(Q34022690)

30 July 2017

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title

New insights into apoptosis signaling by Apo2L/TRAIL. (English)

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30 July 2017

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F Gonzalvez

1

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30 July 2017

A Ashkenazi

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

7 June 2010

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30 July 2017

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30 July 2017

29

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30 July 2017

4752-4765

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30 July 2017

34

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https://scigraph.springernature.com/pub.10.1038/onc.2010.221

30 July 2017

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31 March 2020

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Safety and antitumor activity of recombinant soluble Apo2 ligand

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Death-receptor activation halts clathrin-dependent endocytosis

31 March 2020

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The CD95 type I/type II model

31 March 2020

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Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage

31 March 2020

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A unified model for apical caspase activation

31 March 2020

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Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL

31 March 2020

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Genes that mediate breast cancer metastasis to the brain

31 March 2020

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Characterization of cytoplasmic caspase-2 activation by induced proximity.

31 March 2020

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31 March 2020

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31 March 2020

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Activation of initiator caspases through a stable dimeric intermediate

31 March 2020

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Current concepts in apoptosis: the physiological suicide program revisited.

31 March 2020

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Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis

31 March 2020

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31 March 2020

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Cell death: critical control points

31 March 2020

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Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

31 March 2020

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TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

31 March 2020

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

31 March 2020

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TRAIL-R as a negative regulator of innate immune cell responses.

31 March 2020

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Doxorubicin enhances TRAIL-induced cell death via ceramide-enriched membrane platforms

31 March 2020

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31 March 2020

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TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

31 March 2020

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Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.

31 March 2020

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Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL.

31 March 2020

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Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.

31 March 2020

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Apoptosis in human disease: a new skin for the old ceremony?

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

31 March 2020

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TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis

31 March 2020

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Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

31 March 2020

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Role of cardiolipin on tBid and tBid/Bax synergistic effects on yeast mitochondria

31 March 2020

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tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak.

31 March 2020

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Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Ceramide-mediated clustering is required for CD95-DISC formation

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

CD95 Signaling via Ceramide-rich Membrane Rafts

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Mitochondria and apoptosis

31 March 2020

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tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Sensitivity to apoptosis signal, clearance rate, and ultrastructure of fas ligand-induced apoptosis in in vivo adult cardiac cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2010.221

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Inhibition of death receptor signals by cellular FLIP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Trail induces cell migration and invasion in apoptosis-resistant cholangiocarcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

XIAP discriminates between type I and type II FAS-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

CD95's deadly mission in the immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The mitochondrial death/life regulator in apoptosis and necrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Does Apo2L/TRAIL play any physiologic role in osteoclastogenesis?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

DR5 receptor mediates anoikis in human colorectal carcinoma cell lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

31 March 2020

Death receptor signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspases: pharmacological manipulation of cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Apo2L/TRAIL and its death and decoy receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The role of receptor internalization in CD95 signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspases in apoptosis and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of IkappaB kinase and c-Jun N-terminal kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cardiolipin provides specificity for targeting of tBid to mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

A novel receptor for Apo2L/TRAIL contains a truncated death domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Mitochondrial disease: mutations and mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

31 March 2020

Apoptosis in development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Signal integration and diversification through the p62 scaffold protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Apoptosis by death factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Is TRAIL the holy grail of cancer therapy?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

PDTC enables type I TRAIL signaling in type II follicular lymphoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Apoptosis in the development and maintenance of the immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Regulation of TNF-related apoptosis-inducing ligand-mediated death-signal pathway in human beta cells by Fas-associated death domain and nuclear factor kappaB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Identification and characterization of a ligand-independent oligomerization domain in the extracellular region of the CD95 death receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The CD95(APO-1/Fas) DISC and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Structural biology of the Bcl-2 family of proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Back to the future with ubiquitin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Apoptosis and autoimmune disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspase function in neuronal death: delineation of the role of caspases in ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspase-9 and APAF-1 form an active holoenzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Activation of caspase-8 in the Alzheimer's disease brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Palmitoylation of the TRAIL receptor DR4 confers an efficient TRAIL-induced cell death signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Increased expression of cFLIP(L) in colonic adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Role of caspases in male infertility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

IAP proteins: blocking the road to death's door

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspases in Huntington's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Two CD95 (APO-1/Fas) signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Selective knockdown of the long variant of cellular FLICE inhibitory protein augments death receptor-mediated caspase-8 activation and apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Let-7 expression defines two differentiation stages of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Regulation of lymphocyte proliferation and death by FLIP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Investigating the interaction between osteoprotegerin and receptor activator of NF-kappaB or tumor necrosis factor-related apoptosis-inducing ligand: evidence for a pivotal role for osteoprotegerin in regulating two distinct pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Caspase-10 is an initiator caspase in death receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

BID: a novel BH3 domain-only death agonist

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Identification and characterization of a new member of the TNF family that induces apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Death receptor signal transducers: nodes of coordination in immune signaling networks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

The point of no return: mitochondria, caspases, and the commitment to cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.221

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2010.221

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference