(Q34025724)

English

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

DNA methylation

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Gregory Dolnikowski

5

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8 December 2019

Pamela J Bagley

6

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8 December 2019

Oliviero Olivieri

7

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8 December 2019

11

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Jacob Selhub

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8 December 2019

8

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Paul F Jacques

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8 December 2019

Irwin H. Rosenberg

9

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Irwin H Rosenberg

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8 December 2019

author name string

Simonetta Friso

1

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8 December 2019

Sang-Woon Choi

2

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8 December 2019

Domenico Girelli

3

1 reference

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8 December 2019

Joel B Mason

4

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8 December 2019

Roberto Corrocher

10

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8 December 2019

language of work or name

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publication date

2 April 2002

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8 December 2019

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

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8 December 2019

99

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8 December 2019

5606-5611

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8 December 2019

8

1 reference

Europe PubMed Central

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8 December 2019

C(m)C(a/t)GG methylation: a new epigenetic mark in mammalian DNA?

1 reference

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5 July 2018

CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing

1 reference

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5 July 2018

The role of DNA methylation in mammalian epigenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The mechanism of DNA cytosine-5 methylation. Kinetic and mutational dissection of Hhai methyltransferase

1 reference

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5 July 2018

Biological and clinical implications of the MTHFR C677T polymorphism

1 reference

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5 July 2018

Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

1 reference

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5 July 2018

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

1 reference

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5 July 2018

DNA methylation in health and disease

1 reference

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5 July 2018

The DNA methyltransferases of mammals

1 reference

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5 July 2018

The controversy over homocysteine and cardiovascular risk

1 reference

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5 July 2018

5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Folate and carcinogenesis: an integrated scheme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

DNA methylation analysis: a review of current methodologies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Methylation-induced repression--belts, braces, and chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Electrospray ionization mass spectrometry of 5-methyl-2'-deoxycytidine and its determination in urine by liquid chromatography/electrospray ionization tandem mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Epigenetics: regulation through repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Homocysteine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Cancer epigenetics comes of age

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The implications of genetic diversity for nutrient requirements: the case of folate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Alterations in DNA methylation: a fundamental aspect of neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The 677C-->T mutation in the methylenetetrahydrofolate reductase gene: associations with plasma total homocysteine levels and risk of coronary atherosclerotic disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Altered DNA methylation and genome instability: a new pathway to cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Global DNA hypomethylation increases progressively in cervical dysplasia and carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

CpNpG methylation in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Number of CpG islands and genes in human and mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

DNA Methylation and Gene Function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Making sense of laboratory tests of folate status: folate requirements to sustain normality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

CpG-rich islands and the function of DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Folate status assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Inhibition of promoter activity by methylation: possible involvement of protein mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

The essentials of DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

X inactivation, differentiation, and DNA methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

5 July 2018

Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122817

29 October 2018

Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly sensitive and simple liquid chromatographic determination in plasma of B6 vitamers, especially pyridoxal 5'-phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homocysteine and atherothrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of folate form distribution by affinity followed by reversed- phase chromatography with electrical detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphisms in the factor VII gene and the risk of myocardial infarction in patients with coronary artery disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methylation meets genomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA modification mechanisms and gene activity during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrasonically assisted electrospray ionization for LC/MS determination of nucleosides from a transfer RNA digest

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c-myc-specific hypomethylation of colonic DNA in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida

1 reference

https://pubmed.ncbi.nlm.nih.gov/11929966

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.062066299

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

2002PNAS...99.5606F

0 references

release_fdshin7xqfgoraix4sva7b3lyy

1 reference

https://api.fatcat.wiki/v0/release/fdshin7xqfgoraix4sva7b3lyy

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11929966%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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