(Q34620191)

3 August 2017

1 reference

title

Structure-based screening of low-affinity compounds (English)

1 reference

3 August 2017

Robin Carr

1

1 reference

PubMed ID

11983569

3 August 2017

Harren Jhoti

series ordinal

2

1 reference

3 August 2017

1 May 2002

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3 August 2017

1 reference

3 August 2017

7

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3 August 2017

522-527

1 reference

3 August 2017

9

1 reference

Science, art and drug discovery: a personal perspective

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Is there a difference between leads and drugs? A historical perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

NMR-based screening in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

The SHAPES strategy: an NMR-based approach for lead generation in drug discovery.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Discovering novel ligands for macromolecules using X-ray crystallographic screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Automation of X-ray crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

High-throughput structural proteomics using x-rays

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

High-throughput three-dimensional protein structure determination.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

High-throughput crystallography for lead discovery in drug design.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

High-throughput proteomics: protein expression and purification in the postgenomic world.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

High-throughput protein crystallization

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Recent developments in software for the automation of crystallographic macromolecular structure determination

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Structural genomics programs at the US National Institute of General Medical Sciences

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Structural genomics in the biotechnology sector

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Global Efforts in Structural Genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

The Protein Data Bank and the challenge of structural genomics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Drug discovery: a historical perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Synchrotron crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Experiences with CCD detectors on a home X-ray source

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Automated crystal mounting and data collection for protein crystallography

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Virtual screening—an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Development and validation of a genetic algorithm for flexible docking

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Protein-based virtual screening of chemical databases. 1. Evaluation of different docking/scoring combinations.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

The properties of known drugs. 1. Molecular frameworks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Properties of known drugs. 2. Side chains

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

1-Aminoisoquinoline as benzamidine isoster in the design and synthesis of orally active thrombin inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

Design of adenosine kinase inhibitors from the NMR-based screening of fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902245-6

7 January 2021

10.1016/S1359-6446(02)02245-6

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11983569