(Q34533142)

2 August 2017

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title

The microbiota in adaptive immune homeostasis and disease (English)

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2 August 2017

2

Dan R Littman

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2 August 2017

Kenya Honda

1

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PubMed ID

27383982

2 August 2017

language of work or name

English

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publication date

6 July 2016

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2 August 2017

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2 August 2017

535

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2 August 2017

75-84

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2 August 2017

7610

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https://scigraph.springernature.com/pub.10.1038/nature18848

2 August 2017

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cites work

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

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12 December 2020

Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis

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12 December 2020

Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut

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12 December 2020

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

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12 December 2020

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

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12 December 2020

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

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12 December 2020

Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes

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12 December 2020

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

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12 December 2020

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

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12 December 2020

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

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12 December 2020

IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses

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12 December 2020

Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.

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12 December 2020

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

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12 December 2020

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells

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12 December 2020

An enteric virus can replace the beneficial function of commensal bacteria

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12 December 2020

MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells.

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12 December 2020

MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells

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12 December 2020

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

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12 December 2020

Growth and host interaction of mouse segmented filamentous bacteria in vitro

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12 December 2020

Interleukin-23 drives intestinal inflammation through direct activity on T cells

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12 December 2020

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes

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12 December 2020

Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system.

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12 December 2020

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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12 December 2020

Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine

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12 December 2020

GPR15-mediated homing controls immune homeostasis in the large intestine mucosa

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12 December 2020

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota.

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12 December 2020

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis

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12 December 2020

Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis

1 reference

12 December 2020

Microbial exposure during early life has persistent effects on natural killer T cell function

1 reference

12 December 2020

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

1 reference

12 December 2020

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

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12 December 2020

Antibody blocks acquisition of bacterial colonization through agglutination

1 reference

12 December 2020

IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.

1 reference

12 December 2020

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis

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12 December 2020

Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine.

1 reference

12 December 2020

T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation

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12 December 2020

Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

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12 December 2020

Fate mapping of IL-17-producing T cells in inflammatory responses

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12 December 2020

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity

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12 December 2020

CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut.

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12 December 2020

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.

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12 December 2020

Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut

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12 December 2020

Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation

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12 December 2020

Segmented filamentous bacterium uses secondary and tertiary lymphoid tissues to induce gut IgA and specific T helper 17 cell responses.

1 reference

12 December 2020

Identification of natural RORγ ligands that regulate the development of lymphoid cells

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12 December 2020

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

1 reference

12 December 2020

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

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12 December 2020

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

1 reference

12 December 2020

Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice

1 reference

12 December 2020

Commensal-dendritic-cell interaction specifies a unique protective skin immune signature

1 reference

12 December 2020

Induction of intestinal Th17 cells by segmented filamentous bacteria

1 reference

12 December 2020

Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells

1 reference

12 December 2020

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo

1 reference

12 December 2020

MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health

1 reference

12 December 2020

BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity

1 reference

12 December 2020

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

1 reference

12 December 2020

ATP drives lamina propria T(H)17 cell differentiation

1 reference

12 December 2020

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Induction of colonic regulatory T cells by indigenous Clostridium species

1 reference

12 December 2020

Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.

1 reference

12 December 2020

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

1 reference

12 December 2020

Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells

1 reference

12 December 2020

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

1 reference

12 December 2020

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity

1 reference

12 December 2020

The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis

1 reference

12 December 2020

The alarmin IL-33 promotes regulatory T-cell function in the intestine

1 reference

12 December 2020

Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

1 reference

12 December 2020

Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism

1 reference

12 December 2020

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

1 reference

12 December 2020

IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis

1 reference

12 December 2020

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection

1 reference

12 December 2020

Early life antibiotic-driven changes in microbiota enhance susceptibility to allergic asthma

1 reference

12 December 2020

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

1 reference

12 December 2020

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection

1 reference

12 December 2020

Bacterial flagellin is a dominant antigen in Crohn disease.

1 reference

12 December 2020

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

1 reference

12 December 2020

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.

1 reference

12 December 2020

Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy

1 reference

12 December 2020

VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

1 reference

12 December 2020

Commensal bacteria protect against food allergen sensitization

1 reference

12 December 2020

Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses

1 reference

12 December 2020

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

1 reference

12 December 2020

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

1 reference

12 December 2020

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

1 reference

12 December 2020

The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin

1 reference

12 December 2020

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner

1 reference

12 December 2020

Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells

1 reference

12 December 2020

Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice

1 reference

12 December 2020

IgA response to symbiotic bacteria as a mediator of gut homeostasis

1 reference

12 December 2020

Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice.

1 reference

12 December 2020

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition.

1 reference

12 December 2020

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

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12 December 2020

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

1 reference

12 December 2020

Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation

1 reference

12 December 2020

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

1 reference

12 December 2020

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

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12 December 2020

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice

1 reference

12 December 2020

The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment

1 reference

12 December 2020

CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.

1 reference

12 December 2020

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

1 reference

12 December 2020

Microbiota regulates immune defense against respiratory tract influenza A virus infection

1 reference

12 December 2020

Increased frequency of intestinal Escherichia coli carrying genes for S fimbriae and haemolysin in IgA-deficient individuals.

1 reference

12 December 2020

Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

1 reference

12 December 2020

Early infancy microbial and metabolic alterations affect risk of childhood asthma

1 reference

12 December 2020

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells

1 reference

12 December 2020

Characterization of the 17 strains of regulatory T cell-inducing human-derived Clostridia

1 reference

12 December 2020

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.

1 reference

12 December 2020

Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases

1 reference

12 December 2020

Regulatory T cells: mechanisms of differentiation and function

1 reference

12 December 2020

Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice

1 reference

12 December 2020

Induced CD4+Foxp3+ regulatory T cells in immune tolerance

1 reference

12 December 2020

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

1 reference

12 December 2020

New concepts in the generation and functions of IgA.

1 reference

12 December 2020

Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine

1 reference

12 December 2020

A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.

1 reference

12 December 2020

T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

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12 December 2020

Normalizing the environment recapitulates adult human immune traits in laboratory mice

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12 December 2020

The treatment-naive microbiome in new-onset Crohn's disease

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12 December 2020

Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.

1 reference

12 December 2020

Compartmentalized control of skin immunity by resident commensals

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12 December 2020

Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells

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12 December 2020

Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

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12 December 2020

Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells

1 reference

12 December 2020

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

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12 December 2020

Absence of MHC class II on cDCs results in microbial-dependent intestinal inflammation

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12 December 2020

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

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12 December 2020

Peripheral education of the immune system by colonic commensal microbiota.

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12 December 2020

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

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12 December 2020

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

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12 December 2020

Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses

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12 December 2020

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

1 reference

12 December 2020

Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses

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12 December 2020

Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease

1 reference

12 December 2020

Interleukin (IL)-21 promotes intestinal IgA response to microbiota

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12 December 2020

Intestinal microbial diversity during early-life colonization shapes long-term IgE levels

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12 December 2020

Identifiers

DOI

10.1038/NATURE18848

1 reference

2 August 2017

1 reference

PubMed ID

27383982