(Q34184917)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

review article

1 reference

title

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Richard A. Franklin

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

James A. McCubrey

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Chang F

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Lee JT

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Navolanic PM

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Steelman LS

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Shelton JG

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

publication date

1 March 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

number of pages

14

1 reference

inferred from page(s)

published in

Leukemia

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

page(s)

590-603

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.leu.2402824

1 November 2019

exact match

0 references

cites work

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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7 January 2021

Kinases: positive and negative regulators of apoptosis.

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7 January 2021

Suppression of apoptosis: role in cell growth and neoplasia

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7 January 2021

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

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7 January 2021

Serine/threonine phosphorylation in cytokine signal transduction

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7 January 2021

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

1 reference

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7 January 2021

Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

1 reference

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7 January 2021

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia

1 reference

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7 January 2021

Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies

1 reference

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7 January 2021

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

1 reference

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7 January 2021

Overexpression of phosphatidylinositol 3-kinase in human lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The protein kinase B/Akt signalling pathway in human malignancy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphatidylinositol 3' kinase: one of the effectors of Ras.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

PKB/AKT: functional insights from genetic models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Downstream signalling events regulated by phosphatidylinositol 3-kinase activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cyclin-dependent kinases: engines, clocks, and microprocessors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Multiple ras effector pathways contribute to G(1) cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Akt serine threonine kinase regulates platelet-derived growth factor-induced DNA synthesis in glomerular mesangial cells: regulation of c-fos AND p27(kip1) gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

p21 is a universal inhibitor of cyclin kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Inhibition of cyclin-dependent kinases by p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The N-terminal domains of cyclin-dependent kinase inhibitory proteins block the phosphorylation of cdk2/Cyclin E by the CDK-activating kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Decorin-mediated signal transduction in endothelial cells. Involvement of Akt/protein kinase B in up-regulation of p21(WAF1/CIP1) but not p27(KIP1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Proteasome-dependent regulation of p21WAF1/CIP1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

A molecular mechanism for the effect of lithium on development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Bone morphogenetic protein 2 inhibits platelet-derived growth factor-induced c-fos gene transcription and DNA synthesis in mesangial cells. Involvement of mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Abrogation of c-Raf expression induces apoptosis in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Isoform-specific localization of A-RAF in mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Combined effects of aberrant MEK1 activity and BCL2 overexpression on relieving the cytokine dependency of human and murine hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Regulation of Raf-Akt Cross-talk

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The ERK MAP kinase pathway mediates induction of SGK (serum- and glucocorticoid-inducible kinase) by growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Follicle-Stimulating Hormone (FSH) Stimulates Phosphorylation and Activation of Protein Kinase B (PKB/Akt) and Serum and Glucocorticoid-Induced Kinase (Sgk): Evidence for A Kinase-Independent Signaling by FSH in Granulosa Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Oxidative stress and vanadate induce tyrosine phosphorylation of phosphoinositide-dependent kinase 1 (PDK1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Differentiation and malignant transformation: two roads diverged in a wood

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

An activated mutant of R-Ras inhibits cell death caused by cytokine deprivation in BaF3 cells in the presence of IGF-I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402824

7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

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7 January 2021

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

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7 January 2021

Mechanisms of apoptosis by the tyrphostin AG957 in hematopoietic cells

1 reference

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7 January 2021

Mechanism of action of the immunosuppressant rapamycin

1 reference

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7 January 2021

Downregulation of Akt1 inhibits anchorage-independent cell growth and induces apoptosis in cancer cells

1 reference

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7 January 2021

Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival

1 reference

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7 January 2021

Blocking oncogenic Ras signaling for cancer therapy

1 reference

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7 January 2021

Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

1 reference

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7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

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7 January 2021

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

1 reference

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7 January 2021

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

1 reference

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7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

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7 January 2021

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

1 reference

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7 January 2021

v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras

1 reference

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7 January 2021

A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion

1 reference

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7 January 2021

Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

1 reference

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7 January 2021

Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

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7 January 2021

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

1 reference

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7 January 2021

Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402824

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12646949%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 November 2019

0 references

1 reference