(Q34487795)

2 August 2017

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title

Model organisms as a guide to mammalian aging (English)

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2 August 2017

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1

Heidi A Tissenbaum

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2 August 2017

2

Leonard Guarente

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PubMed ID

11782310

2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

11

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inferred from page(s)

published in

Developmental Cell

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2 August 2017

2

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2 August 2017

9-19

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2 August 2017

1

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Neurosecretory control of aging in Caenorhabditis elegans

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The role of PI 3-kinase in insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of lifespan by sensory perception in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Genes that prolong life: relationships of growth hormone and growth to aging and life span

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Dwarf mice and the ageing process.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A heady message for lifespan regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of longevity and stress resistance by Sch9 in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

1 reference

7 January 2021

Why only time will tell.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Alterations of life span in the nematode Caenorhabditis elegans under monoxenic culture conditions

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Signals from the reproductive system regulate the lifespan of C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Molecular cloning and characterization of a new insulin/IGF-like peptide of the nematode Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A C. elegans mutant that lives twice as long as wild type

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Non-ageing developmental variant of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Determination of life-span in Caenorhabditis elegans by four clock genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The genetics of caloric restriction in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Aging and resistance to oxidative damage in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Thermotolerance of a long-lived mutant of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Mitochondrial superoxide decreases yeast survival in stationary phase

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Caloric restriction and aging: an update

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Life span of individual yeast cells

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Calendar life span versus budding life span of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Extrachromosomal rDNA circles--a cause of aging in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Oxidative stress, caloric restriction, and aging

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2801%2900098-3

7 January 2021

10.1016/S1534-5807(01)00098-3

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11782310