(Q34543577)

2 August 2017

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title

CD28-mediated co-stimulation: a quantitative support for TCR signalling (English)

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2 August 2017

Oreste Acuto

1

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PubMed ID

14647476

2 August 2017

Frédérique Michel

series ordinal

2

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2 August 2017

1 December 2003

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Nature Reviews Immunology

2 August 2017

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2 August 2017

3

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2 August 2017

939-951

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2 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nri1248

2 August 2017

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cites work

Pathways for self-tolerance and the treatment of autoimmune diseases.

1 reference

Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen

31 March 2020

1 reference

31 March 2020

The B7-CD28 superfamily

1 reference

CD28/B7 system of T cell costimulation

31 March 2020

1 reference

Differential T cell costimulatory requirements in CD28-deficient mice

31 March 2020

1 reference

Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes.

31 March 2020

1 reference

CD28 costimulation and parasite dose combine to influence the susceptibility of BALB/c mice to infection with Leishmania major

31 March 2020

1 reference

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

31 March 2020

1 reference

Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model

31 March 2020

1 reference

Absence of B7-dependent responses in CD28-deficient mice

31 March 2020

1 reference

B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells

31 March 2020

1 reference

Cutting edge: a crucial role for B7-CD28 in transmitting T help from APC to CTL.

31 March 2020

1 reference

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

31 March 2020

1 reference

The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells

31 March 2020

1 reference

It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.

31 March 2020

1 reference

CD28 utilizes Vav-1 to enhance TCR-proximal signaling and NF-AT activation.

31 March 2020

1 reference

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

31 March 2020

1 reference

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

31 March 2020

1 reference

Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.

31 March 2020

1 reference

Coordinate regulation of T cell activation by CD2 and CD28

31 March 2020

1 reference

Molecular interactions mediating T cell antigen recognition

31 March 2020

1 reference

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

31 March 2020

1 reference

CD28 costimulation is required not only to induce IL-12 receptor but also to render janus kinases/STAT4 responsive to IL-12 stimulation in TCR-triggered T cells

31 March 2020

1 reference

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40.

31 March 2020

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Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells

31 March 2020

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Cutting edge: B7/CD28 interactions regulate cell cycle progression independent of the strength of TCR signaling

31 March 2020

1 reference

Immune responses in interleukin-2-deficient mice

31 March 2020

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Gamma chain required for naïve CD4+ T cell survival but not for antigen proliferation.

31 March 2020

1 reference

CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression

31 March 2020

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Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

31 March 2020

1 reference

An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation

31 March 2020

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Commitment point during G0-->G1 that controls entry into the cell cycle

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

31 March 2020

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Coordination of cell growth with cell division

31 March 2020

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TOR, a central controller of cell growth

31 March 2020

1 reference

Signaling networks that link cell proliferation and cell fate

31 March 2020

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

31 March 2020

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Pathways of apoptosis in lymphocyte development, homeostasis, and disease

31 March 2020

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T cell fitness determined by signal strength

31 March 2020

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31 March 2020

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

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The NF-kappa B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4+ lymphocytes

31 March 2020

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The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression

31 March 2020

1 reference

The lineage decisions of helper T cells

31 March 2020

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Progressive differentiation and selection of the fittest in the immune response

31 March 2020

1 reference

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

31 March 2020

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Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4.

31 March 2020

1 reference

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

31 March 2020

1 reference

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

31 March 2020

1 reference

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

31 March 2020

1 reference

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

31 March 2020

1 reference

The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation

31 March 2020

1 reference

T helper cell differentiation: on again, off again

31 March 2020

1 reference

c-Rel is required for chromatin remodeling across the IL-2 gene promoter

31 March 2020

1 reference

Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process

31 March 2020

1 reference

T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes.

31 March 2020

1 reference

Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

31 March 2020

1 reference

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

31 March 2020

1 reference

CD28: a signalling perspective.

31 March 2020

1 reference

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

31 March 2020

1 reference

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

31 March 2020

1 reference

CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

31 March 2020

1 reference

RasGRP is essential for mouse thymocyte differentiation and TCR signaling

31 March 2020

1 reference

Phosphoinositide 3-kinases in T lymphocyte activation

31 March 2020

1 reference

Direct observation of ligand recognition by T cells.

31 March 2020

1 reference

Upstream-downstream: CD28 cosignaling pathways and T cell function

31 March 2020

1 reference

The role of Tec protein-tyrosine kinase in T cell signaling

31 March 2020

1 reference

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line

31 March 2020

1 reference

Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.

31 March 2020

1 reference

Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells

31 March 2020

1 reference

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

31 March 2020

1 reference

Protein kinase B (Akt) regulation and function in T lymphocytes

31 March 2020

1 reference

A point mutation in CD28 distinguishes proliferative signals from survival signals

31 March 2020

1 reference

Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

31 March 2020

1 reference

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

31 March 2020

1 reference

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines

31 March 2020

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Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

31 March 2020

1 reference

The CD28 signaling pathway regulates glucose metabolism

31 March 2020

1 reference

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

31 March 2020

1 reference

A receptor/cytoskeletal movement triggered by costimulation during T cell activation

31 March 2020

1 reference

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

31 March 2020

1 reference

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

31 March 2020

1 reference

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

31 March 2020

1 reference

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

31 March 2020

1 reference

Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.

31 March 2020

1 reference

Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription

31 March 2020

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CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation

31 March 2020

1 reference

Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling

31 March 2020

1 reference

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

31 March 2020

1 reference

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

31 March 2020

1 reference

Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules

31 March 2020

1 reference

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

31 March 2020

1 reference

Differential requirement for SLP-76 domains in T cell development and function

31 March 2020

1 reference

The Actin Cytoskeleton and Lymphocyte Activation

31 March 2020

1 reference

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

31 March 2020

1 reference

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

31 March 2020

1 reference

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

31 March 2020

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Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

31 March 2020

1 reference

CD28 Signaling via VAV/SLP-76 Adaptors

31 March 2020

1 reference

The enhanceosome and transcriptional synergy.

31 March 2020

1 reference

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

31 March 2020

1 reference

Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation

31 March 2020

1 reference

Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes

31 March 2020

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JNK is involved in signal integration during costimulation of T lymphocytes.

31 March 2020

1 reference

CD28 is not required for c-Jun N-terminal kinase activation in T cells

31 March 2020

1 reference

New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

31 March 2020

1 reference

CD28 affects the earliest signaling events generated by TCR engagement.

31 March 2020

1 reference

T lymphocyte costimulation mediated by reorganization of membrane microdomains

31 March 2020

1 reference

The immunological synapse and CD28-CD80 interactions.

31 March 2020

1 reference

Proline residues in CD28 and the Src homology (SH)3 domain of Lck are required for T cell costimulation

31 March 2020

1 reference

ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28.

31 March 2020

1 reference

CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

31 March 2020

1 reference

Live-cell dynamics and the role of costimulation in immunological synapse formation

31 March 2020

1 reference

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

31 March 2020

1 reference

Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation

31 March 2020

1 reference

Staging and resetting T cell activation in SMACs

31 March 2020

1 reference

The duration of antigenic stimulation determines the fate of naive and effector T cells.

31 March 2020

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Regulation of Lck activity by CD4 and CD28 in the immunological synapse

31 March 2020

1 reference

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

31 March 2020

1 reference

CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation

31 March 2020

1 reference

Calcium signaling mechanisms in T lymphocytes

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

1 reference

CD28, Ox-40, LFA-1, and CD4 modulation of Th1/Th2 differentiation is directly dependent on the dose of antigen.

31 March 2020

1 reference

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival

31 March 2020

1 reference

Duration of TCR stimulation determines costimulatory requirement of T cells

31 March 2020

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Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

31 March 2020

1 reference

Protein kinase C-theta;: signaling from the center of the T-cell synapse

31 March 2020

1 reference

Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

31 March 2020

1 reference

Positive and negative regulation of T-cell activation by adaptor proteins

31 March 2020

1 reference

Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap

31 March 2020

1 reference

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

31 March 2020

1 reference

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

31 March 2020

1 reference

Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain

31 March 2020

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

31 March 2020

1 reference

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

31 March 2020

1 reference

CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection

31 March 2020

1 reference

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Identifiers

DOI

10.1038/NRI1248

1 reference

PubMed ID

14647476

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

14647476