(Q34606002)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

review article

1 reference

title

G-protein-coupled receptors and cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor

24 December 2019

main subject

0 references

author

J. Silvio Gutkind

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

author name string

Robert T Dorsam

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

language of work or name

English

0 references

publication date

1 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

page(s)

79-94

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc2069

24 December 2019

exact match

0 references

cites work

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Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

31 March 2020

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G-protein-coupled receptors and signaling networks: emerging paradigms.

31 March 2020

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Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation

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Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

31 March 2020

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G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity

31 March 2020

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Thrombin signalling and protease-activated receptors

31 March 2020

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Thrombin receptor overexpression in malignant and physiological invasion processes

31 March 2020

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Expression of protease-activated receptor 1 in oral squamous cell carcinoma

31 March 2020

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G proteins in cancer: the prostate cancer paradigm

31 March 2020

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Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer

31 March 2020

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Autocrine and paracrine signaling through neuropeptide receptors in human cancer

31 March 2020

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Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate

31 March 2020

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Estrogen Receptors as Therapeutic Targets in Breast Cancer

31 March 2020

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The development of androgen-independent prostate cancer

31 March 2020

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Connections and regulation of the human estrogen receptor

31 March 2020

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Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF

31 March 2020

1 reference

Identification of a gene (GPR30) with homology to the G-protein-coupled receptor superfamily associated with estrogen receptor expression in breast cancer

31 March 2020

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A transmembrane intracellular estrogen receptor mediates rapid cell signaling

31 March 2020

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Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells

31 March 2020

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Androgen receptor activation by G(s) signaling in prostate cancer cells

31 March 2020

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FHL2, a novel tissue-specific coactivator of the androgen receptor

31 March 2020

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A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer

31 March 2020

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COX-2: a molecular target for colorectal cancer prevention

31 March 2020

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

31 March 2020

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A ride on the ferrous wheel.

31 March 2020

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Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

31 March 2020

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Cancer genes and the pathways they control

31 March 2020

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Tumor formation by genetic mutations in the components of the Wnt signaling pathway

31 March 2020

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Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

31 March 2020

1 reference

Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer

31 March 2020

1 reference

Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer

31 March 2020

1 reference

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

31 March 2020

1 reference

β-Catenin activates the growth factor endothelin-1 in colon cancer cells

31 March 2020

1 reference

COX inhibitors and breast cancer

31 March 2020

1 reference

Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice

31 March 2020

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The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia

31 March 2020

1 reference

Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer

31 March 2020

1 reference

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

31 March 2020

1 reference

The genetics of malignant melanoma: lessons from mouse and man.

31 March 2020

1 reference

Genetics of Hair and Skin Color

31 March 2020

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Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?

31 March 2020

1 reference

Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas

31 March 2020

1 reference

GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.

31 March 2020

1 reference

Two G protein oncogenes in human endocrine tumors

31 March 2020

1 reference

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

31 March 2020

1 reference

The Hedgehog response network: sensors, switches, and routers

31 March 2020

1 reference

Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

1 reference

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

31 March 2020

1 reference

The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling

31 March 2020

1 reference

Activation of heterotrimeric G proteins by Smoothened

31 March 2020

1 reference

The Wnt connection to tumorigenesis

31 March 2020

1 reference

Wnt signaling in disease and in development

31 March 2020

1 reference

WNT and beta-catenin signalling: diseases and therapies

31 March 2020

1 reference

Activation of rat frizzled-1 promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via pathways that require Galpha(q) and Galpha(o) function

31 March 2020

1 reference

Frizzleds: new members of the superfamily of G-protein-coupled receptors

31 March 2020

1 reference

Rapid, Wnt-induced changes in GSK3beta associations that regulate beta-catenin stabilization are mediated by Galpha proteins

31 March 2020

1 reference

Dissemination and growth of cancer cells in metastatic sites

31 March 2020

1 reference

Cancer and the chemokine network

31 March 2020

1 reference

Involvement of chemokine receptors in breast cancer metastasis

31 March 2020

1 reference

The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies

31 March 2020

1 reference

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

31 March 2020

1 reference

CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

31 March 2020

1 reference

Targeting HIF-1 for cancer therapy

31 March 2020

1 reference

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

31 March 2020

1 reference

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

31 March 2020

1 reference

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

31 March 2020

1 reference

Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion

31 March 2020

1 reference

Thrombin inhibitor, argatroban, prevents tumor cell migration and bone metastasis

31 March 2020

1 reference

How matrix metalloproteinases regulate cell behavior

31 March 2020

1 reference

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

31 March 2020

1 reference

Inflammatory chemokines in cancer growth and progression

31 March 2020

1 reference

KiSS-1, a novel human malignant melanoma metastasis-suppressor gene

31 March 2020

1 reference

Metastasis suppressors alter the signal transduction of cancer cells

31 March 2020

1 reference

Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor

31 March 2020

1 reference

Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins.

31 March 2020

1 reference

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.

31 March 2020

1 reference

Role of thrombin in angiogenesis and tumor progression

31 March 2020

1 reference

Cancer CXC chemokine networks and tumour angiogenesis

31 March 2020

1 reference

Human neutrophils promote angiogenesis by a paracrine feedforward mechanism involving endothelial interleukin-8.

31 March 2020

1 reference

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

31 March 2020

1 reference

Cyclooxygenase-2: a therapeutic target in angiogenesis.

31 March 2020

1 reference

Cyclooxygenase-2-dependent expression of angiogenic CXC chemokines ENA-78/CXC Ligand (CXCL) 5 and interleukin-8/CXCL8 in human non-small cell lung cancer

31 March 2020

1 reference

31 March 2020

1 reference

PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways

31 March 2020

1 reference

Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responses

31 March 2020

1 reference

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

31 March 2020

1 reference

Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics

31 March 2020

1 reference

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

31 March 2020

1 reference

Signaling and biological actions of sphingosine 1-phosphate

31 March 2020

1 reference

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

31 March 2020

1 reference

G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches.

31 March 2020

1 reference

The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population

31 March 2020

1 reference

Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan

31 March 2020

1 reference

Genetic variation in G-protein-coupled receptors--consequences for G-protein-coupled receptors as drug targets

31 March 2020

1 reference

Radiolabeled peptide conjugates for targeting of the bombesin receptor superfamily subtypes

31 March 2020

1 reference

Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy

31 March 2020

1 reference

Viral hijacking of G-protein-coupled-receptor signalling networks.

31 March 2020

1 reference

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

31 March 2020

1 reference

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor

31 March 2020

1 reference

Sirolimus for Kaposi's sarcoma in renal-transplant recipients

31 March 2020

1 reference

Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor

31 March 2020

1 reference

Virus-encoded chemokine receptors--putative novel antiviral drug targets

31 March 2020

1 reference

Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis.

31 March 2020

1 reference

Human herpesvirus 6: molecular biology and clinical features.

31 March 2020

1 reference

Human cytomegalovirus encodes three G protein-coupled receptor homologues.

31 March 2020

1 reference

Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28.

31 March 2020

1 reference

HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks

31 March 2020

1 reference

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

31 March 2020

1 reference

Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

31 March 2020

1 reference

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

31 March 2020

1 reference

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

31 March 2020

1 reference

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

31 March 2020

1 reference

Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to beta-catenin stabilization

31 March 2020

1 reference

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

31 March 2020

1 reference

Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells

31 March 2020

1 reference

Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

31 March 2020

1 reference

Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.

31 March 2020

1 reference

Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer

31 March 2020

1 reference

Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypox

31 March 2020

1 reference

Inhibition of growth of experimental human and hamster pancreatic cancers in vivo by a targeted cytotoxic bombesin analog.

31 March 2020

1 reference

Calcium-induced activation of a mutant G-protein-coupled receptor causes in vitro transformation of NIH/3T3 cells

31 March 2020

1 reference

Malignant pituitary tumours

31 March 2020

1 reference

Renin-angiotensin system is an important factor in hormone refractory prostate cancer

31 March 2020

1 reference

Genetics of melanoma predisposition

31 March 2020

1 reference

Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells

31 March 2020

1 reference

Association between endothelin receptor B nonsynonymous variants and melanoma risk

31 March 2020

1 reference

Activating Smoothened mutations in sporadic basal-cell carcinoma

31 March 2020

1 reference

Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2069

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17251915%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 December 2019

1033550821

0 references

Fatcat ID

release_74r77isevzchhk5cnvqp6qksba

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/74r77isevzchhk5cnvqp6qksba

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference