(Q34499843)

2 August 2017

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title

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease (English)

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2 August 2017

Eugene W M Ng

1

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2 August 2017

David T Shima

2

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2 August 2017

Perry Calias

3

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2 August 2017

Emmett T Cunningham

4

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2 August 2017

David R Guyer

5

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2 August 2017

Anthony P Adamis

6

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2 August 2017

1 February 2006

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Nature Reviews Drug Discovery

2 August 2017

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2 August 2017

5

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2 August 2017

123-132

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2 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrd1955

2 August 2017

0 references

cites work

Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

1 reference

Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy

21 January 2018

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Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate

21 January 2018

1 reference

Intravitreous injections of vascular endothelial growth factor produce retinal ischemia and microangiopathy in an adult primate

21 January 2018

1 reference

Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization

21 January 2018

1 reference

Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment

21 January 2018

1 reference

Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate

21 January 2018

1 reference

Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

21 January 2018

1 reference

Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration

21 January 2018

1 reference

Alterations in Ca2+ cycling by lysoplasmenylcholine in adult rabbit ventricular myocytes

21 January 2018

1 reference

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

21 January 2018

1 reference

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase

31 March 2020

1 reference

HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1.

31 March 2020

1 reference

In vitro selection of RNA molecules that bind specific ligands

31 March 2020

1 reference

Bifunctional recombinant proteins in cancer therapy: cell penetrating peptide aptamers as inhibitors of growth factor signaling

31 March 2020

1 reference

Peptide aptamers: tools for biology and drug discovery

31 March 2020

1 reference

The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targets

31 March 2020

1 reference

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

31 March 2020

1 reference

Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution

31 March 2020

1 reference

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

31 March 2020

1 reference

Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor

31 March 2020

1 reference

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

31 March 2020

1 reference

Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.

31 March 2020

1 reference

Nucleic Acid Aptamers as Tools and Drugs: Recent Developments

31 March 2020

1 reference

Aptamers: an emerging class of therapeutics

31 March 2020

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RNA and DNA aptamers in cytomics analysis

31 March 2020

1 reference

Cytoplasmic RNA modulators of an inside-out signal-transduction cascade

31 March 2020

1 reference

Intramers as promising new tools in functional proteomics

31 March 2020

1 reference

Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor

31 March 2020

1 reference

A DNA aptamer as a new target-specific chiral selector for HPLC.

31 March 2020

1 reference

Adaptive recognition by nucleic acid aptamers

31 March 2020

1 reference

Natural and engineered nucleic acids as tools to explore biology

31 March 2020

1 reference

Prospects for antiviral ribozymes and deoxyribozymes

31 March 2020

1 reference

Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability

31 March 2020

1 reference

Toxicology of antisense therapeutics

31 March 2020

1 reference

Developing aptamers into therapeutics

31 March 2020

1 reference

In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class

31 March 2020

1 reference

Human antichimeric antibody in children and young adults with inflammatory bowel disease receiving infliximab

31 March 2020

1 reference

Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor

31 March 2020

1 reference

Vascular endothelial growth factor: basic science and clinical progress

31 March 2020

1 reference

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

31 March 2020

1 reference

Vascular endothelial growth factor is a secreted angiogenic mitogen

31 March 2020

1 reference

Vascular permeability factor, an endothelial cell mitogen related to PDGF

31 March 2020

1 reference

Oligonucleotide duplexes containing 2'-amino-2'-deoxycytidines: thermal stability and chemical reactivity

31 March 2020

1 reference

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes.

31 March 2020

1 reference

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

31 March 2020

1 reference

Pharmacokinetics and biodistribution of novel aptamer compositions

31 March 2020

1 reference

Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro

31 March 2020

1 reference

Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration

31 March 2020

1 reference

Solution structure of the heparin-binding domain of vascular endothelial growth factor

31 March 2020

1 reference

Detection and plasma pharmacokinetics of an anti-vascular endothelial growth factor oligonucleotide-aptamer (NX1838) in rhesus monkeys

31 March 2020

1 reference

Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys

31 March 2020

1 reference

VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells

31 March 2020

1 reference

Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor.

31 March 2020

1 reference

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

31 March 2020

1 reference

Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro

31 March 2020

1 reference

VEGF164Is Proinflammatory in the Diabetic Retina

31 March 2020

1 reference

Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors

31 March 2020

1 reference

VEGF: a critical player in neurodegeneration

31 March 2020

1 reference

Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal

31 March 2020

1 reference

Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

31 March 2020

1 reference

Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes

31 March 2020

1 reference

Pathologic features of vascular endothelial growth factor-induced retinopathy in the nonhuman primate

31 March 2020

1 reference

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins

31 March 2020

1 reference

VEGF164(165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2.

31 March 2020

1 reference

VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization.

31 March 2020

1 reference

31 March 2020

1 reference

Pegaptanib for neovascular age-related macular degeneration

31 March 2020

1 reference

Enhanced efficacy associated with early treatment of neovascular age-related macular degeneration with pegaptanib sodium: an exploratory analysis.

31 March 2020

1 reference

Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies

31 March 2020

1 reference

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema.

31 March 2020

1 reference

Risks of intravitreous injection: a comprehensive review

31 March 2020

1 reference

Controlled delivery of the anti-VEGF aptamer EYE001 with poly(lactic-co-glycolic)acid microspheres

31 March 2020

1 reference

Scleral permeability of a small, single-stranded oligonucleotide.

31 March 2020

1 reference

Spiegelmers: Biostable Aptamers

31 March 2020

1 reference

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

31 March 2020

1 reference

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival

31 March 2020

1 reference

Inhibitory DNA ligands to platelet-derived growth factor B-chain

31 March 2020

1 reference

Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus

31 March 2020

1 reference

Antidote-mediated control of an anticoagulant aptamer in vivo

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1955

1 reference

release_tpgcfxxwwbbsxazabvmb6j7pvq

2 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tpgcfxxwwbbsxazabvmb6j7pvq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference