(Q34535628)

2 August 2017

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title

New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin (English)

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2 August 2017

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2

Elizabeth H Blackburn

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2 August 2017

Simon W-L Chan

1

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PubMed ID

11850780

2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

21

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2 August 2017

553-563

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2 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205082

2 August 2017

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cites work

Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Characterization of chromosome fragmentation in two protozoans and identification of a candidate fragmentation sequence in Euplotes crassus

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Pot1, the putative telomere end-binding protein in fission yeast and humans

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Functional multimerization of the human telomerase reverse transcriptase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Molecular manifestations and molecular determinants of telomere capping

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Switching and signaling at the telomere

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Altering telomere structure allows telomerase to act in yeast lacking ATM kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Disregulation of mitotic checkpoints and regulatory proteins following acute expression of SV40 large T antigen in diploid human cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere folding is required for the stable maintenance of telomere position effects in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere looping permits gene activation by a downstream UAS in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

A role for Saccharomyces cerevisiae histone H2A in DNA repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

All things must end: telomere dynamics in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Est1 and Cdc13 as comediators of telomerase access

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Identification of Kluyveromyces lactis telomerase: discontinuous synthesis along the 30-nucleotide-long templating domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

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7 January 2021

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Yeast Ku as a regulator of chromosomal DNA end structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Mammalian telomeres end in a large duplex loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Yeast heterochromatin: regulation of its assembly and inheritance by histones

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The many interfaces of Mre11

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase primer specificity and chromosome healing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere reduction in human colorectal carcinoma and with ageing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Elimination of Tec elements involves a novel excision process.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Specific association of human telomerase activity with immortal cells and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

TIN2, a new regulator of telomere length in human cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Rap1 protein regulates telomere turnover in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Sequence-specific DNA primer effects on telomerase polymerization activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Identification of human Rap1: implications for telomere evolution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

An alternative pathway for yeast telomere maintenance rescues est1- senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

A mutant with a defect in telomere elongation leads to senescence in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

A protein-counting mechanism for telomere length regulation in yeast.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Runaway telomere elongation caused by telomerase RNA gene mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomeres and their control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Accelerated telomere shortening in ataxia telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

DNA damage-dependent nuclear dynamics of the Mre11 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Yeast Ku protein plays a direct role in telomeric silencing and counteracts inhibition by rif proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Drosophila telomeres: two transposable elements with important roles in chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Functionally interacting telomerase RNAs in the yeast telomerase complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Specific telomerase RNA residues distant from the template are essential for telomerase function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Control of human telomere length by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The telochore: a telomeric differentiation of the chromosome axis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Origin of Concatemeric T7DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Evidence for a new step in telomere maintenance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomere lengthening and telomerase activation during human B cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Human telomerase contains two cooperating telomerase RNA molecules

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Human endothelial cell life extension by telomerase expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Developmentally programmed healing of chromosomes by telomerase in Tetrahymena

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205082

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.279.5349.349

Identifiers

DOI

10.1038/SJ.ONC.1205082

1 reference

PubMed ID

11850780

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11850780