(Q34561019)

3 August 2017

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title

Breaking barriers to transcription elongation (English)

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3 August 2017

Abbie Saunders

1

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3 August 2017

Leighton J Core

series ordinal

2

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3 August 2017

John T Lis

series ordinal

3

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3 August 2017

1 August 2006

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Nature Reviews Molecular Cell Biology

3 August 2017

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3 August 2017

7

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3 August 2017

557-567

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3 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrm1981

3 August 2017

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cites work

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21 January 2018

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Promoting elongation with transcript cleavage stimulatory factors

21 January 2018

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RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells

21 January 2018

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Postinitiation transcriptional control in Drosophila melanogaster

21 January 2018

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The RNA polymerase II transcription cycle: cycling through chromatin

21 January 2018

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Human Elongator facilitates RNA polymerase II transcription through chromatin

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RNA polymerase II carboxy-terminal domain kinases: emerging clues to their function

21 January 2018

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Elongation by RNA polymerase II: the short and long of it

31 March 2020

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Transcription Factor and Polymerase Recruitment, Modification, and Movement on dhsp70 In Vivo in the Minutes following Heat Shock

31 March 2020

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Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription

31 March 2020

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Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans.

31 March 2020

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Genome-wide map of nucleosome acetylation and methylation in yeast

31 March 2020

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Structure and mechanism of the RNA polymerase II transcription machinery

31 March 2020

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RNA polymerase II structure: from core to functional complexes

31 March 2020

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Polymerase II promoter activation: closed complex formation and ATP-driven start site opening

31 March 2020

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Three transitions in the RNA polymerase II transcription complex during initiation

31 March 2020

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A kinetic model for the early steps of RNA synthesis by human RNA polymerase II.

31 March 2020

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A functional role for the switch 2 region of yeast RNA polymerase II in transcription start site utilization and abortive initiation

31 March 2020

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Functional interaction between TFIIB and the Rpb2 subunit of RNA polymerase II: implications for the mechanism of transcription initiation

31 March 2020

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Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 Angstroms

31 March 2020

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The initiation-elongation transition: lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23.

31 March 2020

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An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation

31 March 2020

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The role of the transcription bubble and TFIIB in promoter clearance by RNA polymerase II

31 March 2020

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Structural basis of transcription: separation of RNA from DNA by RNA polymerase II

31 March 2020

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The sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by RNA polymerase II in vitro

31 March 2020

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RNA polymerase II transcription complexes may become arrested if the nascent RNA is shortened to less than 50 nucleotides

31 March 2020

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RNA emerging from the active site of RNA polymerase II interacts with the Rpb7 subunit.

31 March 2020

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Dissociable Rpb4-Rpb7 subassembly of rna polymerase II binds to single-strand nucleic acid and mediates a post-recruitment step in transcription initiation.

31 March 2020

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The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation.

31 March 2020

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Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation

31 March 2020

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Promoter melting and TFIID complexes on Drosophila genes in vivo

31 March 2020

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The RNA polymerase II molecule at the 5' end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged.

31 March 2020

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In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes

31 March 2020

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Antitermination by bacteriophage lambda Q protein

31 March 2020

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A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation

31 March 2020

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Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing

31 March 2020

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A high-resolution map of active promoters in the human genome

31 March 2020

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P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II

31 March 2020

1 reference

Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae

31 March 2020

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Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex

31 March 2020

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Molecular characterization of Drosophila NELF

31 March 2020

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High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation

31 March 2020

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A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS.

31 March 2020

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Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element

31 March 2020

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A regulator of transcriptional elongation controls vertebrate neuronal development

31 March 2020

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Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.

31 March 2020

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Transcription elongation factor hSPT5 stimulates mRNA capping

31 March 2020

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Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control

31 March 2020

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P-TEFb-mediated phosphorylation of hSpt5 C-terminal repeats is critical for processive transcription elongation.

31 March 2020

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Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II

31 March 2020

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Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS.

31 March 2020

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Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo

31 March 2020

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Molecular evidence for a positive role of Spt4 in transcription elongation

31 March 2020

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Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes

31 March 2020

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CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo

31 March 2020

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

31 March 2020

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P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes

31 March 2020

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Cellular control of gene expression by T-type cyclin/CDK9 complexes

31 March 2020

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

31 March 2020

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Transcription elongation and human disease

31 March 2020

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Dual roles for transcription factor IIF in promoter escape by RNA polymerase II.

31 March 2020

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RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach

31 March 2020

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Recycling of the general transcription factors during RNA polymerase II transcription

31 March 2020

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Mechanism of Action of RNA Polymerase II Elongation Factor Elongin

31 March 2020

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Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A.

31 March 2020

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Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo

31 March 2020

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Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

31 March 2020

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Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome

31 March 2020

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The anti-cancer drug camptothecin inhibits elongation but stimulates initiation of RNA polymerase II transcription.

31 March 2020

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Single-nucleosome mapping of histone modifications in S. cerevisiae

31 March 2020

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Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

31 March 2020

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Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun

31 March 2020

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Requirement of Hos2 histone deacetylase for gene activity in yeast

31 March 2020

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Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

31 March 2020

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Transcriptional inhibition of genes with severe histone h3 hypoacetylation in the coding region

31 March 2020

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Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia

31 March 2020

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Mapping global histone acetylation patterns to gene expression

31 March 2020

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Genomic characterization reveals a simple histone H4 acetylation code.

31 March 2020

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Histone H4-K16 acetylation controls chromatin structure and protein interactions

31 March 2020

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The SET-domain protein superfamily: protein lysine methyltransferases

31 March 2020

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Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

31 March 2020

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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

31 March 2020

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Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity

31 March 2020

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Global and Hox-specific roles for the MLL1 methyltransferase

31 March 2020

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Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide

31 March 2020

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Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II

31 March 2020

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Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

31 March 2020

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The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation

31 March 2020

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A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation

31 March 2020

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Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase

31 March 2020

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Drosophila Paf1 modulates chromatin structure at actively transcribed genes.

31 March 2020

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Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II

31 March 2020

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Rad6 plays a role in transcriptional activation through ubiquitylation of histone H2B.

31 March 2020

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Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

31 March 2020

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Histone H2B ubiquitylation is associated with elongating RNA polymerase II

31 March 2020

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Protein phosphatase 2A activity affects histone H3 phosphorylation and transcription in Drosophila melanogaster

31 March 2020

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Gene silencing: trans-histone regulatory pathway in chromatin

31 March 2020

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Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.

31 March 2020

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Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

31 March 2020

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Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

31 March 2020

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Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation

31 March 2020

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Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

31 March 2020

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Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation

31 March 2020

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Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex.

31 March 2020

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Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

31 March 2020

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

31 March 2020

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The human PAF complex coordinates transcription with events downstream of RNA synthesis

31 March 2020

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The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

31 March 2020

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The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

31 March 2020

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Chromatin remodeling by ATP-dependent molecular machines.

31 March 2020

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Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation

31 March 2020

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Domain-wide displacement of histones by activated heat shock factor occurs independently of Swi/Snf and is not correlated with RNA polymerase II density

31 March 2020

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Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.

31 March 2020

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Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes

31 March 2020

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The Drosophila BRM complex facilitates global transcription by RNA polymerase II

31 March 2020

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CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes

31 March 2020

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The chromo domain protein chd1p from budding yeast is an ATP-dependent chromatin-modifying factor

31 March 2020

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The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II.

31 March 2020

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Assembly of variant histones into chromatin

31 March 2020

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FACT facilitates transcription-dependent nucleosome alteration

31 March 2020

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Evidence that Spt6p controls chromatin structure by a direct interaction with histones

31 March 2020

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Transcription elongation factors repress transcription initiation from cryptic sites.

31 March 2020

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The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo

31 March 2020

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Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo

31 March 2020

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Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster

31 March 2020

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Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro

31 March 2020

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Interaction between transcription elongation factors and mRNA 3'-end formation at the Saccharomyces cerevisiae GAL10-GAL7 locus.

31 March 2020

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Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription

31 March 2020

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Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.

31 March 2020

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Removal of promoter nucleosomes by disassembly rather than sliding in vivo.

31 March 2020

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Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities

31 March 2020

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Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo

31 March 2020

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Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest

31 March 2020

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Integrating mRNA processing with transcription

31 March 2020

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Pcf11 is a termination factor in Drosophila that dismantles the elongation complex by bridging the CTD of RNA polymerase II to the nascent transcript.

31 March 2020

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A ribonucleolytic rat torpedoes RNA polymerase II.

31 March 2020

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A structural perspective of CTD function

31 March 2020

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Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain

31 March 2020

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The nucleosome: from genomic organization to genomic regulation

31 March 2020

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

31 March 2020

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DNA melting on yeast RNA polymerase II promoters

31 March 2020

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Initially transcribed sequences strongly affect the extent of abortive initiation by RNA polymerase II

31 March 2020

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Rad6-dependent ubiquitination of histone H2B in yeast

31 March 2020

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A conserved RING finger protein required for histone H2B monoubiquitination and cell size control.

31 March 2020

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Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter

31 March 2020

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Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1981

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Dimensions Publication ID

3 August 2017

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