of nucleic acids

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific crosslinking agents for nucleic acids. Use of 6-bromo-5,5-dimethoxyhexanohydrazide for crosslinking cytidine to guanosine and crosslinking RNA to complementary sequences of DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Hybridization triggered cross-linking of deoxyoligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Site-specific oligonucleotide binding represses transcription of the human c-myc gene in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-[alpha]-thymidylate covalently linked to an azidoproflavine derivative

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Complementary addressed modification of double-stranded DNA within a ternary complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-targeted photosensitized reactions in nucleic acids by oligo-alpha-deoxynucleotides and oligo-beta-deoxynucleotides covalently linked to proflavin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-targeted photochemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Identification of the molecular defect in a family with spondyloepiphyseal dysplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Double helices with parallel strands are formed by nuclease-resistant oligo-[alpha]-deoxynucleotides and oligo-[alpha]-deoxynucleotides covalently linked to an intercalating agent with complementary oligo-[beta]-deoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Control of gene expression by oligonucleotides covalently linked to intercalating agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Photochemical cross-linking of psoralen-derivatized oligonucleoside methylphosphonates to rabbit globin messenger RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Short modified antisense oligonucleotides directed against Ha-ras point mutation induce selective cleavage of the mRNA and inhibit T24 cells proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific cleavage of double helical DNA by triple helix formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Nonenzymatic sequence-specific cleavage of single-stranded DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Periodic cleavage of poly(dA) by oligothymidylates covalently linked to the 1,10-phenanthroline-copper complex

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-specific recognition and cleavage of duplex DNA via triple-helix formation by oligonucleotides covalently linked to a phenanthroline-copper chelate

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Sequence-targeted cleavage of nucleic acids by oligo-alpha-thymidylate-phenanthroline conjugates: parallel and antiparallel double helices are formed with DNA and RNA, respectively.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

The chemistry of self-splicing RNA and RNA enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Simple RNA enzymes with new and highly specific endoribonuclease activities

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Minimal sequence requirements for ribozyme activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and Mg2+ binding

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

External Guide Sequences for an RNA Enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

Targeted cleavage of mRNA by human RNase P

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

DNA cleavage catalysed by the ribozyme from Tetrahymena

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4781%2899%2900148-7

7 January 2021

10.1016/S0167-4781(99)00148-7

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10806995