(Q34609157)

3 August 2017

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title

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics (English)

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3 August 2017

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Howard L McLeod

1

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3 August 2017

Chokkalingam Siva

series ordinal

2

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3 August 2017

language of work or name

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1 January 2002

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3 August 2017

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3 August 2017

volume

3

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3 August 2017

issue

1

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3 August 2017

page(s)

89-98

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Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

3 August 2017

cites work

1 reference

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Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

21 January 2018

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Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

21 January 2018

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Human kidney thiopurine methyltransferase. Purification and biochemical properties.

21 January 2018

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Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

21 January 2018

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Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

21 January 2018

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Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

21 January 2018

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Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

21 January 2018

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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

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Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

21 January 2018

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Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

21 January 2018

1 reference

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Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis

21 January 2018

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Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

21 January 2018

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A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

21 January 2018

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Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.

21 January 2018

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Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese

21 January 2018

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Genotypic and phenotypic analysis of the polymorphic thiopurine S-methyltransferase gene (TPMT) in a European population.

21 January 2018

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Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

21 January 2018

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Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

21 January 2018

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Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity

21 January 2018

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Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine

21 January 2018

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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

21 January 2018

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High incidence of secondary brain tumours after radiotherapy and antimetabolites.

21 January 2018

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Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism

21 January 2018

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https://api.crossref.org/works/10.1517%2F14622416.3.1.89

Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.3.1.89

Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine

21 January 2018

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Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

21 January 2018

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Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.3.1.89

Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14622416.3.1.89

Pharmacogenomics: unlocking the human genome for better drug therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14622416.3.1.89

Thiopurine methyltransferase alleles in British and Ghanaian populations

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1517/14622416.3.1.89

1 reference

3 August 2017

1 reference