(Q34380413)

1 August 2017

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title

Dysregulation of the TSC-mTOR pathway in human disease (English)

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1 August 2017

Ken Inoki

1

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1 August 2017

Michael N Corradetti

series ordinal

2

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1 August 2017

Kun-Liang Guan

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 January 2005

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1 August 2017

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1 August 2017

37

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1 August 2017

19-24

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1 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/ng1494

1 August 2017

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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Akt regulates growth by directly phosphorylating Tsc2

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

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Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes

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7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

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7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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7 January 2021

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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7 January 2021

Rapamycin attenuates load-induced cardiac hypertrophy in mice

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7 January 2021

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/NG1494

1 reference

1 August 2017

1 reference