(Q34553662)

3 August 2017

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title

Cell-based systems to assess nuclear receptor activation and their use in drug development (English)

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3 August 2017

Judy L Raucy

1

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3 August 2017

Jerome M Lasker

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 February 2013

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3 August 2017

published in

Drug Metabolism Reviews

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3 August 2017

volume

45

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3 August 2017

issue

1

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3 August 2017

page(s)

101-109

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Alternatively spliced isoforms of the human constitutive androstane receptor

3 August 2017

cites work

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21 January 2018

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Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme

21 January 2018

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Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes

21 January 2018

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The nuclear receptor superfamily: a personal retrospect on the first two decades

21 January 2018

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Coactivators in assay design for nuclear hormone receptor drug discovery

21 January 2018

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In vitro and in vivo induction of cytochrome p450: a survey of the current practices and recommendations: a pharmaceutical research and manufacturers of america perspective

21 January 2018

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Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells

21 January 2018

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Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

21 January 2018

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Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

21 January 2018

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The nuclear receptor PXR: a master regulator of "homeland" defense

21 January 2018

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Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

21 January 2018

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Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

21 January 2018

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Evaluation of models for predicting drug–drug interactions due to induction

21 January 2018

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Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site

21 January 2018

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Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins.

21 January 2018

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Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

21 January 2018

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The aryl hydrocarbon receptor complex

21 January 2018

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Activation of the Ah receptor by tryptophan and tryptophan metabolites

21 January 2018

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Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

21 January 2018

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A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

21 January 2018

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Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

21 January 2018

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Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element

21 January 2018

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DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region

21 January 2018

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Cytochrome P450 gene regulation and physiological functions mediated by the aryl hydrocarbon receptor

21 January 2018

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

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Exposure to PAH compounds among cokery workers in the oil shale industry

21 January 2018

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The structure of the nuclear hormone receptors

21 January 2018

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

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A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

21 January 2018

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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

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Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

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The RXR heterodimers and orphan receptors

21 January 2018

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Use of the nuclear receptor PXR to predict drug interactions

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities

21 January 2018

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The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).

21 January 2018

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Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin

21 January 2018

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Current in vitro high throughput screening approaches to assess nuclear receptor activation

21 January 2018

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Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Identification of Clinically Used Drugs That Activate Pregnane X Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The utility of stable cell lines to assess species differences in PXR transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Diet, fatty acids, and regulation of genes important for heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Role of constitutive androstane receptor in the in vivo induction of Mrp3 and CYP2B1/2 by phenobarbital.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2012.737333

10.3109/03602532.2012.737333

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference