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CHK2 kinase--a busy messenger.
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Europe PubMed Central
PubMed ID
11733767
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
review article
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Europe PubMed Central
title
CHK2 kinase--a busy messenger
(English)
1 reference
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Europe PubMed Central
PubMed ID
11733767
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
author
Jiří Lukáš
series ordinal
3
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Europe PubMed Central
PubMed ID
11733767
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
author name string
Bartek J
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1
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Europe PubMed Central
PubMed ID
11733767
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
Falck J
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2
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Europe PubMed Central
PubMed ID
11733767
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
publication date
1 December 2001
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PubMed ID
11733767
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4 December 2019
published in
Nature Reviews Molecular Cell Biology
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Europe PubMed Central
PubMed ID
11733767
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4 December 2019
volume
2
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Europe PubMed Central
PubMed ID
11733767
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retrieved
4 December 2019
page(s)
877-886
1 reference
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Europe PubMed Central
PubMed ID
11733767
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
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4 December 2019
issue
12
1 reference
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Europe PubMed Central
PubMed ID
11733767
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
exact match
https://scigraph.springernature.com/pub.10.1038/35103059
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DNA damage and checkpoint pathways: molecular anatomy and interactions with repair
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Cell-cycle checkpoint kinases: checking in on the cell cycle
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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
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Cell cycle checkpoint signaling through the ATM and ATR kinases
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The DNA damage response: putting checkpoints in perspective
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Sensing and responding to DNA damage.
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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
1 reference
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Crossref
reference URL
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DNA double-strand breaks: signaling, repair and the cancer connection
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Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.
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Crossref
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The many substrates and functions of ATM
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7 January 2021
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ATM and ATR: networking cellular responses to DNA damage
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Crossref
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Ataxia-telangiectasia and the ATM gene: linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints
1 reference
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Crossref
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Crossref
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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
1 reference
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https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
1 reference
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Crossref
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7 January 2021
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A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
1 reference
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7 January 2021
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Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F35103059
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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
1 reference
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7 January 2021
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Crossref
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7 January 2021
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Crossref
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Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends
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Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair.
1 reference
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Crossref
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Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination
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A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment.
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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
1 reference
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Crossref
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1 reference
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Crossref
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1 reference
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1 reference
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Crossref
reference URL
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1 reference
stated in
Crossref
reference URL
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7 January 2021
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Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.
1 reference
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Crossref
reference URL
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7 January 2021
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Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
1 reference
stated in
Crossref
reference URL
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7 January 2021
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Crossref
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7 January 2021
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Mrc1 transduces signals of DNA replication stress to activate Rad53.
1 reference
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Crossref
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Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.
1 reference
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Crossref
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7 January 2021
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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1 reference
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1 reference
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Crossref
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1 reference
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Crossref
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inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
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7 January 2021
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inferred from DOI database lookup
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
1 reference
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Crossref
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Crossref
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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation
1 reference
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inferred from DOI database lookup
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25
1 reference
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Crossref
reference URL
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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
1 reference
stated in
Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.
1 reference
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Crossref
reference URL
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1 reference
stated in
Crossref
reference URL
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Rapid destruction of human Cdc25A in response to DNA damage
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
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inferred from DOI database lookup
Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
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The Mre11 complex and ATM: collaborating to navigate S phase
1 reference
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7 January 2021
based on heuristic
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Checking two steps
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced phosphorylation of p53 by ATM in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian G1- and S-phase checkpoints in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
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Screening hCHK2 for Mutations
1 reference
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Crossref
reference URL
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retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
inferred from DOI database lookup
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of tumor-associated Chk2 mutations
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
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Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
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ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation
1 reference
stated in
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reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
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7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F35103059
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/35103059
1 reference
stated in
Europe PubMed Central
PubMed ID
11733767
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
Dimensions Publication ID
1005636144
0 references
PubMed ID
11733767
1 reference
stated in
Europe PubMed Central
PubMed ID
11733767
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 December 2019
ResearchGate publication ID
11622098
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