(Q34318036)

1 August 2017

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title

Chemical genetic approaches for the elucidation of signaling pathways (English)

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1 August 2017

Alaimo PJ

1

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PubMed ID

11470597

1 August 2017

Shogren-Knaak MA

series ordinal

2

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PubMed ID

11470597

1 August 2017

Shokat KM

series ordinal

3

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1 August 2017

1 August 2001

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Current Opinion in Chemical Biology

1 August 2017

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1 August 2017

5

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1 August 2017

360-367

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1 August 2017

4

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Chemical genetics: ligand-based discovery of gene function

1 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Frontiers in chemical genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Design, Synthesis, and Evaluation of Small-Molecule Libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Synthesis and Applications of Small Molecule Libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Diversity-Based Organic Synthesis in the Era of Genomics and Proteomics NRC publication no. 43843. David Thomas is a senior colleague and mentor.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for [...]

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Synthesis of a 10,000 member 1,5-benzodiazepine-2-one library by the directed sorting method

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Construction of a family of biphenyl combinatorial libraries: structure-activity studies utilizing libraries of mixtures

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Combinatorial synthesis and screening of a chemical library of 1,4-dihydropyridine calcium channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Target-oriented and diversity-oriented organic synthesis in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Combinatorial target-guided ligand assembly: identification of potent subtype-selective c-Src inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Site-directed ligand discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Small molecule developmental screens reveal the logic and timing of vertebrate development

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Progress and variations in two-hybrid and three-hybrid technologies

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

In Vivo Protein-Protein Interaction Assays: Beyond Proteins We would like to thank Tony Siu, Dr. Charles Cho, and the members of our lab for their helpful comments as we were preparing this manuscript

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Display cloning: functional identification of natural product receptors using cDNA-phage display

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Corrigendum to: "Display cloning: functional identification of natural product receptors using cDNA-phage display" [Chemistry & Biology 6 (1999) 707-716].

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Protein microarrays: prospects and problems

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Identification of CRE1 as a cytokinin receptor from Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Unnatural ligands for engineered proteins: new tools for chemical genetics

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Elongation factor Tu D138N, a mutant with modified substrate specificity, as a tool to study energy consumption in protein biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Controlling signal transduction with synthetic ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Design of allele-specific inhibitors to probe protein kinase signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Acquisition of inhibitor-sensitive protein kinases through protein design

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Signaling--2000 and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Crystal structure of the Src family tyrosine kinase Hck

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

A chemical switch for inhibitor-sensitive alleles of any protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Controlling signaling with a specifically designed Gi-coupled receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1367-5931%2800%2900215-5

7 January 2021

10.1016/S1367-5931(00)00215-5

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

11470597