(Q34236127)

31 July 2017

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title

Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease (English)

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31 July 2017

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1

Semenza GL

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PubMed ID

11328942

31 July 2017

language of work or name

English

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publication date

1 May 2001

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31 July 2017

1 reference

31 July 2017

49

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31 July 2017

614-617

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31 July 2017

5

1 reference

https://scigraph.springernature.com/pub.10.1203/00006450-200105000-00002

31 July 2017

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cites work

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Purification and characterization of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Age-dependent impairment of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

In vivo evidence that erythropoietin protects neurons from ischemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Differential effects of adenosine receptor subtypes on release and reuptake of hippocampal serotonin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Expression of hypoxia-inducible factor 1? in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Characterization of the alpha1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

ERK activation upon hypoxia: involvement in HIF-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

21 January 2018

1 reference

https://api.crossref.org/works/10.1203%2F00006450-200105000-00002

Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Induction of the Plasminogen Activator Inhibitor-1 Gene Expression by Mild Hypoxia Via a Hypoxia Response Element Binding the Hypoxia-Inducible Factor-1 in Rat Hepatocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

The function of hypoxia-inducible factor 1 (HIF-1) is impaired in senescent mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Mersalyl is a novel inducer of vascular endothelial growth factor gene expression and hypoxia-inducible factor 1 activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Identification of a hypoxia response element in the transferrin receptor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1203/00006450-200105000-00002

Identifiers

DOI

10.1203/00006450-200105000-00002

1 reference

PubMed ID

11328942

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11328942