(Q34105795)

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Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

scientific article

Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model11Published on the World Wide Web on 10 October 2000.

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

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vector-borne disease

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Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

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Anders Björklund

1

object named as

Björklund A

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Kirik D

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

Rosenblad C

3

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Europe PubMed Central

PubMed publication ID

31 July 2017

Georgievska B

4

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Europe PubMed Central

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31 July 2017

Lundberg C

5

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Europe PubMed Central

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31 July 2017

Mandel RJ

6

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31 July 2017

language of work or name

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publication date

1 December 2000

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Europe PubMed Central

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31 July 2017

886

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Europe PubMed Central

PubMed publication ID

31 July 2017

1-2

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Europe PubMed Central

PubMed publication ID

31 July 2017

82-98

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Europe PubMed Central

PubMed publication ID

31 July 2017

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Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF.

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Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease.

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Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease

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Adenovirus-mediated transgene expression in nonhuman primate brain

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The early diagnosis of Parkinson's disease.

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Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat.

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Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

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PET studies of functional compensation in a primate model of Parkinson's disease

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Ageing and Parkinson's disease: substantia nigra regional selectivity

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Lentiviral vectors: regulated gene expression

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Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat.

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Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor

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Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system.

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Neuron-specific transduction in the rat septohippocampal or nigrostriatal pathway by recombinant adeno-associated virus vectors

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Lentiviral gene transfer to the nonhuman primate brain

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Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease

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Glial cell line-derived neurotrophic factor induces the dopaminergic and cholinergic phenotype and increases locomotor activity in aged Fischer 344 rats

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Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease

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Adeno-associated virus-mediated gene transfer to the brain: duration and modulation of expression

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Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease.

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Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease

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Identifiers

10.1016/S0006-8993(00)02915-2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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