(Q34310777)

1 August 2017

Compensatory mutations restore fitness during the evolution of dihydrofolate reductase (English)

1 reference

1 August 2017

6

Daniel L Hartl

1 reference

1 August 2017

Kyle M Brown

1

1 reference

1 August 2017

Marna S Costanzo

2

1 reference

1 August 2017

Wenxin Xu

3

1 reference

1 August 2017

Scott Roy

4

1 reference

1 August 2017

Elena R Lozovsky

5

1 reference

1 August 2017

24 June 2010

1 reference

Molecular Biology and Evolution

1 August 2017

1 reference

1 August 2017

27

1 reference

1 August 2017

2682-2690

1 reference

1 August 2017

12

1 reference

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Adaptive copy number evolution in malaria parasites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Advances in understanding the genetic basis of antimalarial drug resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in Melanesia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Enzyme promiscuity: evolutionary and mechanistic aspects.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

The biological cost of mutational antibiotic resistance: any practical conclusions?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Darwinian evolution can follow only very few mutational paths to fitter proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

The 'evolvability' of promiscuous protein functions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Insights into antifolate resistance from malarial DHFR-TS structures

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Novel approaches to tackling malarial drug resistance using yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Novel antifolate resistant mutations of Plasmodium falciparum dihydrofolate reductase selected in Escherichia coli

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Humans as the world's greatest evolutionary force

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

HIV-1 evolution under pressure of protease inhibitors: climbing the stairs of viral fitness

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Virulence of antibiotic-resistant Salmonella typhimurium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Disruption of the GTP-cyclohydrolase I gene in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Point mutations in Staphylococcus aureus PBP 2 gene affect penicillin-binding kinetics and are associated with resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Limits of adaptation: the evolution of selective neutrality

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Nucleotide sequences of the pbpX genes encoding the penicillin-binding proteins 2x from Streptococcus pneumoniae R6 and a cefotaxime-resistant mutant, C506.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

The evolutionary role of secondary metabolites--a review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

Identification of the optimal third generation antifolate against P. falciparum and P. vivax

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSQ160

Transcriptional analysis of genes encoding enzymes of the folate pathway in the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FMOLBEV%2FMSQ160

Compensatory adaptation to the deleterious effect of antibiotic resistance in Salmonella typhimurium

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2981517

The population genetics of adaptation: the adaptation of DNA sequences

28 October 2018

1 reference

12 December 2020

In search of the limits of evolution

1 reference

12 December 2020

Mutational reversions during adaptive protein evolution

1 reference

12 December 2020

Molecular Evolution Over the Mutational Landscape

1 reference

12 December 2020

Yeast as a model system to study drugs effective against apicomplexan proteins

1 reference

12 December 2020

Identifiers

DOI

10.1093/MOLBEV/MSQ160

1 reference

1 August 2017

1 reference

1 August 2017

1 reference