(Q34344862)

1 August 2017

1 reference

title

Biochemical mechanisms of drug action: what does it take for success? (English)

1 reference

1 August 2017

David C Swinney

1

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1 August 2017

1 September 2004

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

3

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1 August 2017

801-808

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1 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrd1500

1 August 2017

0 references

1 reference

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

Evidence for acid-induced transformation of omeprazole into an active inhibitor of (H+ + K+)-ATPase within the parietal cell

21 January 2018

1 reference

The pharmacology of the gastric acid pump: the H+,K+ ATPase

21 January 2018

1 reference

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

21 January 2018

1 reference

Evaluation of inhibition of the carbenicillin-hydrolyzing beta-lactamase PSE-4 by the clinically used mechanism-based inhibitors.

21 January 2018

1 reference

Novel mechanisms of action of three antiepileptic drugs, vigabatrin, tiagabine, and topiramate

21 January 2018

1 reference

Characterization of celecoxib and valdecoxib binding to cyclooxygenase.

21 January 2018

1 reference

Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine

21 January 2018

1 reference

The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation

21 January 2018

1 reference

New insights in insurmountable antagonism

21 January 2018

1 reference

Tight binding of the angiotensin AT(1) receptor antagonist

21 January 2018

1 reference

In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist

21 January 2018

1 reference

Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor

21 January 2018

1 reference

Binding of ligands and activation of transcription by nuclear receptors.

21 January 2018

1 reference

The Molecular Pharmacology of SERMs

21 January 2018

1 reference

Antagonism in the human mineralocorticoid receptor.

21 January 2018

1 reference

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

21 January 2018

1 reference

Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease

21 January 2018

1 reference

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

21 January 2018

1 reference

Kinetic discrimination in T-cell activation

21 January 2018

1 reference

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

21 January 2018

1 reference

Kinetic stability as a mechanism for protease longevity

21 January 2018

1 reference

Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays

21 January 2018

1 reference

Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype

21 January 2018

1 reference

Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277

21 January 2018

1 reference

Pharmacology of competitive inhibitors of HMG-CoA reductase.

21 January 2018

1 reference

Tolterodine--a new bladder selective muscarinic receptor antagonist: preclinical pharmacological and clinical data

21 January 2018

1 reference

Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens

21 January 2018

1 reference

Aldosterone antagonists destabilize the mineralocorticosteroid receptor

21 January 2018

1 reference

Progesterone receptor and the mechanism of action of progesterone antagonists

21 January 2018

1 reference

The preclinical pharmacology of ICI 204,219. A peptide leukotriene antagonist

21 January 2018

1 reference

Enzyme inhibition in open systems. Superiority of uncompetitive agents

21 January 2018

1 reference

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein

31 March 2020

1 reference

Aromatase inhibitors and the treatment of breast cancer

31 March 2020

1 reference

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

31 March 2020

1 reference

Importance of the regulation of nuclear receptor degradation

31 March 2020

1 reference

Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex.

31 March 2020

1 reference

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

31 March 2020

1 reference

Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study

31 March 2020

1 reference

A kinetic basis for T cell receptor repertoire selection during an immune response

31 March 2020

1 reference

Inhibitory mechanism of serpins. Interaction of thrombin with antithrombin and protease nexin 1

31 March 2020

1 reference

Action of AT1 receptor antagonists on angiotensin II-induced tone in human isolated subcutaneous resistance arteries

31 March 2020

1 reference

A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists

31 March 2020

1 reference

Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone

31 March 2020

1 reference

Carboxylic acid analogues of tamoxifen: (Z)-2-[p-(1, 2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells

31 March 2020

1 reference

Granisetron: relating pharmacology to clinical efficacy

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1500

1 reference

1 August 2017

1 reference

PubMed ID

15340390