(Q34144557)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

review article

1 reference

title

RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

ChEBI release 2020-05-28

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

author name string

R W Clarke

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

publication date

1 January 2002

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

CNS Neuroscience & Therapeutics

12 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

issue

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

177-192

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors

12 November 2019

cites work

1 reference

12 December 2020

Comparison of the effects of acute and subchronic administration of atipamezole on reaction to novelty and active avoidance learning in rats

1 reference

12 December 2020

alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role

1 reference

12 December 2020

Tonic adrenergic and serotonergic inhibition of a withdrawal reflex in rabbits subjected to different levels of surgical preparation.

1 reference

12 December 2020

Yohimbine interacts with the dopaminergic system to reverse sexual satiation: further evidence for a role of sexual motivation in sexual exhaustion.

1 reference

12 December 2020

Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice

1 reference

12 December 2020

Pharmacologic and molecular discrimination of I2-imidazoline receptor subtypes

1 reference

12 December 2020

Spinal systems and pain processing: development of novel analgesic drugs with mechanistically defined models

1 reference

12 December 2020

Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor

1 reference

12 December 2020

Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?

1 reference

12 December 2020

Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo

1 reference

12 December 2020

Modulation of sibutramine-induced increases in extracellular noradrenaline concentration in rat frontal cortex and hypothalamus by alpha2-adrenoceptors.

1 reference

12 December 2020

The antinociceptive effect of the mu-opioid fentanyl is reduced in the presence of the alpha(2)-adrenergic antagonist idazoxan in inflammation

1 reference

12 December 2020

Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors

1 reference

12 December 2020

Moxonidine, a selective imidazoline/alpha(2) adrenergic receptor agonist, synergizes with morphine and deltorphin II to inhibit substance P-induced behavior in mice

1 reference

12 December 2020

Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism

1 reference

12 December 2020

The role of 5-HT(1A)-receptors in fentanyl-induced bulbospinal inhibition of a spinal withdrawal reflex in the rabbit.

1 reference

12 December 2020

Synaptic control of motoneuronal excitability.

1 reference

12 December 2020

Hyperphagic effect of novel compounds with high affinity for imidazoline I(2) binding sites

1 reference

12 December 2020

Inverse agonism at alpha(2)-adrenoceptors in native tissue

1 reference

12 December 2020

Imidazoline I2-receptors and spinal reflexes in the decerebrated rabbit

1 reference

12 December 2020

In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor

1 reference

12 December 2020

Behavioral effects of the alpha(2)-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats

1 reference

12 December 2020

Clinical uses of alpha2 -adrenergic agonists

1 reference

12 December 2020

Inverse agonist activity at the alpha(2A)-adrenergic receptor.

1 reference

12 December 2020

Adaptive changes in withdrawal reflexes after noxious stimulation at the heel and the toes in the decerebrated rabbit.

1 reference

12 December 2020

Respective contributions of alpha-adrenergic and non-adrenergic mechanisms in the hypotensive effect of imidazoline-like drugs

1 reference

12 December 2020

Role of the alpha(1)- and alpha(2)-adrenoceptors of the paraventricular nucleus on the water and salt intake, renal excretion, and arterial pressure induced by angiotensin II injection into the medial septal area

1 reference

12 December 2020

Endogenous adrenergic control of reflexes evoked by mechanical stimulation of the heel in the decerebrated rabbit.

1 reference

12 December 2020

Influence of idazoxan on analgesia, tolerance, and physical dependence of morphine in mice and rats in vivo

1 reference

12 December 2020

Presynaptic autoreceptors in the third decade: focus on alpha2-adrenoceptors

1 reference

12 December 2020

Alpha-adrenoceptor subtypes

1 reference

12 December 2020

Alpha 2-adrenoceptor antagonists: effects on ejaculation, penile erection and pelvic thrusting behavior in dogs

1 reference

12 December 2020

I1 receptors, cardiovascular function, and metabolism

1 reference

12 December 2020

Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.

1 reference

12 December 2020

Pharmacological prospects for alpha 2-adrenoceptor antagonist therapy

1 reference

12 December 2020

Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine

1 reference

12 December 2020

Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain

1 reference

12 December 2020

Quantification of in vivo binding of [3H]RX 821002 in rat brain: evaluation as a radioligand for central alpha 2-adrenoceptors.

1 reference

12 December 2020

Alpha-2A is the predominant alpha-2 adrenergic receptor subtype in human spinal cord

1 reference

12 December 2020

An analysis of adrenergic influences on the sural-gastrocnemius reflex of the decerebrated rabbit

1 reference

12 December 2020

Keeping an eye on the I site: imidazoline-preferring receptors

1 reference

12 December 2020

3HRauwolscine behaves as an agonist for the 5-HTa receptors in human frontal cortex membranes

1 reference

12 December 2020

The effects of idazoxan and other α2-adrenoceptor antagonists on food and water intake in the rat

1 reference

12 December 2020

The projections of locus coeruleus neurons to the spinal cord

1 reference

12 December 2020

Descending noradrenergic influences on pain

1 reference

12 December 2020

Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2-adrenoceptor antagonist--a randomized, double-blind cross-over study in healthy male volunteers

1 reference

12 December 2020

Identification of ?(2) adrenergic receptors in human frontal cortex membranes by binding of [(3)H]RX 821002, the 2-methoxy analog of [(3)H]idazoxan

1 reference

12 December 2020

[3H]rauwolscine labels alpha 2-adrenoceptors and 5-HT1A receptors in human cerebral cortex

1 reference

12 December 2020

[3H]idazoxan binding at non-alpha 2-adrenoceptors in rabbit adipocyte membranes

1 reference

12 December 2020

[3H]RX821002: a new tool for the identification of α2A-adrenoceptors

1 reference

12 December 2020

Are there multiple imidazoline binding sites?

1 reference

12 December 2020

Alpha-adrenoreceptor reagents. 3. Synthesis of some 2-substituted 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists

1 reference

12 December 2020

Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists

1 reference

12 December 2020

Pharmacological profile of a new potent and specific alpha 2-adrenoceptor antagonist, L-657,743.

1 reference

12 December 2020

Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit

1 reference

12 December 2020

Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medulla

1 reference

12 December 2020

[3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes

1 reference

12 December 2020

Comparison of the ?-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine

1 reference

12 December 2020

Effect of intrathecally administered noradrenergic antagonists on nociception in the rat.

1 reference

12 December 2020

Comparison of the binding activities of some drugs on alpha 2A, alpha 2B and alpha 2C-adrenoceptors and non-adrenergic imidazoline sites in the guinea pig.

1 reference

12 December 2020

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications

1 reference

12 December 2020

.alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. Part 1. Molecular Biology and Adrenoceptor Subclassification

1 reference

12 December 2020

I1-imidazoline receptors. Definition, characterization, distribution, and transmembrane signaling

1 reference

12 December 2020

Nonadrenergic binding of [3H]atipamezole in rat lung. A novel imidazole binding site?

1 reference

12 December 2020

Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines

1 reference

12 December 2020

Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes.

1 reference

12 December 2020

Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs

1 reference

12 December 2020

The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.

1 reference

12 December 2020

A pharmacodynamic study of the alpha 2-adrenergic receptor antagonist ethoxyidazoxan in healthy volunteers

1 reference

12 December 2020

Enhanced alpha-2 adrenergic controls and spinal morphine potency in inflammation.

1 reference

12 December 2020

Discrimination and pharmacological characterization of I2-imidazoline sites with [3H]idazoxan and alpha-2 adrenoceptors with [3H]RX821002 (2-methoxy idazoxan) in the human and rat brains

1 reference

12 December 2020

Motor and cardiovascular effects of selective α2-adrenoceptor antagonists in the decerebrated rabbit

1 reference

12 December 2020

Molecular pharmacology of alpha 2-adrenoceptor subtypes

1 reference

12 December 2020

Bulbospinal catecholamine neurones and sympathetic pattern generation

1 reference

12 December 2020

RS-45041-190: a selective, high-affinity ligand for I2 imidazoline receptors.

1 reference

12 December 2020

A re-evaluation of the role of alpha 2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat.

1 reference

12 December 2020

Antinociceptive actions of intrathecal xylazine: interactions with spinal cord opioid pathways

1 reference

12 December 2020

Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors

1 reference

12 December 2020

Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats

1 reference

12 December 2020

The elusive family of imidazoline binding sites

1 reference

12 December 2020

[3H]dexmedetomidine, an alpha 2-adrenoceptor agonist, detects a novel imidazole binding site in adult rat spinal cord

1 reference

12 December 2020

An I2 imidazoline ligand, RS 45041, potentiates hyperalgesia in acute arthritis

1 reference

12 December 2020

Alpha 2-adrenoceptor subtypes in the human brain: a pharmacological delineation of [3H]RX-821002 binding to membranes and tissue sections.

1 reference

12 December 2020

The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain

1 reference

12 December 2020

Spinal 5-HT-receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit.

1 reference

12 December 2020

[3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney

1 reference

12 December 2020

Evaluation in rat of RS-79948-197 as a potential PET ligand for central alpha 2-adrenoceptors.

1 reference

12 December 2020

Effects of alpha 2-adrenoceptor antagonists and imidazoline2-receptor ligands on neuronal damage in global ischaemia in the rat

1 reference

12 December 2020

Pharmacological characterization of I1 and I2 imidazoline receptors in human striatum

1 reference

12 December 2020

Identification of ligands selective for central I2-imidazoline binding sites

1 reference

12 December 2020

The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

1 reference

12 December 2020

BU-224 produces spinal antinociception as an agonist at imidazoline I2 receptors

1 reference

12 December 2020

Quantification of alpha2A and alpha2C adrenoceptors in the rat striatum and in different regions of the spinal cord

1 reference

12 December 2020

Different apparent modes of inhibition of alpha2A-adrenoceptor by alpha2-adrenoceptor antagonists

1 reference

12 December 2020

Autoradiographic studies of central alpha 2A- and alpha 2C-adrenoceptors in the rat using [3H]MK912 and subtype-selective drugs

1 reference

12 December 2020

Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites?

1 reference

12 December 2020

Enhancement and depression of spinal reflexes by 8-hydroxy-2-(di-n-propylamino)tetralin in the decerebrated and spinalized rabbit: involvement of 5-HT1A- and non-5-HT1A-receptors

1 reference

12 December 2020

Evaluation of the effects of a specific alpha 2-adrenoceptor antagonist, atipamezole, on alpha 1- and alpha 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine

1 reference

12 December 2020

Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release

1 reference

12 December 2020

Identification and characterization of non-adrenergic binding sites in insulin-secreting cells with the imidazoline RX821002.

1 reference

12 December 2020

[3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine

1 reference

12 December 2020

Effect of RX 821002 at 5-HT1A-receptors in rabbit spinal cord in vivo

1 reference

12 December 2020

Protean agonism at alpha2A-adrenoceptors

1 reference

12 December 2020

Differential distribution of alpha2A and alpha2C adrenergic receptor immunoreactivity in the rat spinal cord.

1 reference

12 December 2020

Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors

1 reference

12 December 2020

Attenuation of tolerance to opioid-induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands.

1 reference

12 December 2020

'Seeing through a glass darkly': casting light on imidazoline 'I' sites

1 reference

12 December 2020

Subtypes of functional alpha1- and alpha2-adrenoceptors.

1 reference

12 December 2020

The involvement of bulbospinal pathways in fentanyl-induced inhibition of spinal withdrawal reflexes in the decerebrated rabbit

1 reference

12 December 2020

10.1111/J.1527-3458.2002.TB00222.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12177687%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

PubMed publication ID

12177687

1 reference