(Q34605237)

3 August 2017

1 reference

title

The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia (English)

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3 August 2017

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1 reference

Lee JT Jr

1

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PubMed ID

11960326

3 August 2017

McCubrey JA

series ordinal

2

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3 August 2017

1 April 2002

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3 August 2017

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3 August 2017

16

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3 August 2017

486-507

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3 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2402460

3 August 2017

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7 January 2021

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

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7 January 2021

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

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7 January 2021

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

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7 January 2021

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

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7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

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7 January 2021

Raf-1 activates MAP kinase-kinase

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7 January 2021

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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7 January 2021

A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors.

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Serine/threonine phosphorylation in cytokine signal transduction

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The p38 MAP kinase pathway and its biological function

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

From receptors to stress-activated MAP kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

1 reference

7 January 2021

Mechanism of action and in vivo role of platelet-derived growth factor

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

EGF receptor in neoplasia and metastasis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Insulin-like growth factor-II in endocrine pancreatic tumours. Immunohistochemical, biochemical and in situ hybridization findings

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The haematopoietic effects of growth hormone and insulin-like growth factor-I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 during maintenance chemotherapy of acute lymphoblastic leukemia in children

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

IGF-I receptor signalling in transformation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Influence of antibodies against IGF-I, insulin or their receptors on proliferation of human acute lymphoblastic leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Interferon-alpha therapy increases type I insulin-like growth factor receptors expression on lymphoid cells from patients with chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

PDGF-D, a new protease-activated growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Characterization of the chronic myelomonocytic leukemia associated TEL-PDGF beta R fusion protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Platelet-derived growth factor expression in accelerated and blastic phase of chronic myelogenous leukaemia with myelofibrosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Substantial inhibition of neo-intimal response to balloon injury in the rat carotid artery using a combination of antibodies to platelet-derived growth factor-BB and basic fibroblast growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A monoclonal antibody against PDGF B-chain inhibits PDGF-induced DNA synthesis in C3H fibroblasts and prevents binding of PDGF to its receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by platelet-derived growth factor and insulin-like growth factor-I. Possible involvement of cyclin-dependent kinase 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Functional importance of platelet-derived growth factor (PDGF) receptor extracellular immunoglobulin-like domains. Identification of PDGF binding site and neutralizing monoclonal antibodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Structure-activity relationships for 5-substituted 1-phenylbenzimidazoles as selective inhibitors of the platelet-derived growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Beneficial effects of a novel inhibitor of platelet-derived growth factor receptor autophosphorylation in the rat with mesangial proliferative glomerulonephritis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

STI571: targeting BCR-ABL as therapy for CML.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

STI571: a gene product-targeted therapy for leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Platelet-derived growth factor receptor tyrosine kinase inhibitor AG1295 attenuates rat hepatic stellate cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Differential effects of retroviral long terminal repeats on interleukin-3 gene expression and autocrine transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Characterization of proteins binding the 3' regulatory region of the IL-3 gene in IL-3-dependent and autocrine-transformed hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common beta subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Diphtheria toxin fused to human interleukin-3 is toxic to blasts from patients with myeloid leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Targeting myeloid leukemia with a DT(390)-mIL-3 fusion immunotoxin: ex vivo and in vivo studies in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The enhanced in vitro hematopoietic activity of leridistim, a chimeric dual G-CSF and IL-3 receptor agonist

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways cooperate in mediating cytokine-induced proliferation of a leukemic cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Blocking oncogenic Ras signaling for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Isotype-specific functions of Raf kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Kinases: positive and negative regulators of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Suppression of apoptosis: role in cell growth and neoplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Synergy between Raf and BCL2 in abrogating the cytokine dependency of hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Oncogene amplification in urothelial cancers with p53 gene mutation or MDM2 amplification.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Rat c-raf oncogene activation by a rearrangement that produces a fused protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Complex formation between RAS and RAF and other protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Src family protein tyrosine kinases and cellular signal transduction pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

P21(Cip1) induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

RNA aptamers that specifically bind to the Ras-binding domain of Raf-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

In vitro inhibition of Ras-Raf association by short peptides.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Exposure of human vascular smooth muscle cells to Raf-1 antisense oligodeoxynucleotides: cellular responses and pharmacodynamic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein kinase C alpha activates RAF-1 by direct phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Signaling by the cytokine receptor superfamily: JAKs and STATs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Role of tyrosine kinases in induction of the c-jun proto-oncogene in irradiated B-lineage lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

28 Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

KSR modulates signal propagation within the MAPK cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Isolation of MEK5 and differential expression of alternatively spliced forms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The inhibition of ERK/MAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MAP kinase pathway signalling is essential for extracellular matrix determined mammary epithelial cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of mitogen-activated kinase signaling sensitizes HeLa cells to Fas receptor-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Development of anticancer drugs targeting the MAP kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MAP kinases in mitogenesis and development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Dimerization in MAP-kinase signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The MAPK signaling cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Generation of constitutively active p90 ribosomal S6 kinase in vivo. Implications for the mitogen-activated protein kinase-activated protein kinase family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Competitive inhibition of MAP kinase activation by a peptide representing the alpha C helix of ERK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Evidence for two catalytically active kinase domains in pp90rsk

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Human rsk isoforms: cloning and characterization of tissue-specific expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transcription factors and translocations in lymphoid and myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

CREB and its associated proteins act as survival factors for human melanoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Granulocyte-macrophage colony-stimulating factor and interleukin-3 signaling pathways converge on the CREB-binding site in the human egr-1 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of target genes of oncogenic transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Repression of cyclin D1: a novel function of MYC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The ornithine decarboxylase gene is a transcriptional target of c-Myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Androgen receptor-Ets protein interaction is a novel mechanism for steroid hormone-mediated down-modulation of matrix metalloproteinase expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

AP-1 in cell proliferation and survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Expression of a down-regulated target, SSeCKS, reverses v-Jun-induced transformation of 10T1/2 murine fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transcriptional control of SPARC by v-Jun and other members of the AP1 family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylated CREB binds specifically to the nuclear protein CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

AP-1--Introductory remarks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Cellular transformation and malignancy induced by ras require c-jun

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

NF-kappa B: ten years after

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identification of the c-myc oncogene product in normal and malignant B cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The protein encoded by the human proto-oncogene c-myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The role of c-myc in cellular growth control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Myc/Max/Mad network and the transcriptional control of cell behavior

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Inhibition of cell proliferation by the Mad1 transcriptional repressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Max network gone mad.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

c-Myc transactivation domain-associated kinases: questionable role for map kinases in c-Myc phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The transactivation potential of a c-Myc N-terminal region (residues 92-143) is regulated by growth factor/Ras signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ras enhances Myc protein stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of c-myc expression by Ras/Raf signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The Ets family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ets target genes: past, present and future

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Signal transduction and the Ets family of transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein phosphatases and the regulation of mitogen-activated protein kinase signalling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Dual specificity phosphatases: a gene family for control of MAP kinase function.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44MAPK cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Feedback regulation of Raf-1 and mitogen-activated protein kinase (MAP) kinase kinases 1 and 2 by MAP kinase phosphatase-1 (MKP-1).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Role of protein phosphatase 2A in the regulation of mitogen-activated protein kinase activity in ventricular cardiomyocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The akt kinase: molecular determinants of oncogenicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Ceramide regulates cellular homeostasis via diverse stress signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402460

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2402460

1 reference

PubMed ID

11960326

Dimensions Publication ID

3 August 2017

0 references

1 reference

PubMed ID

11960326