(Q34163311)

31 July 2017

1 reference

title

In-vivo and in-vitro models of type 2 diabetes in pharmaceutical drug discovery (English)

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31 July 2017

0 references

1 reference

Reed MJ

1

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31 July 2017

Scribner KA

series ordinal

2

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31 July 2017

publication date

1 March 1999

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Diabetes, Obesity and Metabolism

31 July 2017

published in

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31 July 2017

volume

1

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31 July 2017

issue

2

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31 July 2017

page(s)

75-86

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From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM.

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

An ascochlorin derivative, AS-6, reduces insulin resistance in the genetically obese diabetic mouse, db/db.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Human plasma leptin in obese subjects and diabetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Plasma leptin concentrations do not appear to decrease insulin-mediated glucose disposal or glucose-stimulated insulin secretion in women with normal glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Studies on new acidic azoles as glucose-lowering agents in obese, diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones as antihyperglycemic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Meta-chlorophenylpiperazine attenuates formalin-induced nociceptive responses through 5-HT1/2 receptors in both normal and diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2-phenoxy-3-phenylpropanoic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

The metabolic effects of pokeweed mitogen in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Extrapancreatic effects of sulfonylureas--a comparison between glimepiride and conventional sulfonylureas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Nongenetic mouse models of non-insulin-dependent diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Transgenic approaches to the pathogenesis of NIDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide Y and leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Pioglitazone time-dependently reduces tumour necrosis factor-alpha level in muscle and improves metabolic abnormalities in Wistar fatty rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Normalization of impaired glucose tolerance by the short-acting hypoglycemic agent calcium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl)propionate dihydrate (KAD-1229) in non-insulin-dependent diabetes mellitus rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Effect of a non-sulphonylurea hypoglycaemic agent, KAD-1229 on hormone secretion in the isolated perfused pancreas of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneously hypertensive rat complicated with hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Hypoglycaemic and insulinotropic effects of a novel oral antidiabetic agent, (-)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Cardiovascular effects of conventional sulfonylureas and glimepiride

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

The antidiabetic agent thiazolidinedione stimulates the interaction between PPAR gamma and CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

The antihyperglycemic agent englitazone prevents the defect in glucose transport in rats fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Possibility of distinct insulin-signaling pathways beyond phosphatidylinositol 3-kinase-mediating glucose transport and lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Sulfated glycans stimulate endocytosis of the cellular isoform of the prion protein, PrPC, in cultured cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1463-1326.1999.00014.X

10.1046/J.1463-1326.1999.00014.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference