(Q34405471)

2 August 2017

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title

The role of E2A-PBX1 in leukemogenesis (English)

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2 August 2017

Aspland SE

1

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2 August 2017

Bendall HH

series ordinal

2

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2 August 2017

Murre C

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 September 2001

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2 August 2017

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2 August 2017

20

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2 August 2017

5708-5717

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2 August 2017

40

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204592

2 August 2017

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cites work

Control of the nuclear localization of Extradenticle by competing nuclear import and export signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The E2A gene product contains two separable and functionally distinct transcription activation domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Positive and negative regulation of V(D)J recombination by the E2A proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Role for homodimerization in growth deregulation by E2a fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

An inhibitory switch derepressed by pbx, hox, and Meis/Prep1 partners regulates DNA-binding by pbx1 and E2a-pbx1 and is dispensable for myeloid immortalization by E2a-pbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Meis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structure and developmental expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

mAngiogenin-3, a target gene of oncoprotein E2a-Pbx1, encodes a new angiogenic member of the angiogenin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Antagonism between extradenticle function and Hedgehog signalling in the developing limb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Selective repression of transcriptional activators by Pbx1 does not require the homeodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Nuclear import of the homeodomain protein extradenticle in response to Wg and Dpp signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The Homothorax homeoprotein activates the nuclear localization of another homeoprotein, extradenticle, and suppresses eye development in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Regulation of the expression of cyclin-dependent kinase inhibitor p21 by E2A and Id proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Nuclear translocation of extradenticle requires homothorax, which encodes an extradenticle-related homeodomain protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

B-cell-specific DNA binding by an E47 homodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Homeobox genes in hematopoiesis and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Chimeric oncoprotein E2a-Pbx1 induces apoptosis of hematopoietic cells by a p53-independent mechanism that is suppressed by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

extradenticle raises the DNA binding specificity of homeotic selector gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

The helix-loop-helix gene E2A is required for B cell formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

E47 activates the Ig-heavy chain and TdT loci in non-B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

7 January 2021

Involvement of the E2A basic helix-loop-helix protein in immunoglobulin heavy chain class switching

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

7 January 2021

Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : II. Zygotic loci on the third chromosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

7 January 2021

The highest affinity DNA element bound by Pbx complexes in t(1;19) leukemic cells fails to mediate cooperative DNA-binding or cooperative transactivation by E2a-Pbx1 and class I Hox proteins - evidence for selective targetting of E2a-Pbx1 to a subse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

7 January 2021

New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204592

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204592

1 reference

Dimensions Publication ID

2 August 2017

0 references

1 reference