(Q34189367)

31 July 2017

title

The cellular delivery of antisense oligonucleotides and ribozymes (English)

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31 July 2017

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M D. Hughes

1

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31 July 2017

M Hussain

2

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31 July 2017

Q Nawaz

3

1 reference

31 July 2017

P Sayyed

4

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31 July 2017

S Akhtar

5

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31 July 2017

publication date

1 March 2001

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31 July 2017

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31 July 2017

volume

6

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31 July 2017

issue

6

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31 July 2017

page(s)

303-315

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Preclinical and clinical pharmacology of antisense oligonucleotides

31 July 2017

cites work

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7 January 2021

In vivo studies with antisense oligonucleotides

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7 January 2021

The delivery of antisense therapeutics

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7 January 2021

On finding all suboptimal foldings of an RNA molecule

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7 January 2021

Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries

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7 January 2021

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

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7 January 2021

Selecting optimal antisense reagents

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7 January 2021

Antisense technology: selection and delivery of optimally acting antisense oligonucleotides

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7 January 2021

Potent antisense oligonucleotides to the human multidrug resistance-1 mRNA are rationally selected by mapping RNA-accessible sites with oligonucleotide libraries

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7 January 2021

Rapid determination and quantitation of the accessibility to native RNAs by antisense oligodeoxynucleotides in murine cell extracts

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7 January 2021

Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

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7 January 2021

DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale

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7 January 2021

Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids

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7 January 2021

Selecting effective antisense reagents on combinatorial oligonucleotide arrays

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7 January 2021

Oligodeoxynucleotide stability in subcellular extracts and culture media

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7 January 2021

Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera

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7 January 2021

Oligonucleotide analogues as potential chemotherapeutic agents

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7 January 2021

Antisense oligonucleotides

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7 January 2021

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

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7 January 2021

Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells

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7 January 2021

Absorption of antisense oligonucleotides in rat intestine: effect of chemistry and length

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7 January 2021

Attenuation of cytomegalovirus-induced endothelial intercellular adhesion molecule-1 mRNA/protein expression and T lymphocyte adhesion by a 2'-O-methoxyethyl antisense oligonucleotide.

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7 January 2021

In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha

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7 January 2021

Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb

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7 January 2021

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance

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7 January 2021

Intracellular metabolism of a 2'-O-methyl-stabilized ribozyme after uptake by DOTAP transfection or asfree ribozyme. A study by capillary electrophoresis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes

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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Phosphorothiolate ribozyme against the conserved sequence in V3 loop of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Cellular uptake properties of a 2'-amino/2'-O-methyl-modified chimeric hammerhead ribozyme targeted to the epidermal growth factor receptor mRNA.

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7 January 2021

Numbering system for the hammerhead

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7 January 2021

Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

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https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Cellular uptake and intracellular fate of antisense oligonucleotides

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7 January 2021

Characterization of oligonucleotide transport into living cells

1 reference

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7 January 2021

Studies on uptake, sub-cellular trafficking and efflux of antisense oligodeoxynucleotides in glioma cells using self-assembling cationic lipoplexes as delivery systems.

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7 January 2021

Intracellular distribution of microinjected antisense oligonucleotides

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7 January 2021

Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides

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7 January 2021

Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth

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7 January 2021

Lipid-based systems for the intracellular delivery of genetic drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

In vitro transport and delivery of antisense oligonucleotides

1 reference

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7 January 2021

Preparation and application of liposome-incorporated oligodeoxynucleotides

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7 January 2021

Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells

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7 January 2021

Use of a hammerhead ribozyme with cationic liposomes to reduce leukocyte type 12-lipoxygenase expression in vascular smooth muscle

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7 January 2021

Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity

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7 January 2021

Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids

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7 January 2021

Cell-specific optimization of phosphorothioate antisense oligodeoxynucleotide delivery by cationic lipids

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7 January 2021

Toxicity of cationic lipid-ribozyme complexes in human prostate tumor cells can mimic ribozyme activity

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7 January 2021

Lipoplexes and tumours. A review

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7 January 2021

Uptake of liposomes containing phosphatidylserine by liver cells in vivo and by sinusoidal liver cells in primary culture: in vivo-in vitro differences

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7 January 2021

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

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7 January 2021

pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Novel cationic amphiphiles as delivery agents for antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using starburst PAMAM dendrimers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Enhanced delivery of antisense oligonucleotides with fluorophore-conjugated PAMAM dendrimers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Development of a sustained-release biodegradable polymer delivery system for site-specific delivery of oligonucleotides: characterization of P(LA-GA) copolymer microspheres in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Neurite outgrowth in peripherin-depleted PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Enhanced anti-tumor effects with microencapsulated c-myc antisense oligonucleotide.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Histologic comparison of polylactic and polyglycolic acid sutures

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Ribozymes: structure and mechanism in RNA catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Polyalkylcyanoacrylate nanoparticles as polymeric carriers for antisense oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Adsorption of oligonucleotides onto polyisohexylcyanoacrylate nanoparticles protects them against nucleases and increases their cellular uptake

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Cellular delivery of hammerhead ribozymes conjugated to a transferrin receptor antibody.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Antisense inhibition of silica-induced tumor necrosis factor in alveolar macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Folate-mediated targeting of antisense oligodeoxynucleotides to ovarian cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Scavenger receptor-mediated delivery of antisense mini-exon phosphorothioate oligonucleotide to Leishmania-infected macrophages. Selective and efficient elimination of the parasite

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Gene repair using chimeric RNA/DNA oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

pH-sensitive liposomes for receptor-mediated delivery to chicken hepatoma (LMH) cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

In vivo protein transduction: intracellular delivery of biologically active proteins, compounds and DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

A new peptide vector for efficient delivery of oligonucleotides into mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

In vivo protein transduction: delivery of a biologically active protein into the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Brain as a unique antisense environment

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Antisense technologies have a future fighting neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Transferrin receptor on endothelium of brain capillaries

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Transport of [125I]transferrin through the rat blood-brain barrier

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Complete Inactivation of Target mRNA by Biotinylated Antisense Oligodeoxynucleotide-Avidin Conjugates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

CB1 receptor density and CB1 receptor-mediated functional effects in rat hippocampus are decreased by an intracerebroventricularly administered antisense oligodeoxynucleotide

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Dopamine D3 receptor antisense administration reduces basal c-fos and NGFI-B mRNA levels in the rat forebrain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Critical issues in the antisense inhibition of brain gene expression in vivo: experiences targetting the 5-HT1A receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Penetration of oligonucleotides into mouse organism through mucosa and skin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Interaction of oligonucleotide-conjugates with the dipeptide transporter system in Caco-2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2800%2900326-3

7 January 2021

10.1016/S1359-6446(00)00326-3

Identifiers

DOI

1 reference

31 July 2017

1 reference