(Q34389488)

1 August 2017

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title

Conditional control of gene expression in the mouse (English)

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1 August 2017

Lewandoski M

1

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1 August 2017

1 October 2001

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1 August 2017

Nature Reviews Genetics

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1 August 2017

2

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1 August 2017

743-755

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1 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/35093537

1 August 2017

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Inducible vectors for expression in mammalian cells

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7 January 2021

Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice

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7 January 2021

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The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice

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Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice

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Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system

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Transactivation of Hox gene expression in a VP16-dependent binary transgenic mouse system.

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A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

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Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential

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Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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Transcriptional activation by tetracyclines in mammalian cells

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Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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7 January 2021

Long-term, noninvasive imaging of regulated gene expression in living mice

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7 January 2021

Conditional lineage ablation to model human diseases

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7 January 2021

The temporal requirement for endothelin receptor-B signalling during neural crest development

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7 January 2021

Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

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7 January 2021

Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.

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7 January 2021

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen

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7 January 2021

Essential role for oncogenic Ras in tumour maintenance

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7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

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7 January 2021

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

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7 January 2021

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

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7 January 2021

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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7 January 2021

Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch

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7 January 2021

Co-regulation of two gene activities by tetracycline via a bidirectional promoter.

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7 January 2021

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

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7 January 2021

Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes

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7 January 2021

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

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7 January 2021

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

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7 January 2021

Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.

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7 January 2021

Ligand-inducible and liver-specific target gene expression in transgenic mice

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7 January 2021

Inducible gene knockouts in the small intestinal and colonic epithelium

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7 January 2021

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

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7 January 2021

Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome

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7 January 2021

Recombinase-mediated gene activation and site-specific integration in mammalian cells

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7 January 2021

Improved properties of FLP recombinase evolved by cycling mutagenesis.

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7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

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7 January 2021

Nuclear targeting determinants of the phage P1 cre DNA recombinase

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7 January 2021

Mammalian genomes contain active recombinase recognition sites

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7 January 2021

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

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7 January 2021

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

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7 January 2021

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

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7 January 2021

Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line

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7 January 2021

Recycling selectable markers in mouse embryonic stem cells

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7 January 2021

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

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7 January 2021

Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

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7 January 2021

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

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7 January 2021

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes

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7 January 2021

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

7 January 2021

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

7 January 2021

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1 reference

7 January 2021

Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles.

1 reference

7 January 2021

Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches

1 reference

7 January 2021

Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene.

1 reference

7 January 2021

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos

1 reference

7 January 2021

Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo

1 reference

7 January 2021

Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH

1 reference

7 January 2021

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch

1 reference

7 January 2021

Fgf8 signalling from the AER is essential for normal limb development.

1 reference

7 January 2021

Fgf8 is required for outgrowth and patterning of the limbs

1 reference

7 January 2021

Generalized lacZ expression with the ROSA26 Cre reporter strain

1 reference

7 January 2021

Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice

1 reference

7 January 2021

Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain

1 reference

7 January 2021

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

1 reference

7 January 2021

Z/AP, a double reporter for cre-mediated recombination.

1 reference

7 January 2021

A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

1 reference

7 January 2021

Fate mapping of the mouse midbrain-hindbrain constriction using a site-specific recombination system

1 reference

7 January 2021

Modelling T-cell memory by genetic marking of memory T cells in vivo

1 reference

7 January 2021

Targeted oncogene activation by site-specific recombination in transgenic mice

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7 January 2021

Muscle-specific cell ablation conditional upon Cre-mediated DNA recombination in transgenic mice leads to massive spinal and cranial motoneuron loss

1 reference

7 January 2021

Cre-mediated chromosome loss in mice

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7 January 2021

Repeat-induced gene silencing in mammals.

1 reference

7 January 2021

Targeted expression of a toxin gene to D1 dopamine receptor neurons by cre-mediated site-specific recombination.

1 reference

7 January 2021

Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification

1 reference

7 January 2021

A method for the generation of conditional gene repair mutations in mice

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7 January 2021

Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders

1 reference

7 January 2021

An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy

1 reference

7 January 2021

Inducible gene targeting in mice

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7 January 2021

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

1 reference

7 January 2021

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

1 reference

7 January 2021

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

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7 January 2021

Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo

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7 January 2021

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

1 reference

7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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7 January 2021

Inducible site-specific recombination in the brain.

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7 January 2021

Regulation of Cre recombinase activity by the synthetic steroid RU 486.

1 reference

7 January 2021

Ligand-activated site-specific recombination in mice

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7 January 2021

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

1 reference

7 January 2021

Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

1 reference

7 January 2021

Temporally and spatially regulated somatic mutagenesis in mice

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7 January 2021

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

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7 January 2021

Inducible site-directed recombination in mouse embryonic stem cells

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7 January 2021

Site- and time-specific gene targeting in the mouse

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7 January 2021

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin

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7 January 2021

Induction of the antigen receptor expression on B lymphocytes results in rapid competence for signaling of SLP-65 and Syk.

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7 January 2021

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

1 reference

7 January 2021

New variants of inducible Cre recombinase: a novel mutant of Cre-PR fusion protein exhibits enhanced sensitivity and an expanded range of inducibility

1 reference

7 January 2021

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

1 reference

7 January 2021

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

1 reference

7 January 2021

Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice

1 reference

7 January 2021

Ubiquitous postnatal LoxP recombination using a doxycycline auto-inducible Cre transgene (DAI-Cre)

1 reference

7 January 2021

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

1 reference

7 January 2021

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

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7 January 2021

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

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7 January 2021

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

1 reference

7 January 2021

Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase

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7 January 2021

High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.

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7 January 2021

Gene-experience interaction alters the cholinergic septohippocampal pathway of mice

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7 January 2021

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

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7 January 2021

Disruption of the c/ebp alpha gene in adult mouse liver

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7 January 2021

Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion

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7 January 2021

FLP-mediated site-specific recombination in microinjected murine zygotes

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7 January 2021

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

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7 January 2021

Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination

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7 January 2021

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

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7 January 2021

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

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7 January 2021

Ligand-regulated site-specific recombination

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7 January 2021

Widespread recombinase expression using FLPeR (flipper) mice

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7 January 2021

Origin of the precerebellar system.

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7 January 2021

Pax6 is required for the multipotent state of retinal progenitor cells

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7 January 2021

Identification of ligands and coligands for the ecdysone-regulated gene switch

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7 January 2021

The lac operator-repressor system is functional in the mouse

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7 January 2021

New insights into host factor requirements for prokaryotic beta-recombinase-mediated reactions in mammalian cells

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7 January 2021

Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase

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7 January 2021

Chimeras of the Flp and Cre recombinases: tests of the mode of cleavage by Flp and Cre

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7 January 2021

Cre mutants with altered DNA binding properties

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7 January 2021

Creating conditional mutations in mammals

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7 January 2021

Small molecule developmental screens reveal the logic and timing of vertebrate development

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7 January 2021

Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator

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7 January 2021

Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism

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7 January 2021

A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3.

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7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

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7 January 2021

Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

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7 January 2021

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

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7 January 2021

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

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7 January 2021

Identifiers

DOI

10.1038/35093537

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PubMed ID

11584291

Dimensions Publication ID

1 August 2017

0 references

1 reference

PubMed ID

11584291