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Mitochondrial function in normal and diabetic beta-cells
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scholarly article
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Europe PubMed Central
PubMed ID
11742413
retrieved
2 August 2017
review article
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Europe PubMed Central
title
Mitochondrial function in normal and diabetic beta-cells
(English)
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Europe PubMed Central
PubMed ID
11742413
retrieved
2 August 2017
author name string
Maechler P
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1
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
Wollheim CB
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2
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
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English
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publication date
1 December 2001
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
published in
Nature
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
volume
414
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
page(s)
807-812
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
issue
6865
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Europe PubMed Central
PubMed ID
11742413
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2 August 2017
exact match
https://scigraph.springernature.com/pub.10.1038/414807a
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Mitochondrial diseases in man and mouse
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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses
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Mitochondrial evolution
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Protein import into mitochondria
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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
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The free radical theory of aging matures
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Role of calcium ions in regulation of mammalian intramitochondrial metabolism
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Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death
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Metabolic coupling factors in pancreatic beta-cell signal transduction
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Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
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7 January 2021
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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
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7 January 2021
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Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes
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7 January 2021
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Stimulus-secretion coupling in pancreatic beta cells.
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7 January 2021
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The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint
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7 January 2021
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Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor
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Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations
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7 January 2021
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Triggering and amplifying pathways of regulation of insulin secretion by glucose
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7 January 2021
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Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+-Induced Exocytosis in Mouse Pancreatic B-Cells
1 reference
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7 January 2021
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Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets
1 reference
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7 January 2021
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Regulation of exocytosis in electrically permeabilized insulin-secreting cells. Evidence for Ca2+ dependent and independent secretion
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7 January 2021
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Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.
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The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.
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7 January 2021
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Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus
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Glucagon receptors on human islet cells contribute to glucose competence of insulin release
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7 January 2021
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Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge
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7 January 2021
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Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.
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cAMP-GEFII is a direct target of cAMP in regulated exocytosis
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7 January 2021
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Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells
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Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
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Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.
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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell
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7 January 2021
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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.
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7 January 2021
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GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.
1 reference
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7 January 2021
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Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell
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7 January 2021
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The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events
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7 January 2021
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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation
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7 January 2021
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Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.
1 reference
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7 January 2021
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Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.
1 reference
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Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas
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7 January 2021
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Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9.
1 reference
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Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
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Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
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7 January 2021
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A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Molecular and clinical aspects of mitochondrial diabetes mellitus
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7 January 2021
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A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.
1 reference
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7 January 2021
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In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243
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7 January 2021
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Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion
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7 January 2021
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Diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu)(UUR) mutation: insulin secretion and sensitivity
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Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations.
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7 January 2021
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Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Genetic determinants of type 2 diabetes
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7 January 2021
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Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance
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Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus
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7 January 2021
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Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus.
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7 January 2021
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Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
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Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
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Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.
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7 January 2021
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Aging and insulin secretion
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Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity
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7 January 2021
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Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice
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7 January 2021
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Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.
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Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action
1 reference
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
1 reference
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.
1 reference
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7 January 2021
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Regulation of fatty acid homeostasis in cells: novel role of leptin
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7 January 2021
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Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell
1 reference
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7 January 2021
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Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?
1 reference
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7 January 2021
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Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells
1 reference
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2F414807A
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7 January 2021
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Identifiers
DOI
10.1038/414807A
1 reference
stated in
Europe PubMed Central
PubMed ID
11742413
retrieved
2 August 2017
Dimensions Publication ID
1040179145
0 references
PubMed ID
11742413
1 reference
stated in
Europe PubMed Central
PubMed ID
11742413
retrieved
2 August 2017
ResearchGate publication ID
11615123
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