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Role of transforming growth factor beta in cancer
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Role of transforming growth factor beta in cancer
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
author name string
Pasche B
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
publication date
1 February 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
published in
Journal of Cellular Physiology
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
volume
186
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
page(s)
153-168
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
issue
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
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Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.
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TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis
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Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
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Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome
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TGF-beta inhibits proliferation of and promotes differentiation of human promonocytic leukemia cells
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Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
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Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.
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A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor
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The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors
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21 January 2018
TGF-B2 and soluble p55 TNFR modulate VCAM-1 expression in glioma cells and brain derived endothelial cells
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Microsatellite alterations in plasma DNA of small cell lung cancer patients.
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Mechanism of TGFbeta receptor inhibition by FKBP12
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21 January 2018
Frequent aberration of the transforming growth factor-beta receptor II gene in cell lines but no apparent mutation in pre-invasive and invasive carcinomas of the uterine cervix.
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21 January 2018
Thrombospondin-1 is a major activator of TGF-beta1 in vivo
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21 January 2018
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
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21 January 2018
STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling
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The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
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Differential response of cervical intraepithelial and cervical carcinoma cell lines to transforming growth factor-beta 1.
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21 January 2018
Loss of functional cell surface transforming growth factor beta (TGF-beta) type 1 receptor correlates with insensitivity to TGF-beta in chronic lymphocytic leukemia
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21 January 2018
HPV16 E6 oncoprotein stimulates the transforming growth factor-beta 1 promoter in fibroblasts through a specific GC-rich sequence
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21 January 2018
Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer
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21 January 2018
Decreased expression of transforming growth factor beta receptors on head and neck squamous cell carcinoma tumor cells
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21 January 2018
Transforming growth factor-beta type II receptor confers tumor suppressor activity in murine renal carcinoma (Renca) cells
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21 January 2018
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation
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Microsatellite instability in squamous cell carcinoma of the head and neck.
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21 January 2018
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
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21 January 2018
Microsatellite instability in hematologic malignancies
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21 January 2018
Frameshift mutations in TGFbetaRII, IGFIIR, BAX, hMSH3 and hMSH6 are absent in lung cancers
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21 January 2018
Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer.
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21 January 2018
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.
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21 January 2018
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
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21 January 2018
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
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21 January 2018
Effects of type beta transforming growth factor in combination with retinoic acid or tumor necrosis factor on proliferation of a human glioblastoma cell line and clonogenic cells from freshly resected human brain tumors.
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21 January 2018
Inactivation of the transforming growth factor beta type II receptor in human small cell lung cancer cell lines
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21 January 2018
Mutations in the SMAD4/DPC4 gene in juvenile polyposis
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21 January 2018
Cell cycle and transcriptional control of human myeloid leukemic cells by transforming growth factor beta
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21 January 2018
Analysis of the Smad2 gene in hematological malignancies.
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21 January 2018
Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression
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21 January 2018
Resistance to TGF-beta1 correlates with a reduction of TGF-beta type II receptor expression in Burkitt's lymphoma and Epstein-Barr virus-transformed B lymphoblastoid cell lines
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21 January 2018
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines
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21 January 2018
TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300
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21 January 2018
Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer
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21 January 2018
IGFBP-3 mediates TGF beta 1 proliferative response in colon cancer cells
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21 January 2018
Cytokine expression of transforming growth factor-beta2 and interleukin-10 in squamous cell carcinomas of the head and neck. Comparison of tissue expression and serum levels
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21 January 2018
Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic cancer
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21 January 2018
The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
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21 January 2018
Processing of the transforming growth factor beta type I and II receptors. Biosynthesis and ligand-induced regulation
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21 January 2018
Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma
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21 January 2018
A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras
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21 January 2018
Serum transforming growth factor-beta 1 is related to the degree of immunoparesis in patients with multiple myeloma
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21 January 2018
A proliferative effect of transforming growth factor-beta1 on a human prostate cancer cell line, TSU-Pr1.
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21 January 2018
Expression and mutational analysis of the MADR2/Smad2 gene in human prostate cancer.
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21 January 2018
Transforming growth factor-beta responsiveness in DPC4/SMAD4-null cancer cells
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21 January 2018
Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer
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21 January 2018
Defective angiogenesis in mice lacking endoglin
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21 January 2018
Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase
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21 January 2018
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes
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21 January 2018
Ubiquitin-dependent degradation of TGF-beta-activated smad2.
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21 January 2018
Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system
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21 January 2018
HNPCC associated with germline mutation in the TGF-beta type II receptor gene.
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21 January 2018
Two divergent signaling pathways for TGF-beta separated by a mutation of its type II receptor gene
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21 January 2018
The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
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21 January 2018
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
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21 January 2018
TGF-beta signal transduction
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21 January 2018
Transcriptional control by the TGF-beta/Smad signaling system
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21 January 2018
Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
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21 January 2018
Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma.
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21 January 2018
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
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21 January 2018
The prognostic significance of transforming growth factors in human breast cancer
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21 January 2018
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
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21 January 2018
Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer.
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Crossref
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21 January 2018
TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
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Crossref
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21 January 2018
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
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21 January 2018
Cloning of a cDNA encoding the human transforming growth factor-beta type II receptor: heterogeneity of the mRNA
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21 January 2018
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
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21 January 2018
Microsatellite instability and loss of heterozygosity in melanoma.
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21 January 2018
Down-regulated expression of transforming growth factor beta 1 mRNA in endometrial carcinoma
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21 January 2018
Mammary tumor suppression by transforming growth factor beta 1 transgene expression
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21 January 2018
Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V)beta(3) integrin expression.
1 reference
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Crossref
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21 January 2018
Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion
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21 January 2018
Microsatellite instability in human non-melanoma and melanoma skin cancer
1 reference
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Crossref
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21 January 2018
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas
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retrieved
21 January 2018
The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
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21 January 2018
In situ analysis of transforming growth factor-beta s (TGF-beta 1, TGF-beta 2, TGF-beta 3), and TGF-beta type II receptor expression in malignant melanoma.
1 reference
stated in
Crossref
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21 January 2018
Chemical hepatocarcinogenesis in transgenic mice overexpressing mature TGF beta-1 in liver.
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21 January 2018
Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.
1 reference
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Crossref
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21 January 2018
DPC4/SMAD4 gene alterations in human cancer, and their functional implications
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21 January 2018
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
1 reference
stated in
Crossref
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21 January 2018
Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA.
1 reference
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Crossref
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21 January 2018
Glucocorticoid receptor inhibits transforming growth factor-beta signaling by directly targeting the transcriptional activation function of Smad3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
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21 January 2018
Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
1 reference
stated in
Crossref
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21 January 2018
Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
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21 January 2018
SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
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21 January 2018
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
1 reference
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Crossref
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21 January 2018
Gastro-intestinal tumorigenesis in Smad4 mutant mice
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21 January 2018
Development and validation of the Cancer Dyspnoea Scale: a multidimensional, brief, self-rating scale
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21 January 2018
Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency.
1 reference
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Crossref
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21 January 2018
Does mutation of transforming growth factor-beta type II receptor gene play an important role in colorectal polyps?
1 reference
stated in
Crossref
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21 January 2018
Analyses of microsatellite instability and the transforming growth factor-beta receptor type II gene mutation in sporadic human gastrointestinal cancer.
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Crossref
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21 January 2018
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
1 reference
stated in
Crossref
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21 January 2018
Disruption of the antiproliferative TGF-beta signaling pathways in human pancreatic cancer cells.
1 reference
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Crossref
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21 January 2018
Transfection of the type I TGF-beta receptor restores TGF-beta responsiveness in pancreatic cancer.
1 reference
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Crossref
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21 January 2018
Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells
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Crossref
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21 January 2018
Transforming growth factor-beta1 and prostate cancer
1 reference
stated in
Crossref
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21 January 2018
A Smad transcriptional corepressor
1 reference
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Crossref
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21 January 2018
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Elevated serum transforming growth factor beta1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM.
1 reference
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Crossref
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retrieved
21 January 2018
Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type beta transforming growth factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
retrieved
21 January 2018
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.
1 reference
stated in
Crossref
reference URL
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21 January 2018
Ovarian carcinoma cell cultures are resistant to TGF-beta1-mediated growth inhibition despite expression of functional receptors
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
retrieved
21 January 2018
Disrupted transforming growth factor-beta signaling and deregulated growth in human biliary tract cancer cells.
1 reference
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Crossref
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retrieved
21 January 2018
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cel
1 reference
stated in
Crossref
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21 January 2018
Regulation of Smad signalling by protein associations and signalling crosstalk
1 reference
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Crossref
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21 January 2018
DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination
1 reference
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retrieved
21 January 2018
Mutations in a 10-bp polyadenine repeat of transforming growth factor β-receptor type II gene is an infrequent event in human epithelial ovarian cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2F1097-4652%28200002%29186%3A2%3C153%3A%3AAID-JCP1016%3E3.0.CO%3B2-J
retrieved
21 January 2018
Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer.
1 reference
stated in
Crossref
reference URL
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retrieved
21 January 2018
Identifiers
DOI
10.1002/1097-4652(200002)186:2<153::AID-JCP1016>3.0.CO;2-J
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
PubMed ID
11169452
1 reference
stated in
Europe PubMed Central
PubMed ID
11169452
retrieved
31 July 2017
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