(Q34460371)

English

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

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scholarly article

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Europe PubMed Central

2 August 2017

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS. (English)

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2 August 2017

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1 June 2020

Michael A Walters

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1 June 2020

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Jayme L Dahlin

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1 June 2020

Jessica M Strasser

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1 June 2020

Subhashree Francis

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1 June 2020

LeeAnn Higgins

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1 June 2020

Hui Zhou

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1 June 2020

Zhiguo Zhang

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21 February 2015

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Journal of Medicinal Chemistry

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1 June 2020

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1 June 2020

2091-2113

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1 June 2020

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1,2,4-thiadiazole: a novel Cathepsin B inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360378

27 October 2018

Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360378

27 October 2018

Synthesis and evaluation of novel dipeptide-bound 1,2,4-thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360378

27 October 2018

High-throughput screening for identification of small molecule inhibitors of histone acetyltransferases using scintillating microplates (FlashPlate).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360378

27 October 2018

New fluorochromes for thiols: maleimide and iodoacetamide derivatives of a 3-phenylcoumarin fluorophore.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360378

27 October 2018

Impact of impurities on IC50 values of P450 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[S-Sulfanilamido- and 3-sulfanilamido-1,2,4-thiadiazole]

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recommendations for the reduction of compound artifacts in time-resolved fluorescence resonance energy transfer assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple assay for detection of small-molecule redox activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A continuous, nonradioactive assay for histone acetyltransferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Application of a fluorescent histone acetyltransferase assay to probe the substrate specificity of the human p300/CBP-associated factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microfluorometric analysis of protein thiol groups with a coumarinylphenylmaleimide

1 reference

https://pubmed.ncbi.nlm.nih.gov/25634295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM5019093

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634295%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634295%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25634295%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

ResearchGate publication ID

0 references

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