(Q34490441)

2 August 2017

title

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast (English)

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2 August 2017

6

D Allan Drummond

1 reference

2 August 2017

Michael F Dion

2

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author name string

Kerry A Geiler-Samerotte

1

1 reference

2 August 2017

Bogdan A Budnik

3

1 reference

2 August 2017

Stephanie M Wang

4

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2 August 2017

Daniel L Hartl

5

1 reference

2 August 2017

language of work or name

English

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publication date

27 December 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

number of pages

6

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based on heuristic

inferred from page(s)

published in

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2 August 2017

volume

108

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2 August 2017

issue

2

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2 August 2017

page(s)

680-685

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The rate of the molecular clock and the cost of gratuitous protein synthesis

2 August 2017

cites work

1 reference

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Chaperonin overexpression promotes genetic variation and enzyme evolution

6 July 2018

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Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

6 July 2018

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Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.

6 July 2018

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

6 July 2018

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Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

6 July 2018

1 reference

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Misfolded proteins partition between two distinct quality control compartments

6 July 2018

1 reference

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Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

6 July 2018

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A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.

6 July 2018

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The cost of expression of Escherichia coli lac operon proteins is in the process, not in the products

6 July 2018

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Different requirements of the SWI/SNF complex for robust nucleosome displacement at promoters of heat shock factor and Msn2- and Msn4-regulated heat shock genes

6 July 2018

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Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast

6 July 2018

1 reference

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Positive-feedback loops as a flexible biological module

6 July 2018

1 reference

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Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation.

6 July 2018

1 reference

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Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

6 July 2018

1 reference

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Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

6 July 2018

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Molecular chaperones and protein quality control

6 July 2018

1 reference

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The YEASTRACT database: a tool for the analysis of transcription regulatory associations in Saccharomyces cerevisiae

6 July 2018

1 reference

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Why highly expressed proteins evolve slowly

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Optimality and evolutionary tuning of the expression level of a protein

6 July 2018

1 reference

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The origins of genome complexity

6 July 2018

1 reference

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Global analysis of protein expression in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

6 July 2018

1 reference

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Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Functional profiling of the Saccharomyces cerevisiae genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

6 July 2018

1 reference

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Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

6 July 2018

1 reference

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Mutations that suppress the thermosensitivity of green fluorescent protein

6 July 2018

1 reference

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The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Gratuitous overexpression of genes in Escherichia coli leads to growth inhibition and ribosome destruction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Genetic analysis of protein stability and function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Lack of evolutionary conservation at positions important for thermal stability in the yeast ODCase protein.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

The cytosolic protein response as a subcomponent of the wider heat shock response in Arabidopsis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

A single determinant dominates the rate of yeast protein evolution

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Virus induction of heat shock protein 70 reflects a general response to protein accumulation in the plant cytosol.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Highly expressed genes in yeast evolve slowly.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

Improved green fluorescent protein by molecular evolution using DNA shuffling

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3021021

27 October 2018

Identifiers

DOI

10.1073/PNAS.1017570108

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2 August 2017

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2 August 2017

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