(Q34347507)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

title

Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1

1 reference

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22 October 2019

author name string

K K Nielsen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

K Brøsen

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

language of work or name

English

0 references

publication date

1 April 1995

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Clinical Pharmacology

22 October 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

volume

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

page(s)

433-439

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study

22 October 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Sparteine metabolism in Canadian Caucasians

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Imipramine metabolism: pH-dependent distribution and urinary excretion.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Metabolism of tricyclic antidepressants. A review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Sparteine oxidation polymorphism in Denmark.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Hydroxylation of desmethylimipramine: dependence on the debrisoquin hydroxylation phenotype

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Polymorphic drug oxidation: pharmacokinetic basis and comparison of experimental indices

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

Inhibitors of imipramine metabolism by human liver microsomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1365132

The debrisoquine hydroxylation test predicts steady-state plasma levels of desipramine

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04473.X

CYP2D6 genotype determination in the Danish population.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04473.X

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1365-2125.1995.TB04473.X

Imipramine metabolism in man. A study of urinary metabolites after administration of radioactive imipramine

21 January 2018

1 reference

12 December 2020

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1 reference

12 December 2020

Quinidine inhibits the 2-hydroxylation of imipramine and desipramine but not the demethylation of imipramine

1 reference

12 December 2020

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1 reference

12 December 2020

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1 reference

12 December 2020

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1 reference

12 December 2020

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1 reference

12 December 2020

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1 reference

12 December 2020

High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine

1 reference

12 December 2020

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1 reference

12 December 2020

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver

1 reference

12 December 2020

Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene

1 reference

12 December 2020

Metabolism of imipramine in vitro by isozyme CYP2D6 expressed in a human cell line, and observations on metabolite stability

1 reference

12 December 2020

Polymorphic 2-hydroxylation of desipramine. A population and family study

1 reference

12 December 2020

Isolation and characterization of human liver cytochrome P450 2C19: correlation between 2C19 and S-mephenytoin 4'-hydroxylation

1 reference

12 December 2020

Steady-state kinetics of imipramine in patients

1 reference

12 December 2020

Imipramine metabolites in blood of patients during therapy and after overdose

1 reference

12 December 2020

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1 reference

12 December 2020

Imipramine demethylation and hydroxylation: impact of the sparteine oxidation phenotype

1 reference

12 December 2020

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1 reference

12 December 2020

First-pass metabolism of imipramine and desipramine: Impact of the sparteine oxidation phenotype

1 reference

12 December 2020

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1 reference

12 December 2020

10.1111/J.1365-2125.1995.TB04473.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7640151%20AND%20SRC:MED&resulttype=core&format=json

22 October 2019

1 reference