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beta-Cell death during progression to diabetes
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
beta-Cell death during progression to diabetes
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
main subject
cell death
1 reference
based on heuristic
inferred from title
author name string
Mathis D
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
Vence L
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
Benoist C
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
language of work or name
English
0 references
publication date
1 December 2001
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
published in
Nature
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
volume
414
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
page(s)
792-798
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
issue
6865
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/414792a
0 references
cites work
Insulin-dependent diabetes mellitus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T helper cell subsets in insulin-dependent diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic control of diabetes progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The induction of tolerance by dendritic cells that have captured apoptotic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis and antiphospholipid antibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis in development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interdigital cell death can occur through a necrotic and caspase-independent pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell death in animal development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hormonal and metabolic changes in the perinatal period
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intolerable secretion in tolerant transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential requirement for caspase 9 in apoptotic pathways in vivo.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immune response to islets in experimental diabetes and insulin-dependent diabetes mellitus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta cell apoptosis in T cell-mediated autoimmune diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CD95's deadly mission in the immune system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of Fas in autoimmune diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of beta cell death in diabetes: a minor role for CD95.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptosis of pancreatic beta-cells detected in accelerated diabetes of NOD mice: no role of Fas-Fas ligand interaction in autoimmune diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Significant role for Fas in the pathogenesis of autoimmune diabetes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Monitoring gene expression of TNFR family members by beta-cells during development of autoimmune diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accelerated beta-cell destruction in adoptively transferred autoimmune diabetes correlates with an increased expression of the genes coding for TNF-alpha and granzyme A in the intra-islet infiltrates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are Beta-cell specific
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic effects of cytokines on rat islets: evidence for involvement of free radicals and lipid peroxidation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Unusual resistance of ALR/Lt mouse beta cells to autoimmune destruction: role for beta cell-expressed resistance determinants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transgenic overexpression of human Bcl-2 in islet β cells inhibits apoptosis but does not prevent autoimmune destruction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deconstructing type 2 diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human type 2 diabetes: morphological evidence for abnormal beta-cell function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
No decrease of the beta-cell mass in type 2 diabetic patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irreversibility of nutritionally induced NIDDM in Psammomys obesus is related to beta-cell apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Following a diabetogenic T cell from genesis through pathogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414792A
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/414792A
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
PubMed ID
11742411
1 reference
stated in
Europe PubMed Central
PubMed ID
11742411
retrieved
2 August 2017
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