(Q34293102)

1 August 2017

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title

Apoptosis-regulating proteins as targets for drug discovery (English)

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1 August 2017

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Reed JC

1

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1 August 2017

publication date

1 July 2001

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Trends in Molecular Medicine

1 August 2017

published in

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1 August 2017

volume

7

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1 August 2017

issue

7

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1 August 2017

page(s)

314-319

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1 August 2017

cites work

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Cytochrome c: can't live with it--can't live without it.

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Mitochondria and apoptosis

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

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Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

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7 January 2021

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Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

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Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

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Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

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7 January 2021

Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity

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Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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7 January 2021

The CARD domain: a new apoptotic signalling motif

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7 January 2021

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation

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7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

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7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

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7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

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7 January 2021

ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4.

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7 January 2021

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

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7 January 2021

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

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7 January 2021

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

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7 January 2021

Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death

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7 January 2021

IAP family proteins--suppressors of apoptosis

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7 January 2021

An exegesis of IAPs: salvation and surprises from BIR motifs

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7 January 2021

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

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7 January 2021

An emerging blueprint for apoptosis in Drosophila

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7 January 2021

Mechanisms of apoptosis

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7 January 2021

The Bcl-2 protein family: arbiters of cell survival

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7 January 2021

Mitochondrial control of cell death

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7 January 2021

Bcl-2 family proteins as ion-channels

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7 January 2021

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

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7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

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7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

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7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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7 January 2021

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Apoptosis control by death and decoy receptors

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Promise and problems of Bcl-2 antisense therapy

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

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7 January 2021

10.1016/S1471-4914(01)02026-3

Identifiers

DOI

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1 August 2017

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