(Q34099799)

31 July 2017

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title

Pharmacogenetics: a tool for individualizing antineoplastic therapy (English)

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31 July 2017

F Innocenti

1

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31 July 2017

L Iyer

series ordinal

2

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31 July 2017

M J Ratain

series ordinal

3

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31 July 2017

publication date

1 November 2000

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Clinical Pharmacokinetics

31 July 2017

published in

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31 July 2017

volume

39

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31 July 2017

issue

5

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31 July 2017

page(s)

315-325

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Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil.

31 July 2017

cites work

1 reference

12 December 2020

Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine uracilurea.

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12 December 2020

Pitfalls in the diagnosis of patients with a partial dihydropyrimidine dehydrogenase deficiency

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12 December 2020

Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia

1 reference

12 December 2020

Racial variability in the UDP-glucuronosyltransferase 1 ( UGT1A1 ) promoter: A balanced polymorphism for regulation of bilirubin metabolism?

1 reference

12 December 2020

Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates.

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12 December 2020

Analysis of thiopurine methyltransferase variant alleles in childhood acute lymphoblastic leukaemia

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12 December 2020

Human thiopurine methyltransferase pharmacogenetics: Gene sequence polymorphisms*

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12 December 2020

Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy*

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12 December 2020

Nomenclature for human DPYD alleles

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12 December 2020

Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).

1 reference

12 December 2020

Putative Role of Dihydropyrimidine Dehydrogenase in the Toxic Side Effect of 5-Fluorouracil in Colorectal Cancer Patients

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12 December 2020

Factors involved in clinical pharmacology variability in oncology (review).

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12 December 2020

Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients

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12 December 2020

Structural organization of the human dihydropyrimidine dehydrogenase gene

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12 December 2020

Severe fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency

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12 December 2020

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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12 December 2020

Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

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12 December 2020

6-Mercaptopurine cumulative dose: a critical factor of maintenance therapy in average risk childhood acute lymphoblastic leukemia.

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12 December 2020

Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan

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12 December 2020

Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer

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12 December 2020

UGT1*1 genotyping in a Canadian Inuit population

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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12 December 2020

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

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12 December 2020

Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population

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12 December 2020

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

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12 December 2020

Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity

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12 December 2020

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

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12 December 2020

Severe CPT-11 toxicity in patients with Gilbert's syndrome: Two case reports

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12 December 2020

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome

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12 December 2020

Thiopurine methyltransferase deficiency in childhood lymphoblastic leukaemia: 6-mercaptopurine dosage strategies

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12 December 2020

Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.

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12 December 2020

6-Mercaptopurine dose escalation and its effect on drug tolerance in childhood lymphoblastic leukaemia

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12 December 2020

Population studies on Gilbert's syndrome

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12 December 2020

Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients

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12 December 2020

Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy Taiwanese

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12 December 2020

The UGT1A1*28 allele is relatively rare in a Japanese population

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12 December 2020

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

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12 December 2020

Paradoxical relationship between acetylator phenotype and amonafide toxicity

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12 December 2020

Severe 5‐fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G→A point mutation

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12 December 2020

A point mutation in an invariant splice donor site leads to exon skipping in two unrelated Dutch patients with dihydropyrimidine dehydrogenase deficiency

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12 December 2020

Thiopurine drugs in the treatment of childhood leukaemia: the influence of inherited thiopurine methyltransferase activity on drug metabolism and cytotoxicity

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12 December 2020

Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.

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12 December 2020

Phase I study of amonafide dosing based on acetylator phenotype.

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12 December 2020

Inherited variations in drug-metabolizing enzymes: significance in clinical oncology

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12 December 2020

Severe 5-fluorouracil toxicity in a patient with decreased dihydropyrimidine dehydrogenase activity

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12 December 2020

Thiopurine methyltransferase alleles in British and Ghanaian populations

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12 December 2020

Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities

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12 December 2020

Known variant DPYD alleles do not explain DPD deficiency in cancer patients

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12 December 2020

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

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12 December 2020

Identification of a new metabolite of CPT-11 (irinotecan): pharmacological properties and activation to SN-38

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12 December 2020

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

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12 December 2020

Prolonged severe 5-fluorouracil-associated neurotoxicity in a patient with dihydropyrimidine dehydrogenase deficiency

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12 December 2020

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

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12 December 2020

Pharmacokinetics and metabolism of the antitumor drug amonafide (NSC-308847) in humans

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12 December 2020

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

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12 December 2020

Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity

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12 December 2020

The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia

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12 December 2020

Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism

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12 December 2020

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

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12 December 2020

Pharmacogenetics and cancer chemotherapy

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12 December 2020

Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia

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12 December 2020

Thiopurine methyltransferase activity in American white subjects and black subjects

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12 December 2020

Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia.

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12 December 2020

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

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12 December 2020

Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency

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12 December 2020

Three Japanese patients with Crigler-Najjar syndrome type I carry an identical nonsense mutation in the gene for UDP-glucuronosyltransferase

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12 December 2020

Genetic control of isoniazid metabolism in man

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12 December 2020

Population study of dihydropyrimidine dehydrogenase in cancer patients

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12 December 2020

UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrations

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12 December 2020

Purine substrates for human thiopurine methyltransferase

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12 December 2020

Decreased dihydropyrimidine dehydrogenase activity in a population of patients with breast cancer: implication for 5-fluorouracil-based chemotherapy

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12 December 2020

Molecular pathology of Crigler-Najjar type I and II and Gilbert's syndromes.

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12 December 2020

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

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12 December 2020

A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine

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12 December 2020

Dihydropyrimidine dehydrogenase deficiency and fluorouracil-related toxicity

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12 December 2020

Link between dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells and liver

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12 December 2020

Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2

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12 December 2020

Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism

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12 December 2020

Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients

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12 December 2020

Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity

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12 December 2020

Characterization of dihydropyrimidine dehydrogenase in human colorectal tumours

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12 December 2020

Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy

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12 December 2020

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

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12 December 2020

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infus

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12 December 2020

Characterization of the human dihydropyrimidine dehydrogenase gene

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12 December 2020

Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals.

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12 December 2020

Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosa

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12 December 2020

Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency.

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12 December 2020

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

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12 December 2020

Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency

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12 December 2020

Neonatal hyperbilirubinemia and a common mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese

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12 December 2020

Cloning and initial characterization of the human DPYD gene promoter

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12 December 2020

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

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12 December 2020

Intratumoral expression of thymidylate synthase and dihydropyrimidine dehydrogenase in non-small cell lung cancer patients treated with 5-FU-based chemotherapy

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12 December 2020

Correlation between dihydropyrimidine dehydrogenase activity in peripheral mononuclear cells and systemic clearance of fluorouracil in cancer patients

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12 December 2020

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

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12 December 2020

Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells

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12 December 2020

(TA)8 allele in the UGT1A1 gene promoter of a Caucasian with Gilbert's syndrome

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12 December 2020

Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate

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12 December 2020

Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population

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12 December 2020

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

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12 December 2020

Technologies for detecting genetic polymorphisms in pharmacogenomics

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12 December 2020

Dihydropyrimidine dehydrogenase activity in cancer patients

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12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

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12 December 2020

The genetic basis of Gilbert's syndrome

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12 December 2020

Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity

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12 December 2020

10.2165/00003088-200039050-00001

Identifiers

DOI

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Dimensions Publication ID

31 July 2017

1011047619

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