(Q34572179)

3 August 2017

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title

Positive and negative regulation of T-cell activation by adaptor proteins (English)

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3 August 2017

Koretzky GA

1

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PubMed ID

11905825

3 August 2017

Myung PS

series ordinal

2

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3 August 2017

1 November 2001

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Nature Reviews Immunology

3 August 2017

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3 August 2017

1

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3 August 2017

95-107

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3 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/35100523

3 August 2017

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cites work

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1 reference

Antigen receptor tail clue.

21 January 2018

1 reference

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein

21 January 2018

1 reference

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases

21 January 2018

1 reference

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

21 January 2018

1 reference

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

21 January 2018

1 reference

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

21 January 2018

1 reference

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

1 reference

Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

21 January 2018

1 reference

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 January 2018

1 reference

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

21 January 2018

1 reference

Essential role of LAT in T cell development

21 January 2018

1 reference

Protein tyrosine kinases in thymocyte development

21 January 2018

1 reference

T cell receptor-mediated signs and signals governing T cell development

21 January 2018

1 reference

Branching out to gain control: how the pre-TCR is linked to multiple functions

21 January 2018

1 reference

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

1 reference

Recruitment of SLP-76 to the membrane and glycolipid-enriched membrane microdomains replaces the requirement for linker for activation of T cells in T cell receptor signaling

21 January 2018

1 reference

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

21 January 2018

1 reference

Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

1 reference

Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

21 January 2018

1 reference

Suppression of thymic development by the dominant-negative form of Gads.

21 January 2018

1 reference

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.

21 January 2018

1 reference

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

1 reference

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 January 2018

1 reference

SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

21 January 2018

1 reference

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

21 January 2018

1 reference

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 January 2018

1 reference

Direct or C5a-induced activation of heterotrimeric Gi2 proteins in human neutrophils is associated with interaction between formyl peptide receptors and the cytoskeleton.

21 January 2018

1 reference

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

21 January 2018

1 reference

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

21 January 2018

1 reference

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

1 reference

Localized Rac activation dynamics visualized in living cells

21 January 2018

1 reference

Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

21 January 2018

1 reference

A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity

21 January 2018

1 reference

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin

21 January 2018

1 reference

Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylation

21 January 2018

1 reference

Csk controls antigen receptor-mediated development and selection of T-lineage cells.

21 January 2018

1 reference

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

21 January 2018

1 reference

Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

21 January 2018

1 reference

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

21 January 2018

1 reference

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

21 January 2018

1 reference

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

21 January 2018

1 reference

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

1 reference

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

21 January 2018

1 reference

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

21 January 2018

1 reference

Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323

21 January 2018

1 reference

A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells

21 January 2018

1 reference

The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 January 2018

1 reference

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

1 reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

1 reference

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

1 reference

Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration

21 January 2018

1 reference

Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog

21 January 2018

1 reference

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

21 January 2018

1 reference

A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family

21 January 2018

1 reference

Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands

21 January 2018

1 reference

Characterization of the actin binding properties of the vasodilator-stimulated phosphoprotein VASP.

21 January 2018

1 reference

The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding, and actin bundle formation

21 January 2018

1 reference

Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes

21 January 2018

1 reference

Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

21 January 2018

1 reference

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

21 January 2018

1 reference

The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors

21 January 2018

1 reference

Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

21 January 2018

1 reference

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

21 January 2018

1 reference

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

21 January 2018

1 reference

The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.

21 January 2018

1 reference

Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function

21 January 2018

1 reference

Structure of the enabled/VASP homology 1 domain-peptide complex: a key component in the spatial control of actin assembly

21 January 2018

1 reference

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

21 January 2018

1 reference

Requirement for B cell linker protein (BLNK) in B cell development

21 January 2018

1 reference

Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65

21 January 2018

1 reference

Coupling of the TCR to integrin activation by Slap-130/Fyb.

21 January 2018

1 reference

Transmembrane Phosphoprotein Cbp Positively Regulates the Activity of the Carboxyl-terminal Src Kinase, Csk

21 January 2018

1 reference

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

21 January 2018

1 reference

VASP dynamics during lamellipodia protrusion

21 January 2018

1 reference

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

21 January 2018

1 reference

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

Requirement for the SLP-76 adaptor GADS in T cell development

21 January 2018

1 reference

7 January 2021

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

7 January 2021

Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner

1 reference

7 January 2021

A localized GTPase exchange factor, Bud5, determines the orientation of division axes in yeast

1 reference

7 January 2021

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

7 January 2021

Analysis, purification and properties of a 50,000-dalton membrane-associated phosphoprotein from human platelets

1 reference

7 January 2021

Negative regulation of fibroblast motility by Ena/VASP proteins

1 reference

7 January 2021

LAT is essential for Fc(epsilon)RI-mediated mast cell activation

1 reference

7 January 2021

B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice

1 reference

7 January 2021

Identifiers

DOI

10.1038/35100523

1 reference

PubMed ID

11905825

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

11905825