(Q34213703)

English

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

scientific article published on May 1, 1973

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Europe PubMed Central

PubMed publication ID

31 July 2017

Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds (English)

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

0 references

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

author name string

F. Oesch

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A4584115

8 February 2023

publication date

1 May 1973

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Europe PubMed Central

PubMed publication ID

31 July 2017

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full work available at URL

http://www.tandfonline.com/doi/pdf/10.3109/00498257309151525

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

305-340

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

publication type of scholarly work

1 reference

Europe PubMed Central

An enzyme from rat liver catalysing conjugations with glutathione. 2. Replacement of nitro groups

1 reference

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Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol

1 reference

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Studies in detoxication. 51. The determination of catechols in urine, and the formation of catechols in rabbits receiving halogenobenzenes and other compounds; dihydroxylation in vivo

1 reference

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An enzyme from rat liver catalysing conjugations with glutathione

1 reference

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Metabolism of polycyclic compounds. 17. The reaction of 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene with glutathione catalysed by tissue preparations

1 reference

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Metabolism of polycyclic compounds. 18. The secretion of metabolites of naphthalene, 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene in rat bile

1 reference

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Metabolism of polycyclic compounds. 16. The metabolism of 1:2-dihydronaphthalene and 1:2-epoxy-1:2:3:4-tetrahydronaphthalene

1 reference

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METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 9,10-EPOXY-9,10-DIHYDROPHENANTHRENE IN RATS

1 reference

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The metabolism of benz[a]anthracene and dibenz[a,h]anthracene and their 5,6-epoxy-5,6-dihydro derivatives by rat-liver homogenates

1 reference

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The carcinogenic activities in mice of compounds related to benz[a]anthracene

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AN ENZYME CATALYSING THE CONJUGATION OF EPOXIDES WITH GLUTATHIONE

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Possible mechanism of liver necrosis caused by aromatic organic compounds

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EVIDENCE FOR THE BINDING OF POLYNUCLEAR AROMATIC HYDROCARBONS TO THE NUCLEIC ACIDS OF MOUSE SKIN: RELATION BETWEEN CARCINOGENIC POWER OF HYDROCARBONS AND THEIR BINDING TO DEOXYRIBONUCLEIC ACID.

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1 reference

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Cyclodiene epoxide ring hydration by microsomes from mammalian liver and houseflies

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Selective metabolism of cyclodiene insecticide enantiomers by pig liver microsomal enzymes

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Species differences in the inhibition of glutathione S-aryltransferase by phthaleins and dicarboxylic acids

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The role of substrate structure in the initiation of enzymic cyclization of squalene 2,3-oxide. Studies with 2,3-cis-1'-norsqual ene 2,3-oxide and 2,3-trans-1'-norsqualene 2,3-oxide

1 reference

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Arene oxides and the NIH shift: the metabolism, toxicity and carcinogenicity of aromatic compounds.

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Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide

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Studies in detoxication. 73. The metabolism of alkylbenzenes: phenylacetylene and phenylethylene (styrene).

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Metabolism of rotenone in vitro by tissue homogenates from mammals and insects

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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

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Reactivity of the K-region epoxides of some polycyclic hydrocarbons towards the nucleic acids and proteins of BHK 21 cells

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Enzyme-catalysed reactions of polycyclic hydrocarbons with deoxyribonucleic acid and protein in vitro

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In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons

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21 January 2018

Biochemical studies of toxic agents. 13. The metabolism of acenaphthylene

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Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons

1 reference

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Arene Oxides as Intermediates in the Metabolism of Aromatic Substrates: Alkyl and Oxygen Migrations during Isomerization of Alkylated Arene Oxides

1 reference

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Arene oxides as intermediates in the oxidative metabolism of aromatic compounds. Isomerization of methyl-substituted arene oxides

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Determination of the h-protein in transformable and transformed cells in culture

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Binding of K-region epoxides and other derivatives of benz(a)anthracene and dibenz(a,h)anthracene to DNA, RNA, and proteins of transformable cells

1 reference

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Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid

1 reference

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Incorporation of radioactive- -aminolevulinic acid into microsomal cytochrome P 450 : selective breakdown of the hemoprotein by allylisopropylacetamide and carbon tetrachloride

1 reference

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Observations on the metabolism of cis- and trans-indane-1, 2-diols

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The in vivo and in vitro induction of aryl hydrocarbon hydroxylase in mammalian cells of different species, tissues, strains, and developmental and hormonal states

1 reference

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Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes

1 reference

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A reconstituted microsomal enzyme system that converts naphthalene to trans-1,2-dihydroxy-1,2-dihydronaphthalene via naphthalene-1,2-oxide: Presence of epoxide hydrase in cytochrome P-450 and P-448 fractions

1 reference

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Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

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Studies in detoxication. 63. The metabolism of halogenobenzenes. (a) Meta-dichlorobenzene. (b) Further observations on the metabolism of chlorobenzene

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An epoxide is an intermediate in the microsomal metabolism of the chemical carcinogen, dibenz(a,h)anthracene

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The carcinogenic activities in mice of compounds related to 3-methylcholanthrene

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The metabolism of 7- and 12-methylbenz[a]-anthracene and their derivatives

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Studies in detoxication; the metabolism of chlorobenzene in the rabbit; isolation of dihydrodihydroxychlorobenzene, p-chlorophenylglucuronide, 4-chlorocatechol glucuronide and p-chlorophenylmercapturic acid

1 reference

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Benzene Oxide-Oxepin Valence Tautomerism

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EPOXIDATION OF ALDRIN, ISODRIN, AND HEPTACHLOR BY RAT LIVER MICROSOMES.

1 reference

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A novel mechanism for the NIH-shift

1 reference

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Autoxidation of 1,4-dihydronaphthalene. Formation of 3-benzoxepin via pyrolysis of 2-hydroperoxy-1,2-dihydronaphthalene

1 reference

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Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens

2

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Inhibition of microsomal drug metabolism by methylenedioxybenzenes

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Rearrangement of (1- 2 H)- and (2- 2 H)naphthalene 1,2-oxides to 1-naphthol. Mechanism of the NIH shift

10

1 reference

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INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS

30

1 reference

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Cancer Research

31

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author name string

Conney A. H.

publication date

1956

1 reference

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Mutagenicity of epoxides of polycyclic hydrocarbons correlates with carcinogenicity of parent hydrocarbons

32

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Migration of deuterium during aryl hydroxylation. 3. Effect of ortho- and meta- substituents

36

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Enzymic hydration of 8,9-indan oxide. Homoallylic addition of water

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Metabolism and macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h)anthracene by mouse embryo cells in culture

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Species differences in the in vitro metabolism of HEOM: a chlorinated cyclodiene epoxide

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Cancer Research

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Cancer Research

52

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Goshman L. M.

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1967

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Epoxides as microsomal metabolites of polycyclic hydrocarbons

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Formation of K-region epoxides as microsomal metabolites of pyrene and benzo(a)pyrene

55

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Interactions of the K-region epoxides of phenanthrene and dibenz (a,h)anthracene with nucleic acids and histone

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Reactions of ‘K’-region epoxides of polycyclic hydrocarbons with nucleic acids and polyribonucleotides

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8 February 2023

Biochemical Journal

59

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Grover P. L.

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1972

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Quantitative studies on the hydroxylation-induced migration of deuterium and tritium during phenylalanine hydroxylation

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Metabolic products of naphthalene in mammalian systems

65

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The isolation of a complex of heavy meromyosin and adenine nucleotide

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Factors affecting the enzymatic formation of o-methylated dihydroxy derivatives

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The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. II. Synthesis of 3,4-toluene-4-d oxide and subsequent "NIH shift" to 4-hydroxytoluene-3-H

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The role of arene oxide-oxepin systems in the metabolism of aromatic substrates. III. Formation of 1,2-naphthalene oxide from naphthalene by liver microsomes

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1,2-Naphthalene oxide as an intermediate in the microsomal hydroxylation of naphthalene. V

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8 February 2023

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Oxidation of styrene in liver microsomes

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Oxidation of cycloalkenes in liver microsomes

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Destruction of Cytochrome P 450 by Secobarbital and Other Barbiturates Containing Allyl Groups

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Cancer Research

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A microsomal catechol O-methyltransferase from rat liver

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Low Carcinogenicity of the K-Region Epoxides of 7-Methylbenz(a)-anthracene and Benz (a) anthracene in the Mouse and Rat

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8 February 2023

Journal of the American Chemical Society

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8 February 2023

Biochemical Journal

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Oesch F

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1973

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Solubilization, purification, and properties of a hepatic epoxide hydrase

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A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide

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Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: Evidence for homologous enzymes

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Induction, activation and inhibition of epoxide hydrase: an anomalous prevention of chlorobenzene-induced hepatotoxicity by an inhibitor of epoxide hydrase

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The conversion of phenanthrene 9, 10-oxide and dibenz[a, h]anthracene 5, 6-oxide into dihydrodiols by a rat-liver microsomal enzyme

122

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Metabolic studies with deuterated phenobarbital

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8 February 2023

Journal of the Chemical Society

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Schoppee C. W.

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1957

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METABOLISM OF DRUGS AND TOXIC SUBSTANCES.

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METABOLISM OF POLYCYCLIC COMPOUNDS. THE METABOLISM OF 1,4-EPOXY-1,4-DIHYDRONAPHTHALENE IN RATS

132

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The metabolism of benzo[a]pyrene by rat-liver homogenates

135

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Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparations

136

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Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation of benz[a]anthracene 8,9-oxide and 10,11-dihydrobenz[a]anthracene 8,9-oxide and their metabolism by rat liver preparations

137

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Epoxy derivatives of aromatic polycyclic hydrocarbons. The synthesis of dibenz[a,c]anthracene 10,11-oxide and its metabolism by rat liver preparations

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The Preparation of 7-Hydroxymethylbenz[a]anthracene 5,6-Oxide and its Metabolism by Rat-liver Preparations

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5,6-Dihydro-5,6-dihydroxycarbaryl glucuronide as a significant metabolite of carbaryl in the rat

142

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Pharmacologic and metabolic studies with deuterated zoxazolamine

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On the participation of cytochrome P-450 in the formation of 16, 17-dihydroxylated C(19) steroids from 16-dehydro-C(19) steroids

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Stereoselective hydrolysis of acyclic olefin oxides to glycols by hepatic microsomal epoxide hydrolase

154

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Stereoselective hydrolysis of cis- and trans-stilbene oxides by hepatic microsomal epoxide hydrolase

155

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Solubilization of Epoxide Hydrolase from Liver Microsomes

156

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Stereoselective hydrolysis of 2,3-epoxysteroids by hepatic microsomal epoxide hydrolase

157

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Studies on enzymatic hydrolysis of aziridines. I. The conversion of 2 beta,3beta-imino-5 alpha-cholestane into 2 beta-amino-3-alpha-hydroxy-5 alpha-cholestane by liver microsomes

158

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Aryl hydrocarbon (benzo[a]pyrene) hydroxylase in microsomes from rat tissues: Differential inhibition and stimulation by benzoflavones and organic solvents

159

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Comparative response of insects and mammals to certain halogenated hydrocarbons used as insecticides

161

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Metabolism of the herbicide 2,6-dichlorobenzonitrile in rabbits and rats

162

1 reference

10.3109/00498257309151525

https://api.crossref.org/works/10.3109/00498257309151525

8 February 2023

Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity

1 reference

https://opencitations.net/index/api/v1/citations/10.1021/JF60166A048

20 August 2024

Identifiers

10.3109/00498257309151525

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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