(Q34267418)

English

Target discovery

scientific article published on October 1, 2003

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

Target discovery (English)

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Europe PubMed Central

1 August 2017

small interfering RNA

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526386

17 March 2024

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526386

17 March 2024

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526386

17 March 2024

1 reference

10.1038/NRD1202

https://api.crossref.org/works/10.1038/NRD1202

17 March 2024

author name string

Mark A. Lindsay

1

0000-0003-4807-5506

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14526386

17 March 2024

language of work or name

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14526386

17 March 2024

publication date

1 October 2003

1 reference

Europe PubMed Central

1 August 2017

full work available at URL

http://www.nature.com/articles/nrd1202.pdf

Portable Document Format

1 reference

10.1038/NRD1202

https://api.crossref.org/works/10.1038/NRD1202

17 March 2024

http://www.nature.com/articles/nrd1202

1 reference

10.1038/NRD1202

https://api.crossref.org/works/10.1038/NRD1202

17 March 2024

Nature Reviews Drug Discovery

1 reference

Europe PubMed Central

1 August 2017

2

1 reference

Europe PubMed Central

1 August 2017

831-838

1 reference

Europe PubMed Central

1 August 2017

10

1 reference

Europe PubMed Central

1 August 2017

https://scigraph.springernature.com/pub.10.1038/nrd1202

0 references

A guide to drug discovery: Target selection in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

The druggable genome

1 reference

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31 March 2020

Systems biology: a brief overview

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Effects of beta2-agonists on airway tone and bronchial responsiveness

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A Growing Network of Cancer-Susceptibility Genes

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The genetics and genomics of cancer

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Mortality in relation to smoking: 40 years' observations on male British doctors

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Inflammation and cancer

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31 March 2020

Inflammation in atherosclerosis

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31 March 2020

Inflammation and therapeutic vaccination in CNS diseases

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Eat to live, not live to eat.

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Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

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Better therapeutics through microarrays

1 reference

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31 March 2020

The use and analysis of microarray data

1 reference

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31 March 2020

Extracting functional information from microarrays: a challenge for functional genomics

1 reference

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31 March 2020

From patterns to pathways: gene expression data analysis comes of age.

1 reference

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31 March 2020

Protein analysis on a proteomic scale

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Mass spectrometry-based proteomics

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Protein microarray technology

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Is proteomics heading in the wrong direction?

1 reference

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31 March 2020

Huntingtin in health and disease

1 reference

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31 March 2020

Pharmacological strategies for muscular dystrophy

1 reference

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31 March 2020

Cystic fibrosis

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31 March 2020

Molecular medicine. The cholesterol quartet

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31 March 2020

Candidate-gene approaches for studying complex genetic traits: practical considerations

1 reference

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31 March 2020

The design, execution, and interpretation of genetic association studies to decipher complex diseases.

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

A comprehensive review of genetic association studies

1 reference

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31 March 2020

Forward chemical genetics: progress and obstacles on the path to a new pharmacopoeia

1 reference

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31 March 2020

The use of retroviruses as pharmaceutical tools for target discovery and validation in the field of functional genomics

1 reference

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31 March 2020

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

1 reference

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31 March 2020

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse

1 reference

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31 March 2020

Using model-system genetics for drug-based target discovery

1 reference

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31 March 2020

In vivo drug target discovery: identifying the best targets from the genome

1 reference

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31 March 2020

Phage display of antibody fragments.

1 reference

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31 March 2020

Random peptide libraries: a source of specific protein binding molecules

1 reference

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31 March 2020

Aptamers as tools for target prioritization and lead identification

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Novel antisense and peptide nucleic acid strategies for controlling gene expression

1 reference

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31 March 2020

LNA: a versatile tool for therapeutics and genomics

1 reference

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31 March 2020

Hammerhead ribozymes for target validation

1 reference

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31 March 2020

Designed transcription factors as tools for therapeutics and functional genomics

1 reference

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31 March 2020

Functional genomics and target validation approaches using antisense oligonucleotide technology

1 reference

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31 March 2020

RNAi: gene-silencing in therapeutic intervention

1 reference

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31 March 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

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31 March 2020

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

1 reference

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31 March 2020

Gene silencing by adenovirus-delivered siRNA.

1 reference

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31 March 2020

Expression profiling reveals off-target gene regulation by RNAi

1 reference

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31 March 2020

Non-viral gene delivery systems

1 reference

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31 March 2020

Prospects for cationic polymers in gene and oligonucleotide therapy against cancer

1 reference

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31 March 2020

Protein transduction technology

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Peptide-mediated cell delivery: application in protein target validation

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Protein transduction domains: are they delivering?

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Lentiviral-mediated RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FNRD1202

31 March 2020

Targeted adenoviral vectors

1 reference

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31 March 2020

Lentiviral vectors for gene delivery into cells

1 reference

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31 March 2020

Gene delivery using herpes simplex virus vectors

1 reference

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31 March 2020

Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research

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Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

1 reference

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31 March 2020

Full-speed mammalian genetics: in vivo target validation in the drug discovery process

1 reference

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31 March 2020

Knockouts model the 100 best-selling drugs--will they model the next 100?

1 reference

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Transgenic systems in drug discovery: from target identification to humanized mice

1 reference

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C3H apoE(-/-) mice have less atherosclerosis than C57BL apoE(-/-) mice despite having a more atherogenic serum lipid profile

1 reference

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Analysis of gene function in somatic mammalian cells using small interfering RNAs

1 reference

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31 March 2020

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

1 reference

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31 March 2020

Identifiers

10.1038/NRD1202

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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