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Unwinding the loop of Bcl-2 phosphorylation
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scholarly article
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
review article
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Europe PubMed Central
title
Unwinding the loop of Bcl-2 phosphorylation
(English)
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
main subject
phosphorylation
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author
Mikhail Blagosklonny
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1
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Blagosklonny MV
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
publication date
1 June 2001
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
published in
Leukemia
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
volume
15
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
page(s)
869-874
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
issue
6
1 reference
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Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
exact match
https://scigraph.springernature.com/pub.10.1038/sj.leu.2402134
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cites work
A day in the life of the Bcl-2 protein: does the turnover rate of Bcl-2 serve as a biological clock for cellular lifespan regulation?
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Double identity for proteins of the Bcl-2 family
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BCL-2 family: regulators of cell death
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Bcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?
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7 January 2021
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Inactivation of Bcl-2 by phosphorylation
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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Bcl-2 phosphorylation required for anti-apoptosis function
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7 January 2021
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Microtubules and actin filaments: dynamic targets for cancer chemotherapy
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein
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7 January 2021
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Mitotic phosphorylation of Bcl-2 during normal cell cycle progression and Taxol-induced growth arrest
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7 January 2021
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Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.
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7 January 2021
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Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Apoptosis: cell death defined by caspase activation
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Caspases and apoptosis – biology and terminology
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Cell death beyond apoptosis
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7 January 2021
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More than one way to go.
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7 January 2021
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Mitochondria and apoptosis
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7 January 2021
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BCL-2 family members and the mitochondria in apoptosis
1 reference
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7 January 2021
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Temporal relationship of CDK1 activation and mitotic arrest to cytosolic accumulation of cytochrome C and caspase-3 activity during Taxol-induced apoptosis of human AML HL-60 cells
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Interleukin-3 induces the phosphorylation of a distinct fraction of bcl-2.
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Loss of the bcl-2 phosphorylation loop domain increases resistance of human leukemia cells (U937) to paclitaxel-mediated mitochondrial dysfunction and apoptosis
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
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The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2.
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Checkpoints controlling mitosis
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7 January 2021
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A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
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7 January 2021
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Okadaic acid induces interphase to mitotic-like microtubule dynamic instability by inactivating rescue
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation
1 reference
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Molecular effects of paclitaxel: myths and reality (a critical review).
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7 January 2021
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Repression of TFIIH transcriptional activity and TFIIH-associated cdk7 kinase activity at mitosis
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Ability of the c- mos Product to Associate with and Phosphorylate Tubulin
1 reference
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7 January 2021
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Association of mitogen-activated protein kinase with the microtubule cytoskeleton
1 reference
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7 January 2021
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Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Characterization of Raf-1 activation in mitosis
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Mitotic Raf-1 is stimulated independently of Ras and is active in the cytoplasm
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade
1 reference
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7 January 2021
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Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Raf-1 protein kinase is important for progesterone-induced Xenopus oocyte maturation and acts downstream of mos
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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c-Jun N-terminal kinase activation in Xenopus laevis eggs and embryos. A possible non-genomic role for the JNK signaling pathway
1 reference
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7 January 2021
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Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Bryostatin 1 enhances paclitaxel-induced mitochondrial dysfunction and apoptosis in human leukemia cells (U937) ectopically expressing Bcl-xL
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
MEK inhibition enhances paclitaxel-induced tumor apoptosis
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
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Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
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Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Medroxyprogesterone acetate inhibits human pancreatic carcinoma cell growth by inducing apoptosis in association with Bcl-2 phosphorylation
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
A node between proliferation, apoptosis, and growth arrest
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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inferred from DOI database lookup
Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Apoptotic pathways: paper wraps stone blunts scissors
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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The most unkindest cut of all: on the multiple roles of mammalian caspases
1 reference
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7 January 2021
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Genetic analysis of chemoresistance in primary murine lymphomas.
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
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Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
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7 January 2021
based on heuristic
inferred from DOI database lookup
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402134
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.LEU.2402134
1 reference
stated in
Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
Dimensions Publication ID
1024572485
0 references
PubMed ID
11417471
1 reference
stated in
Europe PubMed Central
PubMed ID
11417471
retrieved
30 July 2017
ResearchGate publication ID
11923751
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