(Q34520432)

2 August 2017

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title

Apoptosis: a link between cancer genetics and chemotherapy (English)

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2 August 2017

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Ricky W Johnstone

1

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author name string

Astrid A Ruefli

series ordinal

2

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2 August 2017

Scott W Lowe

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

108

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2 August 2017

153-164

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2 August 2017

2

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Proteasome inhibition in cancer: development of PS-341.

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Safety and antitumor activity of recombinant soluble Apo2 ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The role of p53 in tumour suppression: lessons from mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Stress management - heat shock protein-70 and the regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Unwinding the loop of Bcl-2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

P53-dependent and -independent links between DNA-damage, apoptosis and mutation frequency in ES cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Heat shock proteins--modulators of apoptosis in tumour cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Oncogenic alterations of metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Role of oncogenes in resistance and killing by cancer therapeutic agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Proliferation, cell cycle and apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Critical determinants of cancer metastasis: rationale for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Absence of p53 permits propagation of mutant cells following genotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Rb function in cell-cycle regulation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cellular stress response and apoptosis in cancer therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Apaf-1 protein deficiency confers resistance to cytochrome c-dependent apoptosis in human leukemic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Multiple physiological functions for multidrug transporter P-glycoprotein?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Overexpression of Bcl-x(L) promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

1 reference

7 January 2021

Histone deacetylase inhibitors as new cancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Breaking the mitochondrial barrier

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Defining CD95 as a tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

DNA methylation in genomic imprinting, development, and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Dysregulation of apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Tumor immunity in perforin-deficient mice: a role for CD95 (Fas/APO-1)

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Phosphatidylinositol 3-kinases in tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Role of NF-κB in p53-mediated programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Regulation and function of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Genetic analysis of chemoresistance in primary murine lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

1 reference

7 January 2021

Bcl-2 with loss of apoptosis allows accumulation of genetic alterations: A pathway to metastatic progression in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Regulation of PTEN transcription by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Telomerase activation by histone deacetylase inhibitor in normal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Antisense therapy in oncology: new hope for an old idea?

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Clinical implications of p53 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

P63 and P73: P53 mimics, menaces and more

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

Role of BAX in the apoptotic response to anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900625-6

7 January 2021

10.1016/S0092-8674(02)00625-6

Identifiers

DOI

1 reference

release_34bxk6gvobhvtgfmelcv3uiaxe

2 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/34bxk6gvobhvtgfmelcv3uiaxe

24 November 2022

mapped directly with Wikidata item

1 reference