(Q34225700)

31 July 2017

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title

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution (English)

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31 July 2017

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2

Christopher M Dobson

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31 July 2017

Massimo Stefani

1

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31 July 2017

27 August 2003

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Journal of Molecular Medicine

31 July 2017

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31 July 2017

81

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31 July 2017

678-699

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31 July 2017

11

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https://scigraph.springernature.com/pub.10.1007/s00109-003-0464-5

31 July 2017

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cites work

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

1 reference

12 December 2020

Proteasomal degradation of tau protein

1 reference

12 December 2020

Channel formation by a neurotoxic prion protein fragment

1 reference

12 December 2020

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1 reference

12 December 2020

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

1 reference

12 December 2020

Protein folding and disease: a view from the first Horizon Symposium.

1 reference

12 December 2020

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

1 reference

12 December 2020

Atherosclerosis: another protein misfolding disease?

1 reference

12 December 2020

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

1 reference

12 December 2020

Folding and aggregation are selectively influenced by the conformational preferences of the alpha-helices of muscle acylphosphatase.

1 reference

12 December 2020

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

12 December 2020

Ultrastructural organization of amyloid fibrils by atomic force microscopy

1 reference

12 December 2020

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

12 December 2020

Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases

1 reference

12 December 2020

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

1 reference

12 December 2020

Globular amyloid deposits in the wall of the gastrointestinal tract: report of six cases.

1 reference

12 December 2020

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

1 reference

12 December 2020

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption

1 reference

12 December 2020

Perforin lytic activity is controlled by calreticulin

1 reference

12 December 2020

Protein and water contents of aging brain.

1 reference

12 December 2020

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1 reference

12 December 2020

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

12 December 2020

Genetic polymorphisms in Parkinson's disease.

1 reference

12 December 2020

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

1 reference

12 December 2020

Immunotherapy for Alzheimer's disease: will vaccination work?

1 reference

12 December 2020

Pore formation by the cytotoxic islet amyloid peptide amylin

1 reference

12 December 2020

Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases

1 reference

12 December 2020

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

12 December 2020

Fresh and globular amyloid beta protein (1-42) induces rapid cellular degeneration: evidence for AbetaP channel-mediated cellular toxicity

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Frequencies of amino acid strings in globular protein sequences indicate suppression of blocks of consecutive hydrophobic residues

1 reference

12 December 2020

Impaired proteasome function in Alzheimer's disease

1 reference

12 December 2020

Role of Escherichia coli curli operons in directing amyloid fiber formation

1 reference

12 December 2020

Extracellular control of cell size

1 reference

12 December 2020

Molecular crowding accelerates fibrillization of alpha-synuclein: could an increase in the cytoplasmic protein concentration induce Parkinson's disease?

1 reference

12 December 2020

Ocular changes in heredo-oto-ophthalmo-encephalopathy

1 reference

12 December 2020

The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded

1 reference

12 December 2020

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

1 reference

12 December 2020

Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin

1 reference

12 December 2020

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

12 December 2020

Alteration of free radical metabolism in the brain of mice infected with scrapie agent.

1 reference

12 December 2020

Interaction of intracellular beta amyloid peptide with chaperone proteins

1 reference

12 December 2020

Cleavage of a C-terminal peptide is essential for heptamerization of Clostridium perfringens epsilon-toxin in the synaptosomal membrane

1 reference

12 December 2020

Chaperone function and chaperone overload in the aged. A preliminary analysis

1 reference

12 December 2020

Channel activity of deamidated isoforms of prion protein fragment 106-126 in planar lipid bilayers

1 reference

12 December 2020

The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.

1 reference

12 December 2020

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

12 December 2020

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

1 reference

12 December 2020

Proteasomal function is impaired in substantia nigra in Parkinson's disease

1 reference

12 December 2020

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

12 December 2020

Protein misfolding, evolution and disease

1 reference

12 December 2020

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

1 reference

12 December 2020

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

1 reference

12 December 2020

The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation

1 reference

12 December 2020

Defective protein folding as a basis of human disease

1 reference

12 December 2020

From computer simulations to human disease: emerging themes in protein folding

1 reference

12 December 2020

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

12 December 2020

Regulation of the complement membrane attack pathway

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12 December 2020

Cholesterol is an important factor affecting the membrane insertion of beta-amyloid peptide (A beta 1-40), which may potentially inhibit the fibril formation

1 reference

12 December 2020

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

1 reference

12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

12 December 2020

De novo designed peptide-based amyloid fibrils

1 reference

12 December 2020

Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".

1 reference

12 December 2020

Kidney dialysis-associated amyloidosis: a molecular role for copper in fiber formation

1 reference

12 December 2020

Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module

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12 December 2020

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

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12 December 2020

Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

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12 December 2020

Retrograde protein translocation: ERADication of secretory proteins in health and disease

1 reference

12 December 2020

The channel hypothesis of Huntington's disease

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12 December 2020

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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12 December 2020

The structural basis of protein folding and its links with human disease

1 reference

12 December 2020

Hsp70 and antifibrillogenic peptides promote degradation and inhibit intracellular aggregation of amyloidogenic light chains

1 reference

12 December 2020

Hsp90 as a capacitor for morphological evolution

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12 December 2020

Neurodegenerative disease: amyloid pores from pathogenic mutations.

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12 December 2020

The 'molten globule' state is involved in the translocation of proteins across membranes?

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12 December 2020

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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12 December 2020

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

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12 December 2020

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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12 December 2020

Chaperoning brain degeneration

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12 December 2020

Inhibition of A beta fibril formation and A beta-induced cytotoxicity by senile plaque-associated proteins

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12 December 2020

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

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12 December 2020

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

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12 December 2020

Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel

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12 December 2020

Induction of heme oxygenase-1 in the brains of scrapie-infected mice

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12 December 2020

Aggresomes and Russell bodies. Symptoms of cellular indigestion?

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12 December 2020

Identification of genes that modify ataxin-1-induced neurodegeneration.

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12 December 2020

Impairment of the ubiquitin-proteasome system by protein aggregation

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12 December 2020

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

12 December 2020

Mouse and fly models of neurodegeneration

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12 December 2020

A one-hit model of cell death in inherited neuronal degenerations

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12 December 2020

Mechanisms of apoptosis

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12 December 2020

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

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12 December 2020

Analysis of aqueous humour proteins of eyes with and without pseudoexfoliation syndrome.

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12 December 2020

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

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12 December 2020

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

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12 December 2020

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

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12 December 2020

Ion channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: the role of dangerous unchaperoned molecules

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12 December 2020

Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain

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12 December 2020

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

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12 December 2020

A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro

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12 December 2020

Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense

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12 December 2020

The ubiquitin protein catabolic disorders.

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12 December 2020

Macromolecular crowding: an important but neglected aspect of the intracellular environment

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12 December 2020

Reduction of the amyloidogenicity of a protein by specific binding of ligands to the native conformation

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12 December 2020

Evidence for oxidative stress in experimental prion disease

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12 December 2020

Sick chaperones and ageing: a perspective

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12 December 2020

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

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12 December 2020

Chaperone overload is a possible contributor to 'civilization diseases'.

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12 December 2020

Genetically determined neuropathies

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12 December 2020

Natively unfolded proteins: a point where biology waits for physics

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12 December 2020

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

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12 December 2020

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

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12 December 2020

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

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12 December 2020

Unfolding retinal dystrophies: a role for molecular chaperones?

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12 December 2020

Effect of amyloid beta-peptide on permeability transition pore: a comparative study.

1 reference

12 December 2020

Amyloid fibril formation by an SH3 domain

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12 December 2020

Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains.

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

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12 December 2020

Macromolecular crowding and its role as intracellular signalling of cell volume regulation

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12 December 2020

Properties of cytotoxic peptide-formed ion channels

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12 December 2020

Impairment of membrane transport and signal transduction systems by amyloidogenic proteins.

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12 December 2020

Speculations on the functions of the major heat shock and glucose-regulated proteins

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12 December 2020

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

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12 December 2020

Molecular chaperones in the cytosol: from nascent chain to folded protein

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12 December 2020

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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12 December 2020

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

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12 December 2020

Pathogenic light chains and the B-cell repertoire

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12 December 2020

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

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12 December 2020

Synthetic mammalian C-type natriuretic peptide forms large cation channels

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12 December 2020

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

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12 December 2020

Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease

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12 December 2020

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

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12 December 2020

Antibacterial agents based on the cyclic D,L-alpha-peptide architecture

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12 December 2020

Thousands of proteins likely to have long disordered regions.

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12 December 2020

High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation

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12 December 2020

Membrane insertion of the heptameric staphylococcal alpha-toxin pore. A domino-like structural transition that is allosterically modulated by the target cell membrane

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12 December 2020

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12 December 2020

FlgM gains structure in living cells

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12 December 2020

Transmissible and genetic prion diseases share a common pathway of neurodegeneration

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12 December 2020

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

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12 December 2020

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

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12 December 2020

Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis

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12 December 2020

Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells

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12 December 2020

The protofilament structure of insulin amyloid fibrils

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12 December 2020

Abeta25-35 induces rapid lysis of red blood cells: contrast with Abeta1-42 and examination of underlying mechanisms

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12 December 2020

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

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12 December 2020

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

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12 December 2020

Detection of two partially structured species in the folding process of the amyloidogenic protein beta 2-microglobulin

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12 December 2020

Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

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12 December 2020

Crystal structure of monomeric human -2-microglobulin reveals clues to its amyloidogenic properties

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12 December 2020

Ideas of order for amyloid fibril structure

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12 December 2020

The major substrates for TAP in vivo are derived from newly synthesized proteins

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12 December 2020

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease.

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12 December 2020

Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing

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12 December 2020

Natural hyperthermia and expression of the heat shock protein Hsp70 affect developmental abnormalities in Drosophila melanogaster.

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12 December 2020

Cell cycle. Order from destruction

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12 December 2020

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90.

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12 December 2020

Fresh and nonfibrillar amyloid beta protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AbetaP-channel-mediated cellular toxicity

1 reference

12 December 2020

alpha-Synuclein implicated in Parkinson's disease catalyses the formation of hydrogen peroxide in vitro.

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

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12 December 2020

Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro

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12 December 2020

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes.

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12 December 2020

Oxidative stress and the prion protein in transmissible spongiform encephalopathies

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Poly-L-glutamine forms cation channels: relevance to the pathogenesis of the polyglutamine diseases

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12 December 2020

Hsp90 as a capacitor of phenotypic variation

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12 December 2020

Alzheimer's amyloid fibrils: structure and assembly

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12 December 2020

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

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12 December 2020

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

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12 December 2020

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

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12 December 2020

Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques.

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12 December 2020

Altered aggregation properties of mutant gamma-crystallins cause inherited cataract

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12 December 2020

Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam

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12 December 2020

Refolding of recombinant proteins

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12 December 2020

Oxidative stress and protein aggregation during biological aging

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12 December 2020

The protofilament substructure of amyloid fibrils11Edited by F. E. Cohen

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12 December 2020

Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

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12 December 2020

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

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12 December 2020

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

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12 December 2020

Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

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12 December 2020

Charge attraction and beta propensity are necessary for amyloid fibril formation from tetrapeptides

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12 December 2020

Nature disfavors sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis

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12 December 2020

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12 December 2020

The radical model of Alzheimer's disease: specific recognition of Gly29 and Gly33 by Met35 in a beta-sheet model of Abeta: an ONIOM study.

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12 December 2020

Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

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12 December 2020

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

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12 December 2020

Amyloid-like protein structure in mammalian ocular lenses.

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12 December 2020

The molecular chaperone concept

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12 December 2020

In vitro unfolding, refolding, and polymerization of human gammaD crystallin, a protein involved in cataract formation

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12 December 2020

10.1007/S00109-003-0464-5

Identifiers

DOI

1 reference

PubMed ID

12942175

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

12942175