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Prodrug activation enzymes in cancer gene therapy
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Prodrug activation enzymes in cancer gene therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
main subject
gene therapy
0 references
cancer gene therapy
1 reference
based on heuristic
inferred from title
author
Xandra O. Breakefield
series ordinal
3
object named as
Breakefield XO
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
author name string
Aghi M
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
Hochberg F
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
publication date
1 May 2000
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
published in
Journal of Gene Medicine
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
volume
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
page(s)
148-164
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
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2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.
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In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
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Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment
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The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions
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Involvement of Fas (CD95/APO-1) and Fas ligand in apoptosis induced by ganciclovir treatment of tumor cells transduced with herpes simplex virus thymidine kinase
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The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
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Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors
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A "distant" bystander effect of suicide gene therapy: regression of nontransduced tumors together with a distant transduced tumor
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Regression of established macroscopic liver metastases after in situ transduction of a suicide gene
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Liposomal encapsulation of ganciclovir enhances the efficacy of herpes simplex virus type 1 thymidine kinase suicide gene therapy against hepatic tumors in rats.
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Superior cytostatic activity of the ganciclovir elaidic acid ester due to the prolonged intracellular retention of ganciclovir anabolites in herpes simplex virus type 1 thymidine kinase gene-transfected tumor cells
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Bystander effect of purine nucleoside analogues in HSV-1 tk suicide gene therapy is superior to that of pyrimidine nucleoside analogues
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The equine herpes virus 4 thymidine kinase is a better suicide gene than the human herpes virus 1 thymidine kinase
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Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
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Assays for noninvasive imaging of reporter gene expression
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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase
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In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine
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The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).
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New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol
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Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase
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Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes
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Cloning and expression of human deoxycytidine kinase cDNA
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Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
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In vivo human carboxylesterase cDNA gene transfer to activate the prodrug CPT-11 for local treatment of solid tumors
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Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
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21 January 2018
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies
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21 January 2018
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo
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21 January 2018
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
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Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans
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Synergy between the herpes simplex virus tk/ganciclovir prodrug suicide system and the topoisomerase I inhibitor topotecan
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https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene
1 reference
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reference URL
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retrieved
21 January 2018
Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
High-dose cyclophosphamide chemotherapy for recurrent CNS tumors in children.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F%28SICI%291521-2254%28200005%2F06%292%3A3%3C148%3A%3AAID-JGM105%3E3.0.CO%3B2-Q
retrieved
21 January 2018
Identifiers
DOI
10.1002/(SICI)1521-2254(200005/06)2:3<148::AID-JGM105>3.0.CO;2-Q
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
PubMed ID
10894261
1 reference
stated in
Europe PubMed Central
PubMed ID
10894261
retrieved
30 July 2017
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