(Q33964294)

30 July 2017

1 reference

title

Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors (English)

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30 July 2017

Communi D

1

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30 July 2017

Janssens R

2

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30 July 2017

Suarez-Huerta N

3

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30 July 2017

Robaye B

4

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30 July 2017

Boeynaems JM

5

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30 July 2017

1 June 2000

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30 July 2017

10

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inferred from page(s)

published in

Cellular Signalling

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30 July 2017

12

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30 July 2017

351-360

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30 July 2017

6

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Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

30 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Shear stress-induced [Ca2+]i transients and oscillations in mouse fibroblasts are mediated by endogenously released ATP.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes--a possible sensory mechanism?

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

A release mechanism for stored ATP in ocular ciliary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cystic fibrosis transmembrane regulator-independent release of ATP. Its implications for the regulation of P2Y2 receptors in airway epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Increased shear stress leads to differential release of endothelin and ATP from isolated endothelial cells from 4- and 12-month-old male rabbit aorta

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Continuous detection of extracellular ATP on living cells by using atomic force microscopy

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The multidrug resistance (mdr1) gene product functions as an ATP channel

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Failure of the cystic fibrosis transmembrane conductance regulator to conduct ATP.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Purified cystic fibrosis transmembrane conductance regulator (CFTR) does not function as an ATP channel

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Connexins regulate calcium signaling by controlling ATP release

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Quantitation of extracellular UTP using a sensitive enzymatic assay

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Identification of an ecto-nucleoside diphosphokinase and its contribution to interconversion of P2 receptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

A new class of ligand-gated ion channel defined by P2x receptor for extracellular ATP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Families of ion channels with two hydrophobic segments

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloned ligand-gated channels activated by extracellular ATP (P2X receptors).

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Functional and molecular diversity of purinergic ion channel receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Evidence for cAMP-dependent platelet ectoprotein kinase activity that phosphorylates platelet glycoprotein IV (CD36)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Analysis of CD36 binding domains: ligand specificity controlled by dephosphorylation of an ectodomain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and functional expression of a brain G-protein-coupled ATP receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Expression cloning of an ATP receptor from mouse neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning of rat and mouse P2Y purinoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and characterisation of a bovine P2Y receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and chromosomal localization of the human P2Y1 purinoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and tissue distribution of the human P2Y1 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and functional expression of a human uridine nucleotide receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular cloning and characterization of rat P2Y4 nucleotide receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular cloning and expression of an avian G protein-coupled P2Y receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular cloning and functional analysis of a novel P2 nucleotide receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning, functional expression and tissue distribution of the human P2Y6 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Human P2Y2 receptor polymorphism: identification and pharmacological characterization of two allelic variants

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Heterogeneity of ATP receptors in aortic endothelial cells. Involvement of P2y and P2u receptors in inositol phosphate response

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The P2U purinoceptor obligatorily engages the heterotrimeric G protein G16 to mobilize intracellular Ca2+ in human erythroleukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Pharmacological characterization of the human P2Y4 receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Multiple signal transduction pathways lead to extracellular ATP-stimulated mitogenesis in mammalian cells: II. A pathway involving arachidonic acid release, prostaglandin synthesis, and cyclic AMP accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2 purinoceptor-mediated cyclic AMP accumulation in bovine vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Evidence that ATP, ADP and AMP are not ligands of the striatal adenosine A2A receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

ATP activates cAMP production via multiple purinergic receptors in MDCK-D1 epithelial cells. Blockade of an autocrine/paracrine pathway to define receptor preference of an agonist.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Specific activation of adenylyl cyclase V by a purinergic agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2-purigenic receptors regulate phospholipase C and adenylate cyclase activities in immortalized Schwann cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Potent agonist action of 2-thioether derivatives of adenine nucleotides at adenylyl cyclase-linked P2Y-purinoceptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Fidelity in functional coupling of the rat P2Y1 receptor to phospholipase C.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Cloning and functional expression of the human histamine H3 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2Y receptor subtypes differentially couple to inwardly-rectifying potassium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Inhibition by heterologously-expressed P2Y2 nucleotide receptors of N-type calcium currents in rat sympathetic neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Selective inhibition of M-type potassium channels in rat sympathetic neurons by uridine nucleotide preferring receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Purine and pyrimidine nucleotides inhibit a noninactivating K+ current and depolarize adrenal cortical cells through a G protein-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

A guanine nucleotide-independent inwardly rectifying cation permeability is associated with P2Y1 receptor expression in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Phosphorylation and activation of p42 and p44 mitogen-activated protein kinase are required for the P2 purinoceptor stimulation of endothelial prostacyclin production

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Stimulation by the nucleotides, ATP and UTP of mitogen-activated protein kinase in EAhy 926 endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Purinergic stimulation of rat cardiomyocytes induces tyrosine phosphorylation and membrane association of phospholipase C gamma: a major mechanism for InsP3 generation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The human platelet ADP receptor activates Gi2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Identification of a P2X1 purinoceptor expressed on human platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Ticlopidine and clopidogrel

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Role of P2Y1 purinoceptor in ADP-induced platelet activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

P2Y1-receptors in human platelets which are pharmacologically distinct from P2Y(ADP)-receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Functionally thrombasthenic state in normal platelets following the administration of ticlopidine

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

cAMP is not an important messenger for ADP-induced platelet aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Altered fluid transport across airway epithelium in cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP, ADP, and adenosine

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Acute safety and effects on mucociliary clearance of aerosolized uridine 5'-triphosphate +/- amiloride in normal human adults

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Effect of uridine 5'-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Membrane-restricted regulation of Ca2+ release and influx in polarized epithelia

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Expression of P2Y receptors in cell lines derived from the human lung

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Extracellular ATP triggers cyclic AMP-dependent differentiation of HL-60 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Pharmacological profile of a novel cyclic AMP-linked P2 receptor on undifferentiated HL-60 leukemia cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

Extracellular ATP-stimulated increase of cytosolic cAMP in HL-60 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2800%2900083-8

7 January 2021

10.1016/S0898-6568(00)00083-8

Identifiers

DOI

1 reference

30 July 2017

1 reference