(Q34487125)

2 August 2017

1 reference

title

Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis (English)

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2 August 2017

W M Tong

1

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2 August 2017

U Cortes

series ordinal

2

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2 August 2017

Z Q Wang

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 November 2001

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Biochimica et Biophysica Acta

2 August 2017

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2 August 2017

1552

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2 August 2017

27-37

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2 August 2017

1

1 reference

Poly(ADP-ribose) polymerase: a molecular nick-sensor

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(adenosine diphosphoribose) synthesis in ultraviolet-irradiated xeroderma pigmentosum cells reconstituted with Micrococcus luteus UV endonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Regulation by phosphorylation of Xenopus laevis poly(ADP-ribose) polymerase enzyme activity during oocyte maturation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

DNA repair: PARP - another guardian angel?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly (ADP-ribose) polymerase, nitric oxide and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Cloning of cDNA encoding Drosophila poly(ADP-ribose) polymerase: leucine zipper in the auto-modification domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Molecular and biochemical features of poly (ADP-ribose) metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Role of poly(ADP-ribose) formation in DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

PARP is important for genomic stability but dispensable in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The response of Parp knockout mice against DNA damaging agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Role of DNA break-sensing molecule poly(ADP-ribose) polymerase (PARP) in cellular function and radiation toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

High incidence of sister chromatid exchanges and chromatid interchanges in the conditions of lowered activity of poly(ADP-ribose)polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Stimulation of intrachromosomal homologous recombination in mammalian cells by an inhibitor of poly(ADP-ribosylation)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

3-Aminobenzamide synergistically increases sister-chromatid exchanges in cells exposed to methyl methanesulfonate but not to ultraviolet light

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Telomeres and their control

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Telomere states and cell fates

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Ku80 is required for immunoglobulin isotype switching

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Male rats fed methyl- and folate-deficient diets with or without niacin develop hepatic carcinomas associated with decreased tissue NAD concentrations and altered poly(ADP-ribose) polymerase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Genetic instabilities in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Spontaneous DNA damage, genome instability, and cancer--when DNA replication escapes control.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The p53-deficient mouse: a model for basic and applied cancer studies

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Tumor suppressor gene mutations in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Abnormalities of chromosome No. 1 in human solid malignant tumours

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Preferential involvement of chromosome 1q in a primary breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Comparative genomic hybridization reveals complex genetic changes in primary breast cancer tumors and their cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Chromosome 1 abnormalities in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Comprehensive allelotyping of human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Allelotype analysis of hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Trisomy for chromosome 1q in a pontine astrocytoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Pediatric high-grade astrocytomas show chromosomal imbalances distinct from adult cases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Enhanced poly(ADP-ribosyl)ation after focal ischemia in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Failure of poly(ADP-ribose) polymerase cleavage by caspases leads to induction of necrosis and enhanced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Identification of interaction partners for the basic-helix-loop-helix protein E47.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Interaction of the transcription factor YY1 with human poly(ADP-ribosyl) transferase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

PolyADP-ribose polymerase is a coactivator for AP-2-mediated transcriptional activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A role of poly (ADP-ribose) polymerase in NF-kappaB transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase upregulates E2F-1 promoter activity and DNA pol alpha expression during early S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Poly(ADP-ribose) polymerase is a B-MYB coactivator

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The world according to PARP.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Higher plants possess two structurally different poly(ADP-ribose) polymerases.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2801%2900035-X

7 January 2021

10.1016/S0304-419X(01)00035-X

Identifiers

DOI

1 reference

2 August 2017

1 reference