(Q34235311)

31 July 2017

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title

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein (English)

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31 July 2017

Zhang Y

1

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PubMed ID

11327196

31 July 2017

Benet LZ

series ordinal

2

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31 July 2017

1 January 2001

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Clinical Pharmacokinetics

31 July 2017

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31 July 2017

40

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31 July 2017

159-168

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31 July 2017

3

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https://scigraph.springernature.com/pub.10.2165/00003088-200140030-00002

31 July 2017

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12 December 2020

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Effect of intestinal P-glycoprotein on daily tacrolimus trough level in a living-donor small bowel recipient

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12 December 2020

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12 December 2020

Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell.

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12 December 2020

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine

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12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

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12 December 2020

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine

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12 December 2020

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12 December 2020

The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain

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12 December 2020

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

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12 December 2020

Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes

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12 December 2020

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

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12 December 2020

The immunocytochemical localisation and distribution of cytochrome P-450 in normal human hepatic and extrahepatic tissues with a monoclonal antibody to human cytochrome P-450

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12 December 2020

Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers

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12 December 2020

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12 December 2020

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12 December 2020

First-pass metabolism of cyclosporin by the gut

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12 December 2020

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12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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12 December 2020

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12 December 2020

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12 December 2020

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

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12 December 2020

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12 December 2020

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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12 December 2020

Effect of saquinavir on the pharmacokinetics and pharmacodynamics of oral and intravenous midazolam.

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12 December 2020

Excretion and metabolism of 14C-midazolam in humans following oral dosing.

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12 December 2020

Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.

1 reference

12 December 2020

Grapefruit juice-drug interactions

1 reference

12 December 2020

Pharmacokinetic interactions between HIV-protease inhibitors in rats

1 reference

12 December 2020

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

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12 December 2020

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

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12 December 2020

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12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Cloning and functional expression of a human liver organic cation transporter

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12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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12 December 2020

Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A

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12 December 2020

Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

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12 December 2020

The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin.

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12 December 2020

Substrates of human hepatic cytochrome P450 3A4.

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12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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12 December 2020

10.2165/00003088-200140030-00002

Identifiers

DOI

1 reference

PubMed ID

11327196

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11327196