(Q34048140)

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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

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scholarly article

1 reference

Europe PubMed Central

30 July 2017

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer (English)

1 reference

Europe PubMed Central

30 July 2017

0 references

14

object named as

Rachel Schiff

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Europe PubMed Central

30 July 2017

Ana Maria Gonzalez-Angulo

6

object named as

Ana Maria Gonzalez-Angulo

1 reference

Europe PubMed Central

30 July 2017

Gordon B. Mills

12

object named as

Gordon B Mills

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Europe PubMed Central

30 July 2017

8

object named as

Joe W Gray

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Europe PubMed Central

30 July 2017

Bryan T. Hennessy

3

object named as

Bryan T Hennessy

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Europe PubMed Central

30 July 2017

author name string

Chad J Creighton

1

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Europe PubMed Central

30 July 2017

Xiaoyong Fu

2

1 reference

Europe PubMed Central

30 July 2017

Angelo J Casa

4

1 reference

Europe PubMed Central

30 July 2017

Yiqun Zhang

5

1 reference

Europe PubMed Central

30 July 2017

Ana Lluch

7

1 reference

Europe PubMed Central

30 July 2017

Powell H Brown

9

1 reference

Europe PubMed Central

30 July 2017

Susan G Hilsenbeck

10

1 reference

Europe PubMed Central

30 July 2017

C Kent Osborne

11

1 reference

Europe PubMed Central

30 July 2017

Adrian V Lee

13

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Europe PubMed Central

30 July 2017

publication date

22 June 2010

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Europe PubMed Central

30 July 2017

Breast Cancer Research

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Europe PubMed Central

30 July 2017

12

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Europe PubMed Central

30 July 2017

R40

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Europe PubMed Central

30 July 2017

3

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Europe PubMed Central

30 July 2017

https://scigraph.springernature.com/pub.10.1186/bcr2594

0 references

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

1 reference

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5 July 2018

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

1 reference

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5 July 2018

Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma

1 reference

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5 July 2018

Supervised risk predictor of breast cancer based on intrinsic subtypes

1 reference

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Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis

1 reference

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

1 reference

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5 July 2018

Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer

1 reference

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Molecular profiles of progesterone receptor loss in human breast tumors

1 reference

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Overcoming endocrine resistance in breast cancer: are signal transduction inhibitors the answer?

1 reference

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5 July 2018

Deregulation of the Akt pathway in human cancer

1 reference

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Advances in adjuvant endocrine therapy for postmenopausal women

1 reference

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Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function

1 reference

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Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance

1 reference

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Pharmacodynamic markers of perifosine efficacy

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Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.

1 reference

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The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha

1 reference

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EGFR associated expression profiles vary with breast tumor subtype

1 reference

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

1 reference

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5 July 2018

Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade

1 reference

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5 July 2018

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

1 reference

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Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail

1 reference

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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

1 reference

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5 July 2018

Expression of active Akt protects against tamoxifen-induced apoptosis in MCF-7 Cells

1 reference

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Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

5 July 2018

Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

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Oncogenic PI3K and its role in cancer

1 reference

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Exploiting the PI3K/AKT pathway for cancer drug discovery

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Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy

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Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

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Activated Akt expression in breast cancer: correlation with p53, Hdm2 and patient outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

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Estrogen-receptor biology: continuing progress and therapeutic implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

1 reference

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

1 reference

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5 July 2018

Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway

1 reference

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1 reference

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Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2917035

5 July 2018

Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases

1 reference

https://api.crossref.org/works/10.1186%2FBCR2594

21 January 2018

AKT activation predicts outcome in breast cancer patients treated with tamoxifen

1 reference

https://api.crossref.org/works/10.1186%2FBCR2594

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The association between Akt activation and resistance to hormone therapy in metastatic breast cancer.

1 reference

https://api.crossref.org/works/10.1186%2FBCR2594

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1 reference

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1 reference

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21 January 2018

The dynamics of estrogen receptor status in breast cancer: re-shaping the paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/20569503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PI3K/Akt signaling and hormone resistance in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20569503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20569503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/20569503

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/BCR2594

1 reference

Europe PubMed Central

30 July 2017

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1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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