(Q34405491)

2 August 2017

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title

Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma (English)

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2 August 2017

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F G Barr

1

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PubMed ID

11607823

2 August 2017

language of work or name

English

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publication date

1 September 2001

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2 August 2017

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2 August 2017

20

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2 August 2017

5736-5746

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2 August 2017

40

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1204599

2 August 2017

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cites work

Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

An exonic mutation in the HuP2 paired domain gene causes Waardenburg's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Chromosomal translocation t(1;13)(p36;q14) in a case of rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The COOH-terminal transactivation domain plays a key role in regulating the in vitro and in vivo function of Pax3 homeodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Molecular basis of splotch and Waardenburg Pax-3 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Identification of DNA recognition sequences for the Pax3 paired domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax-3 contains domains for transcription activation and transcription inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax genes and organogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

A specific chromosomal abnormality in rhabdomyosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax3 inhibits myogenic differentiation of cultured myoblast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax3 modulates expression of the c-Met receptor during limb muscle development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Tumor-specific PAX3-FKHR transcription factor, but not PAX3, activates the platelet-derived growth factor alpha receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Silencer elements modulate the expression of the gene for the neuron-glia cell adhesion molecule, Ng-CAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Five years on the wings of fork head

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Common and variant gene fusions predict distinct clinical phenotypes in rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Genomic organization of the human PAX3 gene: DNA sequence analysis of the region disrupted in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax-3 is necessary but not sufficient for lbx1 expression in myogenic precursor cells of the limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Identification of a new binding motif for the paired domain of Pax-3 and unusual characteristics of spacing of bipartite recognition elements on binding and transcription activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The diagnostic potential of the chromosome translocation t(2;13) in rhabdomyosarcoma: a Pcr study of fresh-frozen and paraffin-embedded tumour samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Molecular cloning and characterization of a human PAX-7 cDNA expressed in normal and neoplastic myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax7 is required for the specification of myogenic satellite cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Negative regulation of the forkhead transcription factor FKHR by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Involvement of IGF-II in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Pax: genes for mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

The genomic organization and the full coding region of the human PAX7 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Epistatic relationship between Waardenburg syndrome genes MITF and PAX3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

Molecular assays for chromosomal translocations in the diagnosis of pediatric soft tissue sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Structural analysis of PAX3 genomic rearrangements in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

The Splotch mutation interferes with muscle development in the limbs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Normal and rearranged PAX3 expression in human rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Pax3 and Regulation of the Melanocyte-specific Tyrosinase-related Protein-1 Promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Targeting tumor specific translocations in sarcomas in pediatric patients for immunotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Consistent chromosomal translocation in alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

The paired-domain regulates DNA binding by the homeodomain within the intact Pax-3 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204599

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1204599

1 reference

PubMed ID

11607823

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11607823