(Q34075379)

30 July 2017

title

A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease (English)

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30 July 2017

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Zhenning He

1

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30 July 2017

J Eric Russell

series ordinal

2

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30 July 2017

language of work or name

English

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publication date

17 July 2002

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

99

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30 July 2017

issue

16

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30 July 2017

page(s)

10635-10640

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DEVELOPMENTAL HEMOGLOBIN ANOMALIES IN A CHROMOSOMAL TRIPLICATION: D1 TRISOMY SYNDROME

30 July 2017

cites work

1 reference

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Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin

28 July 2018

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Expression, purification, and characterization of human hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knockout mice

28 July 2018

1 reference

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Embryonic hemoglobins are expressed in definitive cells

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124997

Reversal of lethal alpha- and beta-thalassemias in mice by expression of human embryonic globins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124997

The high resolution crystal structure of deoxyhemoglobin S

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124997

Developmental silencing of the embryonic zeta-globin gene: concerted action of the promoter and the 3'-flanking region combined with stage-specific silencing by the transcribed segment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124997

Protein-DNA interactions in the epsilon-globin gene silencer.

28 July 2018

1 reference

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Developmental regulation of the human embryonic beta-like globin gene is mediated by synergistic interactions among multiple tissue- and stage-specific elements

28 July 2018

1 reference

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Identification of two novel regulatory elements within the 5'-untranslated region of the human A gamma-globin gene

28 July 2018

1 reference

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Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

28 July 2018

1 reference

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A dominant control region from the human beta-globin locus conferring integration site-independent gene expression

28 July 2018

1 reference

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Delay in the fetal globin switch in infants of diabetic mothers

28 July 2018

1 reference

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Expression of fully functional tetrameric human hemoglobin in Escherichia coli

28 July 2018

1 reference

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Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

28 July 2018

1 reference

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Hereditary persistence of foetal haemoglobin with β-chain synthesis in cis position (Gγ-β+-HPFH) in a negro family

28 July 2018

1 reference

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Crystal structure of sickle-cell deoxyhemoglobin at 5 A resolution.

28 July 2018

1 reference

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Reselution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=124997

Nucleation-controlled aggregation of deoxyhemoglobin S. Possible difference in the size of nuclei in different phosphate concentrations

28 July 2018

1 reference

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Pathogenesis and treatment of sickle cell disease

28 July 2018

1 reference

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Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy

21 January 2018

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Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease

21 January 2018

1 reference

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Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease

21 January 2018

1 reference

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Gel electrophoretic separation of globin chains

28 October 2018

1 reference

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Autonomous developmental control of human embryonic globin gene switching in transgenic mice.

28 October 2018

1 reference

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Two New Hæmoglobin Variants in a Very Young Human Embryo

28 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

A 3' enhancer contributes to the stage-specific expression of the human beta-globin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Oxygen binding and other physical properties of human hemoglobin made in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Role of beta87 Thr in the beta6 Val acceptor site during deoxy Hb S polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Functional effects of replacing human alpha- and beta-globins with their embryonic globin homologues in defined haemoglobin heterotetramers

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Knockout-transgenic mouse model of sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Pulmonary hypertension in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group

21 January 2018

1 reference

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5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.162269099

21 January 2018

Identifiers

DOI

10.1073/PNAS.162269099

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30 July 2017

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30 July 2017

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