(Q33962694)

30 July 2017

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title

Human papillomavirus immortalization and transformation functions (English)

1 reference

30 July 2017

Karl Münger

1

1 reference

PubMed ID

12445661

30 July 2017

Peter M Howley

series ordinal

2

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30 July 2017

1 November 2002

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30 July 2017

1 reference

30 July 2017

89

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30 July 2017

213-228

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30 July 2017

2

1 reference

Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Plurality of genital human papillomaviruses: characterization of two new types with distinct biological properties

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The E5 oncoprotein of bovine papillomavirus is oriented asymmetrically in Golgi and plasma membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Dimerization of the human papillomavirus E7 oncoprotein in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Oligomerization properties of the viral oncoproteins adenovirus E1A and human papillomavirus E7 and their complexes with the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Nucleotide sequence and comparative analysis of the human papillomavirus type 18 genome. Phylogeny of papillomaviruses and repeated structure of the E6 and E7 gene products

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Enhancement of EGF- and PMA-mediated MAP kinase activation in cells expressing the human papillomavirus type 16 E5 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

A transcriptionally active DNA-binding site for human p53 protein complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Induction of pRb degradation by the human papillomavirus type 16 E7 protein is essential to efficiently overcome p16INK4a-imposed G1 cell cycle Arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Genetic analysis of the 3' early region transformation and replication functions of bovine papillomavirus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

1 reference

7 January 2021

44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Immortalization of primary rat cells by human papillomavirus type 16 subgenomic DNA fragments controlled by the SV40 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Characterization of primary human keratinocytes transformed by human papillomavirus type 18.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Telomerase activation by the E6 gene product of human papillomavirus type 16.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 DNA cooperates with activated ras in transforming primary cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Biological activities and molecular targets of the human papillomavirus E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Alternatively spliced HPV-18 E6* protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Bovine papillomavirus type 1 3' early region transformation and plasmid maintenance functions

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Binding of human papillomavirus 16 E5 to the 16 kDa subunit c (proteolipid) of the vacuolar H+-ATPase can be dissociated from the E5-mediated epidermal growth factor receptor overactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Expression of human papillomavirus type 16 E7 gene induces DNA synthesis of rat 3Y1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

E5 open reading frame of bovine papillomavirus type 1 encodes a transforming gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The E5 transforming gene of bovine papillomavirus encodes a small, hydrophobic polypeptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Comparison of the in vitro transforming activities of human papillomavirus types.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 31 oncoproteins E6 and E7 are required for the maintenance of episomes during the viral life cycle in normal human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Transformation of rat 3Y1 cells by human papillomavirus type-18 DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Immortalization of distinct human mammary epithelial cell types by human papilloma virus 16 E6 or E7.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Cellular targets for transformation by the adenovirus E1A proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

p21 is a universal inhibitor of cyclin kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Functional dissociation of transforming genes of human papillomavirus type 16.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1 reference

https://api.crossref.org/works/10.1016%2FS0168-1702%2802%2900190-9

7 January 2021

10.1016/S0168-1702(02)00190-9

Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

12445661