(Q34199862)

31 July 2017

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title

NODs: intracellular proteins involved in inflammation and apoptosis (English)

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31 July 2017

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Naohiro Inohara

1

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PubMed ID

12766759

31 July 2017

Gabriel Nuñez

series ordinal

2

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31 July 2017

1 May 2003

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Nature Reviews Immunology

31 July 2017

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31 July 2017

3

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31 July 2017

371-382

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31 July 2017

5

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Plant pathogens and integrated defence responses to infection

31 July 2017

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Toll-like receptors and innate immunity

31 March 2020

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Toll-like receptors: critical proteins linking innate and acquired immunity

31 March 2020

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Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing

31 March 2020

1 reference

The molecular mechanism of programmed cell death in C. elegans

31 March 2020

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Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

31 March 2020

1 reference

PKR; a sentinel kinase for cellular stress

31 March 2020

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A dynamically tuned double-stranded RNA binding mechanism for the activation of antiviral kinase PKR.

31 March 2020

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Invasive Shigella flexneri activates NF-kappa B through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells

31 March 2020

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Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

31 March 2020

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The NOD: a signaling module that regulates apoptosis and host defense against pathogens

31 March 2020

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Nods: a family of cytosolic proteins that regulate the host response to pathogens

31 March 2020

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The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations

31 March 2020

1 reference

The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

31 March 2020

1 reference

WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation

31 March 2020

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Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

31 March 2020

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Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

31 March 2020

1 reference

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation

31 March 2020

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Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

31 March 2020

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A Draft Sequence of the Rice Genome (Oryza sativa L. ssp. japonica)

31 March 2020

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The CARD domain: a new apoptotic signalling motif

31 March 2020

1 reference

The PYRIN domain: a novel motif found in apoptosis and inflammation proteins

31 March 2020

1 reference

The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation

31 March 2020

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The DAPIN family: a novel domain links apoptotic and interferon response proteins

31 March 2020

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PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.

31 March 2020

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Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

31 March 2020

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Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

31 March 2020

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

31 March 2020

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PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

31 March 2020

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Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product

31 March 2020

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Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains

31 March 2020

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Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

31 March 2020

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Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

31 March 2020

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CLAN, a novel human CED-4-like gene

31 March 2020

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Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins

31 March 2020

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A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis

31 March 2020

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

31 March 2020

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PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing

31 March 2020

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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

31 March 2020

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A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development

31 March 2020

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The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

31 March 2020

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Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes

31 March 2020

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Structural basis for the inhibition of caspase-3 by XIAP

31 March 2020

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

31 March 2020

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Structural basis of IAP recognition by Smac/DIABLO

31 March 2020

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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

31 March 2020

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The bare lymphocyte syndrome and the regulation of MHC expression

31 March 2020

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Dendritic cell-specific MHC class II transactivator contains a caspase recruitment domain that confers potent transactivation activity

31 March 2020

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The Arabidopsis RRS1-R disease resistance gene--uncovering the plant's nucleus as the new battlefield of plant defense?

31 March 2020

1 reference

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

31 March 2020

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Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

31 March 2020

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Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

31 March 2020

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Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

31 March 2020

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Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

31 March 2020

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Human Nod1 confers responsiveness to bacterial lipopolysaccharides

31 March 2020

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CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

31 March 2020

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

31 March 2020

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ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis

31 March 2020

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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

31 March 2020

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ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

31 March 2020

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Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1

31 March 2020

1 reference

Two distinct domains within CIITA mediate self-association: involvement of the GTP-binding and leucine-rich repeat domains

31 March 2020

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Self-association of class II transactivator correlates with its intracellular localization and transactivation

31 March 2020

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Self-association of CIITA and its transactivation potential

31 March 2020

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

31 March 2020

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Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

31 March 2020

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

31 March 2020

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

31 March 2020

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Natural adjuvants: endogenous activators of dendritic cells

31 March 2020

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The danger model: a renewed sense of self

31 March 2020

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

31 March 2020

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The apoptotic signaling pathway activated by Toll-like receptor-2

31 March 2020

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Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling

31 March 2020

1 reference

Death receptors: signaling and modulation

31 March 2020

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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

31 March 2020

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

31 March 2020

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NF-kappaB signals induce the expression of c-FLIP.

31 March 2020

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Human macrophage activation programs induced by bacterial pathogens

31 March 2020

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Endotoxin and muramyl dipeptide modulate surface receptor expression on human mononuclear cells

31 March 2020

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Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

31 March 2020

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Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture

31 March 2020

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The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan

31 March 2020

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Interactions between Listeria monocytogenes and host mammalian cells

31 March 2020

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Mutation in the class II trans-activator leading to a mild immunodeficiency

31 March 2020

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

31 March 2020

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Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

31 March 2020

1 reference

CARD15 mutations in Blau syndrome

31 March 2020

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CARD15 mutations in familial granulomatosis syndromes: a study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy.

31 March 2020

1 reference

Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

31 March 2020

1 reference

New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes

31 March 2020

1 reference

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

31 March 2020

1 reference

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

31 March 2020

1 reference

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

31 March 2020

1 reference

Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

31 March 2020

1 reference

A candidate gene for familial Mediterranean fever

31 March 2020

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Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis

31 March 2020

1 reference

Identification and characterization of a spinal muscular atrophy-determining gene

31 March 2020

1 reference

A mouse model for spinal muscular atrophy

31 March 2020

1 reference

Cloning and characterization of the multiple murine homologues of NAIP (neuronal apoptosis inhibitory protein).

31 March 2020

1 reference

Genetic and physical mapping of the mouse host resistance locus Lgn1

31 March 2020

1 reference

The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts.

31 March 2020

1 reference

Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene

31 March 2020

1 reference

Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13

31 March 2020

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Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.

31 March 2020

1 reference

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila.

31 March 2020

1 reference

Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus

31 March 2020

1 reference

The WRKY superfamily of plant transcription factors.

31 March 2020

1 reference

A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta

31 March 2020

1 reference

The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila.

31 March 2020

1 reference

NALPs: a novel protein family involved in inflammation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI1086

1 reference

31 July 2017

1 reference

PubMed ID

12766759